Abstract: Immunoassay for isothiazolones based on monoclonal antibodies that react with isothiazolones, particularly, 5-chloro-2-methyl-3-isothiazolone, hybridomas that produce such antibodies, especially ATCC HB 11435, a method of preparing an immunogenic conjugate of isothiazolones and a macromolecule carrier, a method of producing monoclonal antibodies reactive with isothiazolones, and compositions comprising monoclonal or polyclonal antibodies reactive with isothiazolones.

Abstract: Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-n-octyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.

Abstract: Disclosed herein are compositions comprisinga) at least one 3-isothiazolone of the formula (I) ##STR1## wherein Y is an unsubstituted or substituted (C.sub.1 -C.sub.18) alkyl, an unsubstituted or substituted (C.sub.3 -C.sub.12) cycloalkyl, an unsubstituted or halogen-substituted (C.sub.2 -C.sub.8) alkenyl or alkynyl, an unsubstituted or substituted (C.sub.7 -C.sub.10) aralkyl, or an unsubstituted or substituted aryl; andR and R.sup.1 is each independently H, halogen or (C.sub.1 -C.sub.4) alkyl; andb) a carbonyl compound selected from the group consisting of (C.sub.2 -C.sub.6) aldehydes, (C.sub.7 -C.sub.10) aromatic aldehydes or acids, (C.sub.2 -C.sub.4) dialdehydes, (C.sub.1 -C.sub.12) acids, (C.sub.2 -C.sub.8) diacids, triacids or tetracids, (C.sub.3 -C.sub.10) .alpha.,.beta. unsaturated carbonyls, (C.sub.1 -C.sub.6) haloamides of the formula ##STR2## where R.sub.1 =phenyl or (C.sub.1 -C.sub.4)alkyl, substituted phenyl,R.sub.2 =(C.sub.1 -C.sub.7)alkyl, (C.sub.1 -C.sub.7)alkoxylalkyl, or (C.sub.1 -C.sub.

Abstract: Disclosed are the use of hexamethylenetetramine as a stabilizer for 3-isothiazolones under basic conditions, i.e. above pH 7.0, and compositions comprising HMT and 3-isothiazolones.

Abstract: Synergistic antialgal compositions comprising substituted fluoroalkyl diphenylethers and a material selected from the group consisting of sodium hypochlorite, halodialkylhydantoin, n-alkyl dimethyl benzylammonium chloride, 2,2-dibromo-3-nitrilopropionamide, 2-bromo-2-nitro-1,3-propanediol, poly[oxyethylene(dimethylimino)ethylene(dimethylimino)ethylene dichloride], 3-iodo-2-propynylbutylcarbamate, sodium N-methyldithiocarbamate, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, N-(phosphonomethyl)glycine and salts thereof, zinc bis(dimethyldithiocarbamate), p-tolydiiodomethylsulfone and fatty acid salt in ratios to each other which exhibit synergism are disclosed. Particularly effective combinations are based on oxyfluorfen as the diphenylether for use in protecting aqueous systems, such as latices and cooling water systems, from algal growth.

Abstract: Specific triazoles discovered to be useful as industrial fungicides are:1. .alpha.-n-butyl-.alpha.-phenyl-1H-1,2,4-triazole-1-propanenitrile2. .alpha.,.alpha.-diphenyl-1H-1,2,4-triazole-1-propanenitrile3. .alpha.-benzyl-.alpha.-phenyl-1H-1,2,4-triazole-1-propanenitrile4. .alpha.-n-butyl-.alpha.-2-methoxyphenyl-1H-1,2,4-triazole-1-propanenitrile5. .alpha.-n-butyl-.alpha.-4-fluorophenyl-1H-1,2,4-triazole-1-propanenitrile6. .alpha.-phenyl-.alpha.-(2-phenylethyl)-1H-1,2,4-triazole-1-propanenitrile7. .alpha.-(4-fluorophenyl)-.alpha.-n-propyl-1H-1,2,4-triazole-1-propanenitri le8. .alpha.-[2-(4-chlorophenyl)ethyl]-.alpha.-phenyl-1H-1,2,4-triazole-1- propanenitrile9. .alpha.-n-butyl-.alpha.

Abstract: A composition comprising:(a) A 3-isothiazolone compound(b) a stabilizing amount of a metal salt, said metal salts selected from the group where the cation is copper, zinc, manganese, ferrous or ferric, and the anion is selected from the group consisting of an organic carboxylic acid of at least of six carbon atoms, EDTA, 8-hydroxyquinolinate, gluconate, o-phenanthroline, quinolinate, N,N-bis(2-hydroxy-5-sulfobenzyl) glycine, lignosulfonate polymers, and polyacrylates; and(c) a locus to be protected against the growth of algae, bacteria, or fungi, selected from the group consisting of:(i) a metal working fluid (MWF) comprising at least one component selected from the group consisting of an alkanolamine, a petroleum sulfonate emulsifier, a boric acid ester or boric acid amide, a corrosion inhibitor, and a fatty acid;(ii) cooling tower water comprising corrosion inhibitors or scale inhibitors,(iii) laundry dish water;(iv) a cosmetic formulation;(v) a fuel system;(vi) an emulsion;(vii) a solid protective or decor

Abstract: Synergistic antialgal compositions comprising substituted fluoroalkyl diphenylethers and a material selected from the group consisting of sodium hypochlorite, halodialkylhydantoin, n-alkyl dimethyl benzylammonium chloride, 2,2-dibromo-3-nitrilopropionamide, 2-bromo-2-nitro-1,3-propanediol, poly[oxyethylene(dimethylimino)ethylene(dimethylimino)ethylene dichloride], 3-iodo-2-propynylbutylcarbamate, sodium N-methyldithiocarbamate, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, N-(phosphonomethyl)glycine and salts thereof, zinc bis(dimethyldithiocarbamate), p-tolyldiiodomethylsulfone and fatty acid salt in ratios to each other which exhibit synergism are disclosed. Particularly effective combinations are based on oxyfluorfen as the diphenylether for use in protecting aqueous systems, such as latices and cooling water systems, from algal growth.

Abstract: Composition comprising (A) 3-isothiazolone biocide compound and (B) an amount of a second compound selected from the group consisting of antimony salts to stabilize said 3-isothiazolone and method of stabilizing the 3-isothiazolones comprising combining with the antimony salts are disclosed.

Abstract: A method of stabilizing 3-isothiazolones against chemical degradation in antagonistic environments by the use of certain activated halogen compounds is disclosed. Compositions including 3-isothiazolones and alkyl halohydantoins, halo-substituted triazinetriones, N-halosuccinimides, p-toluenesulfonyl halides, haloacetic acids and alkyl sulfamoyl halides are found to be particularly stable in metal working fluids and latex paints.

Abstract: Composition comprising (A) 3-isothiazolone antimicrobial compound and (B) an amount of a second hydrazide compound to stabilize said 3-isothiazolone, and method of stabilizing 3-isothiazolone antimicrobial compound, and method of use to inhibit growth of bacteria, fungi, algae, and yeast at a locus are disclosed.

Abstract: A method for determining the concentration of isothiazolones in an aqueous system comprising:(a) mixing a known volume of solution to be analyzed with a volume containing a known quantity of aromatic thiol salts which form colored solutions for a specified period of time;(b) determining color of the resultant solution; and(c) comparing the color to a standard of known concentration.This invention is especially applicable to cooling towers and in the metal working industry and for fuel.

Abstract: Bismuth salt stabilizers are used to stabilize various isothiazolones which are normally neat or in solution. These compositions exhibit bactericidal, fungicidal and algaecidal properties.

Abstract: Phenoxyalkanols are used to stabilize isothiazolone concentrates.