Patents by Inventor Gary R. Lee

Gary R. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 6-azabenzimidazole compounds
    Patent number: 11925631
    Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: March 12, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Gayatri Balan, Mark J. Bartlett, Jayaraman Chandrasekhar, Julian A. Codelli, John H. Conway, Jennifer L. Cosman, Rao V. Kalla, Musong Kim, Seung H. Lee, Jennifer R. Lo, Jennifer A. Loyer-Drew, Scott A. Mitchell, Thao D. Perry, Gary B. Phillips, Patrick J. Salvo, Joshua J. Van Veldhuizen, Suet C. Yeung, Jeff Zablocki
  • Process for synthesis of phenoxy diaminopyrimidine derivatives
    Patent number: 9643934
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: May 9, 2017
    Assignee: Roche Palo Alto LLC
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee
  • PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES
    Publication number: 20140045871
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Application
    Filed: October 14, 2013
    Publication date: February 13, 2014
    Applicant: Roche Palo Alto LLC
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee
  • Process for synthesis of phenoxy diaminopyrimidine derivatives
    Patent number: 8580960
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: November 12, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee
  • PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES
    Publication number: 20110269961
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Application
    Filed: July 12, 2011
    Publication date: November 3, 2011
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee
  • Process for synthesis of phenoxy diaminopyrimidine derivatives
    Patent number: 8003788
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: August 23, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee
  • Process for synthesis of phenoxy diaminopyrimidine derivatives
    Patent number: 7741484
    Abstract: A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: June 22, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Anton Constantinescu, Keena Lynn Green, Eric Roy Humphreys, Gary R. Lee, Patrick Finbar McGarry
  • Process for the preparation of 3-amino-pentan-1,5-diol
    Patent number: 7635784
    Abstract: The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: December 22, 2009
    Assignees: Hoffmann-La Roche Inc., Roche Palo Alto LLC
    Inventors: Thomas Cleary, Yaohui Ji, Gary R. Lee, Thimma Rawalpally, Keshab Sarma
  • NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO-PENTAN-1,5-DIOL
    Publication number: 20080312467
    Abstract: The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.
    Type: Application
    Filed: June 9, 2008
    Publication date: December 18, 2008
    Inventors: Thomas Cleary, Yaohui Ji, Gary R. Lee, Thimma Rawalpally, Keshab Sarma
  • Process for synthesis of phenoxy diaminopyrimidine derivatives
    Publication number: 20080086004
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Application
    Filed: October 4, 2007
    Publication date: April 10, 2008
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee