Patents by Inventor Gary Matyas

Gary Matyas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • recombinanr xiexumapoeozoite protein compositions and method for vaccine delivery
    Patent number: 11583578
    Abstract: The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 21, 2023
    Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Government Of The United States, As Represented By The Secretary Of The Army
    Inventors: Sheetij Dutta, Zoltan Beck, Carl Alving, Gary Matyas
  • Compositions and Methods for Vaccine Delivery
    Publication number: 20220160855
    Abstract: The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 26, 2022
    Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Sheetij Dutta, Zoltan Beck, Carl Alving, Gary Matyas
  • Detection of human antibodies to squalene in serum
    Publication number: 20060160160
    Abstract: The invention is a method and assay for detecting human squalene antibodies in sera or plasma using a blocking agent of ?0.5% casein in a phosphate buffered saline (PBS) solution.
    Type: Application
    Filed: January 7, 2005
    Publication date: July 20, 2006
    Inventors: Carl Alving, Gary Matyas, Nabila Wassef, Mangala Rao