Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: A modular system and method for improving the receiving, processing, storing, and transloading of bulk materials such as organic waste. A system includes at least a receiving module to receive material, a storage module, a discharge module, and a control system. A liquid capture system captures and retains liquid from the organic material. Systems can be adapted with additional modules, such as processing modules and transfer modules, depending on the site and materials to be handled. The storage module has a levelling component for levelling out the organic material stored therein, including a levelling conveyor in a top region, and a removal component for discharging the organic material. A control system interfaces with the modular components and local operators, and provides remote reporting and monitoring.

Abstract: In various embodiments, a targeting guide is disclosed. The targeting guide includes a handle defining a targeting hole and a targeting tower configured to be coupled to the handle. The targeting tower defines at least a first guide hole and a second guide hole. Each of the first and second guide holes are sized and configured to receive a respective first guide pin and second guide pin therethrough. The first and second guide pins are configured to indicate alignment of a k-wire inserted through the targeting hole defined by the handle. Methods of using a targeting guide are also disclosed.

Abstract: An instrument for use in cartilage removal comprises an elongate body having a first end and a longitudinal axis having a longitudinal direction. A cartilage removal portion is coupled to the elongate body at the first end. The cartilage removal portion includes a plurality of serrated blades substantially perpendicular to the longitudinal axis and adapted for removing material while moving in the longitudinal direction. Each serrated blade has a centroid located along the longitudinal axis.

Abstract: In an embodiment, schedule layers are generated. Each schedule layer has one or more schedule entries and a precedence value. At least one schedule layer includes schedule entries that are generated in a repetitive fashion according to an epoch. A final schedule is created based on a combination of the schedule layers according to an ordering of the precedence value of respective schedule layers. Creating the final schedule includes identifying a gap in the final schedule; and filling the gap using a schedule entry from a schedule layer of the two or more schedule layers selected according to respective precedence values. A real time interface is employed to visually present the final schedule for display. The real time interface is configured to dynamically transform and render the one or more schedule entries into one or more graphical cells visually distinguished from each other based restrictions, team members, or inputs.

Abstract: The present invention discloses an industrial high speed micro drill that is made to access remote and inaccessible locations in order to blend, grind, polish and cut materials and parts as determined by visual inspection powered via a pneumatic power source. The high speed drill is deployed by a controlled, articulating guide tube that acts in a multidirectional fashion to direct the action of the assemblage and allow for discrete manipulation of the pneumatically powered drill while harboring a channel and pneumatic power source carrying rubber tubing.

Abstract: Embodiments are directed towards generating and managing schedules. In at least one of the various embodiments, these schedules may be configured to schedule team members, rotating which team member is active (“on-call”). In at least one of the various embodiments, these may be employed to determine which resource is responsible to respond and/or resolve incidents that may be reported and/or detected. In at least one of the various embodiments, if a team member is determined to be the on-call or responsible team member, the notification engine may determine the methods for notify the responsible of the incidents. Schedules previews may be updated in real-time as the schedule is edited.

Abstract: Embodiments are directed towards generating and managing schedules. In at least one of the various embodiments, these schedules may be configured to schedule team members, rotating which team member is active (“on-call”). In at least one of the various embodiments, these may be employed to determine which resource is responsible to respond and/or resolve incidents that may be reported and/or detected. In at least one of the various embodiments, if a team member is determined to be the on-call or responsible team member, the notification engine may determine the methods for notify the responsible of the incidents. Schedules previews may be updated in real-time as the schedule is edited.

Abstract: The present invention discloses an industrial high speed micro drill that is made to access remote and inaccessible locations in order to blend, grind, polish and cut materials and parts as determined by visual inspection powered via a pneumatic power source. The high speed drill is deployed by a controlled, articulating guide tube that acts in a multidirectional fashion to direct the action of the assemblage and allow for discrete manipulation of the pneumatically powered drill while harboring a channel and pneumatic power source carrying rubber tubing.

Abstract: Embodiments are directed towards generating and managing schedules. In at least one of the various embodiments, these schedules may be configured to schedule team members, rotating which team member is active (“on-call”). In at least one of the various embodiments, these may be employed to determine which resource is responsible to respond and/or resolve incidents that may be reported and/or detected. In at least one of the various embodiments, if a team member is determined to be the on-call or responsible team member, the notification engine may determine the methods for notify the responsible of the incidents. Schedules previews may be updated in real-time as the schedule is edited.

Abstract: The present invention discloses an industrial high speed micro drill that is made to access remote and inaccessible locations in order to blend, grind, polish and cut materials and parts as determined by visual inspection powered via a pneumatic power source. The high speed drill is deployed by a controlled, articulating guide tube that acts in a multidirectional fashion to direct the action of the assemblage and allow for discrete manipulation of the pneumatically powered drill while harboring a channel and pneumatic power source carrying rubber tubing.

Abstract: Embodiments are directed towards generating and managing schedules. In at least one of the various embodiments, these schedules may be configured to schedule team members, rotating which team member is active (“on-call”). In at least one of the various embodiments, these may be employed to determine which resource is responsible to respond and/or resolve incidents that may be reported and/or detected. In at least one of the various embodiments, if a team member is determined to be the on-call or responsible team member, the notification engine may determine the methods for notify the responsible of the incidents. Schedules previews may be updated in real-time as the schedule is edited.

Abstract: Embodiments are directed towards a notification message system arranged to generate notification messages. Responsible resources may be determined based on the notification messages and a schedule. A plurality of message providers that have a provider profiles may be determined based on the responsible resources and a region. A message provider from the plurality of message providers may be determined based on its provider profile. The notification messages may be provided to the message provider so they can be provided to the responsible resources. The provider profiles may be updated based on performance metrics associated with the message provider.

Abstract: A beam (20) comprising first and second flanges (23, 24), the beam (20) having a first region (28, 30) extending between the flanges (23, 24) and a second region (26) extending between the flanges. The first region (28, 30) is designed to support an applied concentrated shear load and the second region (26) is designed to support a predominantly bending load. The first region comprises a fan-shaped truss comprising a hub (36) adjacent the first flange and a plurality of struts (37) which extend substantially radially from the hub (36), and the second region (26) comprises either a truss structure which is substantially regular in the longitudinal beam direction or a shear web. The beam may, for example, be used as a floor beam for an aircraft fuselage.

Abstract: An exhaust processing unit includes a selective catalytic reduction apparatus which processes exhaust from an engine. A reducing agent injection apparatus is attached to the exhaust processing unit. The reducing agent injection apparatus injects a reducing agent which is supplied to the selective catalytic reduction apparatus. The reducing agent tank and the reducing agent supply pump are arranged outside the engine compartment. The reducing agent tank retains the reducing agent. The reducing agent supply pump supplies the reducing agent from the reducing agent tank to the reducing agent injection apparatus. The reducing agent pipe connects the reducing agent supply pump and the reducing agent injection apparatus. The revolving frame includes a pipe frame. The reducing agent pipe is arranged from the reducing agent supply pump to the reducing agent injection apparatus so as to pass through the inner space of the pipe frame.

Abstract: Embodiments are directed towards generating and managing schedules. In at least one of the various embodiments, these schedules may be configured to schedule team members, rotating which team member is active (“on-call”). In at least one of the various embodiments, these may be employed to determine which resource is responsible to respond and/or resolve incidents that may be reported and/or detected. In at least one of the various embodiments, if a team member is determined to be the on-call or responsible team member, the notification engine may determine the methods for notify die responsible of the incidents. Schedules previews may be updated in real-time as the schedule is edited.

Abstract: An exhaust processing unit includes a selective catalytic reduction apparatus which processes exhaust from an engine. A reducing agent injection apparatus is attached to the exhaust processing unit. The reducing agent injection apparatus injects a reducing agent which is supplied to the selective catalytic reduction apparatus. The reducing agent tank and the reducing agent supply pump are arranged outside the engine compartment. The reducing agent tank retains the reducing agent. The reducing agent supply pump supplies the reducing agent from the reducing agent tank to the reducing agent injection apparatus. The reducing agent pipe connects the reducing agent supply pump and the reducing agent injection apparatus. The revolving frame includes a pipe frame. The reducing agent pipe is arranged from the reducing agent supply pump to the reducing agent injection apparatus so as to pass through the inner space of the pipe frame.

Abstract: Embodiments are directed towards generating schedules for managing team members that may be responsible to be on-call for responding to incidents. Schedules may be configured to schedule team members and manage the rotation of one or more team members assigned to one or more schedule layers. Also, schedules may be employed to determine which team member may be responsible to respond and/or resolve incidents that may be reported and/or detected. If a team member is determined to be the on-call or responsible team member, a notification engine may determine the methods for notify the responsible of the incidents. Further, the notification engine may monitor whether the responsible team has received the notification. The notification engine may employ one or more other notification methods to ensure that the responsible team member may be notified.

Abstract: Embodiments are directed towards generating schedules for managing team members that may be responsible to be on-call for responding to incidents. Schedules may be configured to schedule team members and manage the rotation of one or more team members assigned to one or more schedule layers. Also, schedules may be employed to determine which team member may be responsible to respond and/or resolve incidents that may be reported and/or detected. If a team member is determined to be the on-call or responsible team member, a notification engine may determine the methods for notify the responsible of the incidents. Further, the notification engine may monitor whether the responsible team has received the notification. The notification engine may employ one or more other notification methods to ensure that the responsible team member may be notified.

Abstract: Embodiments are directed towards generating and managing schedules. In at least one of the various embodiments, these schedules may be configured to schedule team members, rotating which team member is active (“on-call”). In at least one of the various embodiments, these may be employed to determine which resource is responsible to respond and/or resolve incidents that may be reported and/or detected. In at least one of the various embodiments, if a team member is determined to be the on-call or responsible team member, the notification engine may determine the methods for notify the responsible of the incidents. Schedules previews may be updated in real-time as the schedule is edited.