Patents by Inventor Gary K. Darland

Gary K. Darland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8557306
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: October 15, 2013
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Publication number: 20120270837
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Application
    Filed: April 30, 2012
    Publication date: October 25, 2012
    Applicant: METAPROTEOMICS, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 8257754
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: September 4, 2012
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence M. Howell
  • Publication number: 20120183634
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Application
    Filed: March 26, 2012
    Publication date: July 19, 2012
    Applicant: METAPROTEOMICS, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Publication number: 20120177756
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Application
    Filed: March 26, 2012
    Publication date: July 12, 2012
    Applicant: METAPROTEOMICS, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 8168234
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: May 1, 2012
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 8142819
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: March 27, 2012
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7919125
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandin selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: April 5, 2011
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence M. Howell
  • Patent number: 7901713
    Abstract: A natural formulation of compounds isolated or derived from hops which inhibit the activity of cyclooxygenase-2 (COX-2) and/or 5-lipoxygenase (5-LOX) is disclosed. The hops formulations may be administered to a mammal to treat or inhibit a pathological condition associated with the activity of COX-2 and/or 5-LOX in such a mammal.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: March 8, 2011
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, Gary K. Darland, Mark Fuller, John G. Babish, Jeffrey S. Bland
  • Publication number: 20110021638
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandin selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Application
    Filed: April 7, 2010
    Publication date: January 27, 2011
    Applicant: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7820206
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: October 26, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7815944
    Abstract: The invention provides hops (Humulis lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: October 19, 2010
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
  • Patent number: 7807203
    Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: October 5, 2010
    Assignee: Metaprotemics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
  • Patent number: 7794757
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: September 14, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7790205
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: September 7, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Publication number: 20100222262
    Abstract: Compositions and methods for reducing cardiovascular risk utilizing substituted 1,3-cyclopentadione compounds are described.
    Type: Application
    Filed: April 2, 2009
    Publication date: September 2, 2010
    Applicant: METAPROTEOMICS, LLC
    Inventors: Veera Konda, Anu Desai, Matthew L. Tripp, Gary K. Darland, Joseph Lamb, Jeffrey S. Bland, Dennis A. Emma
  • Publication number: 20100184857
    Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Application
    Filed: September 22, 2009
    Publication date: July 22, 2010
    Applicant: METAPROTEOMICS, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
  • Patent number: 7722903
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: May 25, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7666449
    Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: February 23, 2010
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
  • Publication number: 20090118373
    Abstract: A natural formulation of compounds isolated or derived from hops which inhibit the activity of cyclooxygenase-2 (COX-2) and/or 5-lipoxygenase (5-LOX) is disclosed. The hops formulations may be administered to a mammal to treat or inhibit a pathological condition associated with the activity of COX-2 and/or 5-LOX in such a mammal.
    Type: Application
    Filed: June 10, 2004
    Publication date: May 7, 2009
    Inventors: Matthew L. Tripp, Gary K. Darland, Mark Fuller, John G. Babish, Jeffrey S. Bland