Patents by Inventor Gary P. Durack
Gary P. Durack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9494501Abstract: The present disclosure relates to microfluidic devices adapted for post-centrifugation use with selective sample extraction, and methods for their use. Certain embodiments make use of a dye-selective sample extraction. Other embodiments make use of a geographically-selective sample extraction. Other embodiments are also disclosed.Type: GrantFiled: April 16, 2014Date of Patent: November 15, 2016Assignees: Sony Corporation, Sony Corporation of AmericaInventor: Gary P. Durack
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Patent number: 9470617Abstract: A high speed fluid switch is used to separate desired particles from a source stream containing particles, such as cells. A droplet generator creates and regulates a stream of droplets, which intersects with a source stream containing the particles to be sorted. The stream of droplets can be regulated such that portions of the source stream containing desired particles are deflected into a collection vessel, or such that portions of the source stream containing desired particles are permitted to pass uninterrupted. The high speed fluid switch may be implemented on a microfluidic chip.Type: GrantFiled: April 7, 2011Date of Patent: October 18, 2016Assignees: Sony Corporation, Sony Corporation of AmericaInventor: Gary P. Durack
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Patent number: 9176055Abstract: The various embodiments disclosed herein utilize multiple lasers that have different wavelengths and a single detection path. The lasers are mounted orthogonal to one another so that one laser will provide a forward angle light scatter (FALS) signal in the detection path, and one laser will provide a side scatter signal in the detection path (i.e., the single detection optics are approximately in-line with the FALS laser and approximately orthogonal to the side scatter laser). The single detector path spectrally separates the forward and side scatter signals prior to applying them to their respective detectors for measurement.Type: GrantFiled: September 20, 2012Date of Patent: November 3, 2015Assignees: Sony Corporation, Sony Corporation of AmericaInventors: Michael D. Zordan, Gary P. Durack, Shinji Yamada, Bharath K. Narahari, Elizabeth C. Eaton, Jeffrey D. Wallace, Larry W. Arnold, Kevin A. Keilbach
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Patent number: 9034261Abstract: A system and method are disclosed in which particles sorted by a flow cytometer may be deposited directly into a deposition layer formed on the surface of an optical disc, and information regarding measurements made of the particle, as well as the storage location of the particle, can be written to the recording layer of the optical disc.Type: GrantFiled: September 12, 2012Date of Patent: May 19, 2015Assignees: Sony Corporation, Sony Corporation of AmericaInventors: Masanobu Yamamoto, Michael D. Zordan, Gary P. Durack, Larry W. Arnold
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Patent number: 8891084Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices allow light collection from multiple directions. In certain other embodiments, the microfluidic devices use spatial intensity modulation. In certain other embodiments, the microfluidic devices have magnetic field separators. In certain other embodiments, the microfluidic devices have the ability to stack. In certain other embodiments, the microfluidic devices have 3-D hydrodynamic focusing to align sperm cells. In certain other embodiments, the microfluidic devices have acoustic energy couplers. In certain other embodiments, the microfluidic devices have phase variation producing lenses. In certain other embodiments, the microfluidic devices have transmissive and reflective lenses. In certain other embodiments, the microfluidic devices have integrally-formed optics.Type: GrantFiled: July 6, 2010Date of Patent: November 18, 2014Assignees: Sony Corporation, Sony Corporation of AmericaInventor: Gary P. Durack
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Publication number: 20140227149Abstract: The present disclosure relates to microfluidic devices adapted for post-centrifugation use with selective sample extraction, and methods for their use. Certain embodiments make use of a dye-selective sample extraction. Other embodiments make use of a geographically-selective sample extraction. Other embodiments are also disclosed.Type: ApplicationFiled: April 16, 2014Publication date: August 14, 2014Applicants: Sony Corporation, Sony Corporation of AmericaInventor: Gary P. Durack
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Patent number: 8778279Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard sterilization capabilities. In other embodiments, microfluidic devices have integral collection bags and methods for keeping the microfluidic channels clean.Type: GrantFiled: July 6, 2010Date of Patent: July 15, 2014Assignees: Sony Corporation, Sony Corporation of AmericaInventor: Gary P. Durack
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Patent number: 8735088Abstract: The present disclosure relates to microfluidic devices adapted for post-centrifugation use with selective sample extraction, and methods for their use. Certain embodiments make use of a dye-selective sample extraction. Other embodiments make use of a geographically-selective sample extraction. Other embodiments are also disclosed.Type: GrantFiled: July 6, 2010Date of Patent: May 27, 2014Assignees: Sony Corporation, Sony Corporation of AmericaInventor: Gary P. Durack
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Publication number: 20140072997Abstract: A system and method are disclosed in which particles sorted by a flow cytometer may be deposited directly into a deposition layer formed on the surface of an optical disc, and information regarding measurements made of the particle, as well as the storage location of the particle, can be written to the recording layer of the optical disc.Type: ApplicationFiled: September 12, 2012Publication date: March 13, 2014Applicants: Sony Corporation of America, Sony CorporationInventors: Masanobu Yamamoto, Michael D. Zordan, Gary P. Durack, Larry W. Arnold
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Patent number: 8569069Abstract: A sorting methodology in which bulk analysis of samples that have a low probability of containing a rare particle is performed first. Only those samples in which the bulk analysis has detected one or more rare particles are subjected to a flow cytometry process to isolate the rare particle(s). In one embodiment, a microwell plate provides for high throughput sorting in an enclosed environment. The microwell plate includes a plurality of wells and a microfluidic layer adapted for flow cytometry wherein particles from a given well are interrogated and sorted into other wells. The microfluidic layer advantageously includes fluid switches to permit bi-directional flow cytometry.Type: GrantFiled: April 19, 2011Date of Patent: October 29, 2013Assignee: Sony CorporationInventor: Gary P. Durack
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Publication number: 20130169953Abstract: The various embodiments disclosed herein utilize multiple lasers that have different wavelengths and a single detection path. The lasers are mounted orthogonal to one another so that one laser will provide a forward angle light scatter (FALS) signal in the detection path, and one laser will provide a side scatter signal in the detection path (i.e., the single detection optics are approximately in-line with the FALS laser and approximately orthogonal to the side scatter laser). The single detector path spectrally separates the forward and side scatter signals prior to applying them to their respective detectors for measurement.Type: ApplicationFiled: September 20, 2012Publication date: July 4, 2013Applicants: Sony Corporation of America, Sony CorporationInventors: Michael D. Zordan, Gary P. Durack, Shinji Yamada, Bharath K. Narahari, Elizabeth C. Eaton, Jeffrey D. Wallace, Larry W. Arnold, Kevin A. Keilbach
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Publication number: 20120094324Abstract: A sorting methodology in which bulk analysis of samples that have a low probability of containing a rare particle is performed first. Only those samples in which the bulk analysis has detected one or more rare particles are subjected to a flow cytometry process to isolate the rare particle(s). In one embodiment, a microwell plate provides for high throughput sorting in an enclosed environment. The microwell plate comprises a plurality of wells and a microfluidic layer adapted for flow cytometry wherein particles from a given well are interrogated and sorted into other wells. The microfluidic layer advantageously includes fluid switches to permit bi-directional flow cytometry.Type: ApplicationFiled: April 19, 2011Publication date: April 19, 2012Inventor: Gary P. Durack
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Publication number: 20120081709Abstract: A high speed fluid switch is used to separate desired particles from a source stream containing particles, such as cells. A droplet generator creates and regulates a stream of droplets, which intersects with a source stream containing the particles to be sorted. The stream of droplets can be regulated such that portions of the source stream containing desired particles are deflected into a collection vessel, or such that portions of the source stream containing desired particles are permitted to pass uninterrupted. The high speed fluid switch may be implemented on a microfluidic chip.Type: ApplicationFiled: April 7, 2011Publication date: April 5, 2012Inventor: Gary P. Durack
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Publication number: 20110008817Abstract: The present disclosure relates to microfluidic devices incorporating a gain medium, such as a laser gain medium, and methods for their use. Certain embodiments make use of mirrors integrated into the microfluidic device substrate. Other embodiments are also disclosed.Type: ApplicationFiled: July 6, 2010Publication date: January 13, 2011Inventor: Gary P. Durack
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Publication number: 20110008767Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices allow light collection from multiple directions. In certain other embodiments, the microfluidic devices use spatial intensity modulation. In certain other embodiments, the microfluidic devices have magnetic field separators. In certain other embodiments, the microfluidic devices have the ability to stack. In certain other embodiments, the microfluidic devices have 3-D hydrodynamic focusing to align sperm cells. In certain other embodiments, the microfluidic devices have acoustic energy couplers. In certain other embodiments, the microfluidic devices have phase variation producing lenses. In certain other embodiments, the microfluidic devices have transmissive and reflective lenses. In certain other embodiments, the microfluidic devices have integrally-formed optics.Type: ApplicationFiled: July 6, 2010Publication date: January 13, 2011Inventor: Gary P. Durack
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Publication number: 20110008818Abstract: The present disclosure relates to microfluidic devices adapted for post-centrifugation use with selective sample extraction, and methods for their use. Certain embodiments make use of a dye-selective sample extraction. Other embodiments make use of a geographically-selective sample extraction. Other embodiments are also disclosed.Type: ApplicationFiled: July 6, 2010Publication date: January 13, 2011Inventor: Gary P. Durack
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Publication number: 20110001963Abstract: A system and method for the measurement of multiple emissions in multiple flow channels in a flow cytometry system is disclosed where each excitation source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all sources in all flow channels, and the emissions are segregated using Fourier Transform techniques. The system and method are well-suited to microfluidic applications.Type: ApplicationFiled: June 30, 2010Publication date: January 6, 2011Inventor: Gary P. Durack
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Publication number: 20110003325Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard sterilization capabilities. In other embodiments, microfluidic devices have integral collection bags and methods for keeping the microfluidic channels clean.Type: ApplicationFiled: July 6, 2010Publication date: January 6, 2011Inventor: Gary P. Durack
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Publication number: 20110003324Abstract: The present disclosure is generally directed to systems for the storage and preservation of an original tissue or cell sample onboard a microfluidic device, such as a cytometry chip. In some embodiments, the sample may be disassociated while onboard the microfluidic device.Type: ApplicationFiled: July 6, 2010Publication date: January 6, 2011Inventor: Gary P. Durack
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Publication number: 20110003330Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard data storage capabilities. In certain other embodiments, the microfluidic devices have onboard anticoagulants. In certain other embodiments, the microfluidic devices have onboard test and control channels. In certain other embodiments, the microfluidic devices have integrated collection media. In certain other embodiments, the microfluidic devices have multiple onboard test channels. In certain other embodiments, the microfluidic devices have localized temperature control. In certain other embodiments, the microfluidic devices have anatomy simulating regions. In certain other embodiments, the microfluidic devices have complete assay capabilities. In certain other embodiments, the microfluidic devices have dissociable sections.Type: ApplicationFiled: July 6, 2010Publication date: January 6, 2011Inventor: Gary P. Durack