Patents by Inventor Gary R. Grotendorst

Gary R. Grotendorst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Connective Tissue Growth Factor Fragments and Methods and Uses Thereof
    Publication number: 20100190838
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 2 or exon 3 of CTGF and having the ability to induce extracellular matrix synthesis, in particular, collagen synthesis and myofibroblast differentiation. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the activity of said CTGF fragments and to the compositions so identified. The invention also relates to methods of treating CTGF-associated disorders and diseases associated with the overproduction of the extracellular matrix.
    Type: Application
    Filed: April 6, 2010
    Publication date: July 29, 2010
    Inventor: Gary R. Grotendorst
  • CONNECTIVE TISSUE GROWTH FACTOR FRAGMENTS AND METHODS AND USES THEREOF
    Publication number: 20100158907
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the mitogenic activity of said CTGF fragments and to the compositions so identified.
    Type: Application
    Filed: January 15, 2010
    Publication date: June 24, 2010
    Inventors: Gary R. Grotendorst, Thomas B. Neff
  • Antibodies directed to fragments of connective tissue growth factor (CTGF) polypeptide and methods and uses thereof
    Patent number: 7718177
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 2 or exon 3 of CTGF and having the ability to induce extracellular matrix synthesis, in particular, collagen synthesis and myofibroblast differentiation. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the activity of said CTGF fragments and to the compositions so identified. The invention also relates to methods of treating CTGF-associated disorders and diseases associated with the overproduction of the extracellular matrix.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: May 18, 2010
    Assignee: University of Miami
    Inventor: Gary R. Grotendorst
  • Connective tissue growth factor
    Patent number: 7384634
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF and polynucleotides regulating CTGF expression. The invention also provides agents that modulate CTGF and therapeutic methods for using the agents. Also provided are diagnostic methods for using CTGF and assays for identifying agents which affect the expression of CTGF polynucleotide.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: June 10, 2008
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Connective tissue growth factor fragments and methods and uses thereof
    Patent number: 7115390
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the mitogenic activity of said CTGF fragments and to the compositions so identified.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: October 3, 2006
    Assignees: Fibrogen, Inc., University of Miami
    Inventors: Gary R. Grotendorst, Thomas B. Neff
  • Connective tissue growth factor fragments and methods and uses thereof
    Publication number: 20040092450
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the mitogenic activity of said CTGF fragments and to the compositions so identified.
    Type: Application
    Filed: September 9, 2003
    Publication date: May 13, 2004
    Applicants: FIBROGEN, INC., UNIVERSITY OF MIAMI
    Inventors: Gary R. Grotendorst, Thomas B. Neff
  • Connective tissue growth factor
    Publication number: 20040005319
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF and polynucleotides regulating CTGF expression. The invention also provides agents that modulate CTGF and therapeutic methods for using the agents. Also provided are diagnostic methods for using CTGF and assays for identifying agents which affect the expression of CTGF polynucleotide.
    Type: Application
    Filed: January 7, 2003
    Publication date: January 8, 2004
    Applicant: THE UNIVERSITY OF SOUTH FLORIDA
    Inventors: Gary R. Grotendorst, Douglass M. Bradham
  • Leukocyte derived growth factor 2
    Patent number: 6673893
    Abstract: A protein, Leukocyte Derived Growth Factor 2 (hereinafter LDGF2) having PDGF-like activity is described. LDGF2 reacts with PDGF receptors and possesses mitogenic and/or chemotactic activity for various cell types, particularly connective tissue cells. LDGF2 may be used as the active ingredient in therapeutic compositions, e.g. wound healing compositions, or even further may be used as an additive to cell culture media for the purpose of stimulating cell growth. The protein has a molecular weight of about 7000 daltons determined by SDS gel electrophoresis and is about 61 amino acids in length.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: January 6, 2004
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Naoko Iida
  • Connective tissue growth factor fragments and methods and uses thereof
    Publication number: 20030180300
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 2 or exon 3 of CTGF and having the ability to induce extracellular matrix synthesis, in particular, collagen synthesis and myofibroblast differentiation. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the activity of said CTGF fragments and to the compositions so identified. The invention also relates to methods of treating CTGF-associated disorders and diseases associated with the overproduction of the extracellular matrix.
    Type: Application
    Filed: December 9, 2002
    Publication date: September 25, 2003
    Inventor: Gary R. Grotendorst
  • Fragments of connective tissue growth factor that induce extracellular matrix synthesis, collagen synthesis and/or myofibroblast differentiation
    Patent number: 6492129
    Abstract: The present invention is directed to CTGF fragments comprising at least exon 2 or exon 3 of CTGF and having the ability to induce extracellular matrix synthesis, in particular, collagen synthesis and myofibroblast differentiation. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the activity of said CTGF fragments and to the compositions so identified. The invention also relates to methods of treating CTGF-associated disorders and diseases associated with the overproduction of the extracellular matrix.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: December 10, 2002
    Assignee: University of Miami
    Inventor: Gary R. Grotendorst
  • Methods and uses of connective tissue growth factor for differentiation of mesenchymal stem cells
    Patent number: 6464983
    Abstract: The present invention relates to novel methods and compositions related to the administration of connective tissue growth factor, alone or in combination with other growth factors, compositions or compounds, to induce the differentiation of mesenchymal stem cells into chondrocytes or asteablasts.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: October 15, 2002
    Assignees: University of South Florida, University of Miami
    Inventor: Gary R. Grotendorst
  • Methods of diagnosing a pathology characterized by a cell proliferative disorder associated with connective tissue growth factor
    Patent number: 6232064
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5′ and 3′ untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-&bgr; responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: May 15, 2001
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Connective tissue growth factor
    Patent number: 6190884
    Abstract: The invention relates to a method of producing connective tissue growth factor (CTGF). A method of the invention can be performed, for example, by transforming a host cell with a polynucleotide encoding a CTGF polypeptide having an amino acid sequence of SEQ ID NO: 2 or an active fragment thereof; and growing the host cells under conditions suitable for expressing the polynucleotide in the host cell. In an embodiment, the method further involves isolating the CTGF polypeptide or the active fragment. The invention also relates to a method for producing a vector containing a polynucleotide encoding a CTGF polypeptide or an active fragment thereof by inserting a polynucleotide encoding a CTGF polypeptide having an amino acid sequence of SEQ ID NO: 2 or a variant thereof into the vector. The vector can be an expression vector, for example, a plasmid expression vector or a viral expression vector. In an embodiment, the polynucleotide has a nucleotide sequence of SEQ ID NO: 1 or a variant thereof.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: February 20, 2001
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglas M. Bradham, Jr.
  • Methods of identifying a composition that alters connective tissue growth factor expression
    Patent number: 6150101
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: November 21, 2000
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Methods of accelerating wound healing or of stimulating connective tissue cell growth using connective tissue growth factor
    Patent number: 6149916
    Abstract: Connective Tissue Growth Factor (CTGF), means for producing CTGF, as well as diagnostic and therapeutic methods for using CTGF.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: November 21, 2000
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Connective tissue growth factor (CTGF) regulatory nucleic acid sequences
    Patent number: 6069006
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: May 30, 2000
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Assay of connective tissue growth factor for detection of cell proliferative disorders
    Patent number: 5916756
    Abstract: Connective Tissue Growth Factor (CTGF), means for producing CTGF, as well as diagnostic and therapeutic methods for using CTGF.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: June 29, 1999
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • DNA encoding leukocyte derived growth factor-2 (LDGF-2)
    Patent number: 5849534
    Abstract: A protein, Leukocyte Derived Growth Factor 2 (hereinafter LDGF2) having PDGF-like activity is described. LDGF2 reacts with PDGF receptors and possesses mitogenic and/or chemotactic activity for various cell types, particularly connective tissue cells. LDGF2 may be used as the active ingredient in therapeutic compositions, e.g. wound healing compositions, or even further may be used as an additive to cell culture media for the purpose of stimulating cell growth. The protein has a molecular weight of about 7000 daltons determined by SDS gel electrophoresis and is about 61 amino acids in length.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 15, 1998
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Naoko Iida
  • Induction of tissue, bone or cartilage formation using connective tissue growth factor
    Patent number: 5837258
    Abstract: The present invention relates to novel methods and compositions related to the administration of connective tissue growth factor, alone or in combination with other growth factors, compositions or compounds, to induce the formation of connective tissue, including bone, cartilage, and the skin.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: November 17, 1998
    Assignees: University of South Florida, University of Miami
    Inventor: Gary R. Grotendorst
  • Treatment of cell proliferative disorders using antibodies which bind connective tissue growth factor
    Patent number: 5783187
    Abstract: Connective Tissue Growth Factor (CTGF) is a polypeptide growth factor for connective tissue cells. CTGF is related immunologically and biologically to PDGF, but is the product of a distinct gene. CTGF, nucleic acids encoding CTGF, means for producing CTGF, anti-CTGF antibodies, diagnostic and therapeutic methods for using CTGF, and methods for inhibition or stimulation of CTGF activity are disclosed.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: July 21, 1998
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglas M. Bradham, Jr.