Patents by Inventor Gary M. Nishioka

Gary M. Nishioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5449754
    Abstract: Ink-jet printing technology is applied to the creation of multi unit chemical compound libraries. Ink-jet type nozzles are used to inject multiple droplets onto the surface an appropriate support, such droplets consisting of solutions containing units of the chemical compound that will attach to the support surface. Droplets are then injected, by such nozzles, onto the support attached unit droplets that contain units that will attach to such support attached units. The second step is repeated to create multiple varying unit chemical compounds. Ink-jet printing technology allows the deposition of small droplets that do not overlap or splatter. The system is particularly useful in the creation of libraries of multiple peptide compounds where the units are amino acids.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: September 12, 1995
    Assignee: H & N Instruments, Inc.
    Inventor: Gary M. Nishioka
  • Patent number: 5318679
    Abstract: The present invention is an improved method of making sequenced chemical chain compounds through the application of laser copy technology to UV light directed spatially addressed parallel chemical synthesis and is particularly useful in the production of numerous proteins of varying amino acid sequences on a restricted solid support. Chemical groups, such as amines, are attached to the surface of a solid sup- port, such as flat glass, and subjected to chemical reaction disposed to link chemical units to the attached groups that are protected from further reaction by photolabile groups. Such solid support and photolabile protected units are then selectively deprotected by irradiation with a UV laser beam. The support and attached units are then subjected to chemical reaction to link chemical units to the selectively deprotected units. By repeated such treatment it is possible to produce unlimited combinations of chain chemical units in less time and at greater efficiency than has previously been possible.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: June 7, 1994
    Assignee: H & N Instruments, Inc.
    Inventor: Gary M. Nishioka
  • Patent number: 4749653
    Abstract: Enzymes are immobilized on non-porous glass fibers by coating glass fibers with a solution containing an enzyme and a soluble polymer and contacting the coated fibers with a controlled amount of cross-linking agent to obtain an immobilized enzyme having high activity and long endurance, and which provides a high percentage of conversion. The enzyme may be an amylase, the polymer a plyalkyleneimine and the cross-linking agent glutaraldehyde. Continuous immobilization can be carried out by moving continuous fibers to applicator stations for applying a solution of enzyme and polymer and a solution of cross-linking agent.
    Type: Grant
    Filed: October 21, 1985
    Date of Patent: June 7, 1988
    Assignee: Owens-Corning Fiberglas Corporation
    Inventors: David M. Lee, Gary M. Nishioka, Wayne E. Swann, Carol A. Nolf
  • Patent number: 4732879
    Abstract: A method for applying porous, preferably catalytically active metal oxide coatings to relatively non-porous substrates in a fibrous form, and the catalyst materials thereby obtained. A solution is formed of one or more hydrolyzable precursors of metal oxides, in an anhydrous, organic solvent. The substrate to be coated, having active surface hydroxyl groups and preferably being glass or ceramic, is dipped into the solution and thereafter removed, drained and dried in an atmosphere containing water vapor so as to form a uniform, and at least partially hydrolyzed metal hydroxide/alkoxide coating on the substrate. The thus coated substrate is cured by heating in one or more stages at temperatures in the range of between about 250.degree. and 500.degree. C. to form an adherent, highly porous coating of the corresponding metal oxide.
    Type: Grant
    Filed: November 8, 1985
    Date of Patent: March 22, 1988
    Assignee: Owens-Corning Fiberglas Corporation
    Inventors: Marie R. Kalinowski, Gary M. Nishioka
  • Patent number: 4455330
    Abstract: The insulation resistance of glass fibers is improved by contacting the glass fibers with monofunctional silanes such as phenyldimethylethoxysilane
    Type: Grant
    Filed: August 4, 1982
    Date of Patent: June 19, 1984
    Assignee: Owens-Corning Fiberglas Corporation
    Inventors: Gary M. Nishioka, Sheldon P. Wesson