Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): (structurally represented) or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Abstract: A system for crop production management includes instructions executing on a computing device for collecting and displaying field specific agricultural data and business data sufficient for a crop producer to make determinations regarding agricultural inputs including seed, fertilizer, and chemicals; an ordering system associated with a back-end computing system for providing pricing for the agricultural inputs on a per unit basis and on a field-by-field basis; and an inventory system associated with the back-end computing system and operatively connected to the ordering system for updating inventory for the agricultural inputs associated with an agricultural service business providing the agricultural inputs to the crop producer; wherein the back-end computing system is in operative communication with the computing device.

Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Abstract: A system and method are provided and include an equipment controller for operating a piece of kitchen equipment. The equipment controller has a memory storing an initial menu of food items each having associated operating parameters for operating the kitchen equipment when preparing the associated food item. The system also includes a supervisory controller in communication with the equipment controller and in communication with a remote monitor that receives an updated menu for the kitchen equipment from a remote terminal. The updated menu includes at least one of a food item modification and an operating parameter modification. The supervisory controller receives the updated menu from the remote monitor and communicates the updated menu to the equipment controller for installation by the equipment controller.

Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Abstract: A personal storm shelter has a cover, pillar support, and a tensioning device. When a locking lever is moved in a downward motion or into a closed position, it puts the tensioning device in tension and locks said cover portion to the ground by way of an anchoring support. Cover portion thereby protects any objects inside cover portion area from outside influences.

Abstract: Superabsorbent polymer products for use in agricultural applications, and methods of making the same, are provided. The superabsorbent polymer is used in a seed coating along with an active ingredient, and optionally a singulating substance, to improve seed germination and/or blooming; improve germination under dry conditions; decrease irrigation requirements; increase propagation, crop growth, and crop production; and improve the efficacy of the active ingredient.

Abstract: A system, apparatus, and method for determining when an amount of ice formed on an evaporator or evaporator grid has reached a predetermined size are illustrated. An acoustic transmitter an acoustic transmitter positioned proximate to the evaporator channels acoustic signals emanating from the evaporator or evaporator grid to an acoustic sensor, which generates an electronic signal indicative of the acoustic signal. A receiver module coupled to the acoustic sensor is configured to receive the electronic signal and determine that ice formed on the evaporator has reached a predetermined size based on the electronic signal.

Abstract: The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.