Patents by Inventor Gary Lowell Engel

Gary Lowell Engel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain 1-(D-cycloproplyglycinyl)-4-piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor Xa
    Patent number: 7166606
    Abstract: The compounds of formula (I) in which R represents a hydrogen atom or a fluorine atom, or a pharmaceutically acceptable salt thereof are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: January 23, 2007
    Assignee: Eli Lilly and Company
    Inventors: Michael Robert Wiley, Gary Lowell Engel
  • Lactam compound
    Publication number: 20040248878
    Abstract: The present invention provides crystalline (N)—((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one dihydrate, compositions thereof, and methods for using the same, processes for making the same, and processes for making intermediates thereof.
    Type: Application
    Filed: April 28, 2003
    Publication date: December 9, 2004
    Inventors: Thomas Mitchell Koenig, James Edmund Audia, David Mitchell, Stacey Leigh McDaniel, Lynne Ann Buccilli, Gary Lowell Engel, James Abraham Aikins
  • Pharmaceutical compound
    Publication number: 20040162295
    Abstract: 1-(Indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine Difumarate forms a stable crystalline salt and is an inhibitor of the serine protease, Factor Xa, useful in the treatment of cardiovascular disorders.
    Type: Application
    Filed: November 17, 2003
    Publication date: August 19, 2004
    Inventors: Gary Lowell Engel, Benjamin Alan Diseroad
  • Protein kinase C inhibitor
    Patent number: 6117861
    Abstract: This invention provides novel bis-indolylmaleimide macrocycle derivatives of the formula: ##STR1## and solvates thereof. The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: September 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Gary Lowell Engel, Nagy Alphonse Farid, Margaret Mary Faul, Michael Robert Jirousek, Lori Ann Richardson, Leonard Larry Winneroski, Jr.
  • Protein kinase C inhibitor
    Patent number: 6015807
    Abstract: This invention provides novel bis-indolylmaleimide macrocycle derivatives of the formula: and solvates thereof. The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: January 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Gary Lowell Engel, Nagy Alphonse Farid, Margaret Mary Faul, Michael Robert Jirousek, Lori Ann Richardson, Leonard Larry Winneroski, Jr.
  • Protein kinase C inhibitor
    Patent number: 5710145
    Abstract: This invention provides novel bis-indolylmaleimide macrocycle derivatives of the formula: ##STR1## and solvates thereof. The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: January 20, 1998
    Assignee: Eli Lilly and Company
    Inventors: Gary Lowell Engel, Nagy Alphonse Farid, Margaret Mary Faul, Michael Robert Jirousek, Lori Ann Richardson, Leonard Larry Winneroski, Jr.