Patents by Inventor Gary M. Karp

Gary M. Karp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE
    Publication number: 20170204073
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 20, 2017
    Applicant: PTC Therapeutics, Inc.
    Inventors: Neil Almstead, Guangming Chen, Gary M. Karp, Ellen Welch, Richard Wilde, Jeffrey A. Campbell
  • 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
    Patent number: 9611230
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: April 4, 2017
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil G. Almstead, Guangming Chen, Gary M. Karp, Ellen Welch, Richard Wilde, Jeffrey A. Campbell
  • Compounds for Nonsense Suppression, and Methods for Their Use
    Publication number: 20160229818
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Applicant: PTC Therapeutics, Inc.
    Inventors: Neil Almstead, Gary M. Karp, Richard Wilde, Ellen Welch, Hongyu Ren
  • METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH
    Publication number: 20160199357
    Abstract: The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
    Type: Application
    Filed: February 16, 2016
    Publication date: July 14, 2016
    Inventors: Neil ALMSTEAD, Guangming CHEN, Samit HIRAWAT, Peter Seongwoo HWANG, Gary M. KARP, Paul KENNEDY, Langdon MILLER, Young-Choon MOON, Hongyu REN, James J. TAKASUGI, Ellen M. WELCH, Richard G. WILDE
  • Compounds for nonsense suppression, and methods for their use
    Patent number: 9315467
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: April 19, 2016
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil Almstead, Gary M. Karp, Richard Wilde, Ellen Welch, Hongyu Ren
  • Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
    Patent number: 9289398
    Abstract: The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: March 22, 2016
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil Almstead, Guangming Chen, Samit Hirawat, Peter Seongwoo Hwang, Gary M. Karp, Langdon Miller, Young-Choon Moon, Hongyu Ren, James J. Takasugi, Ellen M. Welch, Richard G. Wilde, Paul Kennedy
  • PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES
    Publication number: 20150274674
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: June 8, 2015
    Publication date: October 1, 2015
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Neil Almstead, Gary M. Karp, Richard Wilde, Ellen Welch, Jeffrey A. Campbell, Hongyu Ren, Guangming Chen
  • Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases
    Patent number: 9051342
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: June 9, 2015
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil Almstead, Gary M. Karp, Richard Wilde, Ellen Welch, Jeffrey A. Campbell, Hongyu Ren, Guangming Chen
  • METHODS FOR TREATING HEPATITIS C
    Publication number: 20110268698
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.
    Type: Application
    Filed: June 13, 2011
    Publication date: November 3, 2011
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Gary M. KARP, Peter Seongwoo HWANG, James J. TAKASUGI, Hongyu REN, Richard Gerald WILDE, Anthony A. TURPOFF, Alexander AREFOLOV, Guangming CHEN, Jeffrey Allen CAMPBELL, Chunshi Li, Steven Paget, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Methods for treating hepatitis C
    Patent number: 7973069
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: July 5, 2011
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary M. Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony A. Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey Allen Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Jin Zhu, Xiaoyan Zhang
  • METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
    Publication number: 20110046136
    Abstract: The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
    Type: Application
    Filed: March 29, 2007
    Publication date: February 24, 2011
    Applicant: THERAPEUTICS, INC.
    Inventors: Neil G. Almstead, Guangming Chen, Hirawat Samit, Peter Seongwoo Hwang, Gary M. Karp, Langdon Miller, Young-Choon Moon, Hongyu Ren, James J. Takasugi, Ellen M. Welch, Richard G. Wilde, Paul Kennedy
  • METHODS FOR TREATING HEPATITIS C
    Publication number: 20100292187
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Application
    Filed: June 14, 2010
    Publication date: November 18, 2010
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Gary M. Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony A. Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey A. Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Methods for treating hepatitis C
    Patent number: 7781478
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: August 24, 2010
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary M. Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony A. Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey Allen Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Jin Zhu, Xiaoyan Zhang
  • Compounds for Nonsense Suppression, and Methods for Their Use
    Publication number: 20090253699
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: October 13, 2005
    Publication date: October 8, 2009
    Applicant: PCT Therapeutics, Inc.
    Inventors: Neil G. Almstead, Guangming Chen, Gary M. Karp, Ellen Welch, Richard Wilde, Jeffrey A. Campbell
  • Pyrazole or Triazole Compounds and Their Use for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases
    Publication number: 20080280869
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: October 13, 2005
    Publication date: November 13, 2008
    Inventors: Neil Almstead, Gary M. Karp, Richard Wilde, Ellen Welch, Jeffrey A. Campbell, Hongyu Ren, Guangming Chen
  • Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases
    Publication number: 20080269191
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: October 13, 2005
    Publication date: October 30, 2008
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Richard Wilde, Ellen Welch, Gary M. Karp
  • Compounds for Nonsense Suppression, and Methods for Their Use
    Publication number: 20080119473
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: October 13, 2005
    Publication date: May 22, 2008
    Inventors: Neil Almstead, Gary M. Karp, Richard Wilde, Ellen Welch, Hongyu Ren
  • 1 - (3-heterocyclylphenyl) isothiourea, -isourea, -guanidine and -amidine herbicidal agents
    Publication number: 20020137929
    Abstract: There are provided 1-(3-heterocyclyphenyl)isothiourea, -isourea, -guanidine and -amidine compounds of formula I 1
    Type: Application
    Filed: August 16, 2001
    Publication date: September 26, 2002
    Applicant: Intellectual Property Department, BASF Aktiengesellschaft
    Inventor: Gary M. Karp
  • 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents
    Patent number: 5616706
    Abstract: There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 1, 1997
    Assignee: American Cyanamid Company
    Inventors: Alvin D. Crews, Jr., Philip M. Harrington, Gary M. Karp, Mark C. Manfredi, Michael A. Guaciaro
  • 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiortione herbicidal agents
    Patent number: 5612481
    Abstract: There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 18, 1997
    Assignee: American Cyanamid Company
    Inventors: Alvin D. Crews, Jr., Philip M. Harrington, Gary M. Karp, Mark C. Manfredi, Michael A. Guaciaro