Patents by Inventor Gary P. Wiesehahn

Gary P. Wiesehahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of blood component decontamination by glucose addition
    Patent number: 5176921
    Abstract: Biological compositions are freed of functional polynucletides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their original physiological activities and any polynucleotide present is rendered inactive. More specifically blood components are decontaminated of viruses by the addition of psoralen and irradiation and thereafter adding glucose.
    Type: Grant
    Filed: May 11, 1989
    Date of Patent: January 5, 1993
    Assignees: Diamond Scientific Co., University of California
    Inventors: Gary P. Wiesehahn, Laurence Corash
  • Preparation of inactivated viral vaccines
    Patent number: 5106619
    Abstract: Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: April 21, 1992
    Assignee: Diamond Scientific Co.
    Inventors: Gary P. Wiesehahn, Richard P. Creagan, David R. Stevens, Richard Giles
  • FVR vaccine
    Patent number: 4791062
    Abstract: Novel vaccines for feline viral rhinotracheitis are prepared by psoralen inactivation of live Feline Herpesvirus I by exposure to ultraviolet radiation in the presence of an inactivating furocoumarin. The resulting inactivated viruses are suitable as the immunogenic substances in vaccines, which vaccines are useful for inoculation of hosts susceptible to feline virus rhinotracheitis.
    Type: Grant
    Filed: July 6, 1987
    Date of Patent: December 13, 1988
    Assignee: Diamond Scientific Co.
    Inventors: Gary P. Wiesehahn, Richard E. Giles, David R. Stevens
  • Photochemical decontamination treatment of whole blood or blood components
    Patent number: 4748120
    Abstract: Biological compositions are freed of functional polynucleotides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their original physiological activities and any polynucleotide present is rendered inactive.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: May 31, 1988
    Assignee: Diamond Scientific Co.
    Inventor: Gary P. Wiesehahn
  • Photochemical decontamination treatment of whole blood or blood components
    Patent number: 4727027
    Abstract: Biological compositions are decontaminated by treatment with furocoumarin derivatives and irradiation under particular conditions in which the proteins retain their original physiological activities and any pathogenic microorganisms and polynucleotide fragments thereof are rendered inactive. It has been found that reduction of the amount of dissolved oxygen in the treatment solution substantially inhibits denaturation of the proteins.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: February 23, 1988
    Assignee: Diamond Scientific Co.
    Inventors: Gary P. Wiesehahn, Richard P. Creagan
  • Preparation of inactivated viral vaccines
    Patent number: 4693981
    Abstract: Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: September 15, 1987
    Assignee: Advanced Genetics Research Institute
    Inventors: Gary P. Wiesehahn, Richard P. Creagan, David R. Stevens, Richard Giles
  • Vaccine for the prevention of vesicular stomatitis virus infection
    Patent number: 4556556
    Abstract: Novel vaccines for vesicular stomatitis virus are prepared by psoralen inactivation of the live virus under mild conditions in an inert atmosphere. The resulting inactivated virus can be used as a vaccine for inoculation of susceptible hosts to inhibit VSV infection.
    Type: Grant
    Filed: March 23, 1984
    Date of Patent: December 3, 1985
    Assignee: Advanced Genetics Research Institute
    Inventors: Gary P. Wiesehahn, Richard E. Giles, David R. Stevens
  • Psoralen inactivated double-stranded RNA viral vaccines
    Patent number: 4545987
    Abstract: Novel vaccines of double-stranded RNA viruses are prepared by psoralen inactivation under mild conditions in an inert atmosphere, optionally in the presence of a mild singlet oxygen scavenger. The resulting inactivated virus can be used as a vaccine for inoculation of hosts to provide for the stimulation of the immune system to the virus.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: October 8, 1985
    Assignee: Advanced Genetics Research Institute
    Inventors: Richard E. Giles, David R. Stevens, Gary P. Wiesehahn