Patents by Inventor Gary Skarja

Gary Skarja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR COUPLING A LIGAND TO A COMPOSITE MATERIAL
    Publication number: 20220410076
    Abstract: Disclosed are methods for coupling a ligand to a composite material. Covalent bonds are formed between functionalized composite materials and ligands as a ligand solution flows through or across the composite materials. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: November 20, 2020
    Publication date: December 29, 2022
    Inventors: Matthew T. Stone, Santosh Rahane, Joaquin A. Umana, Gary Skarja, Elena N. Komkova, Melissa Vandersluis, Amro Ragheb
  • SUPERCRITICAL DRYING OF CHROMATOGRAPHIC MEDIA
    Publication number: 20220341664
    Abstract: Disclosed are methods for critical point drying a composite material. After exposing the composite material to a supercritical fluid, the composite material dries as the supercritical fluid evaporates with reduced pressure. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: September 14, 2020
    Publication date: October 27, 2022
    Inventors: John Boyle, Gary Skarja, Amro Ragheb
  • Methods of separating substances from fluids
    Patent number: 11383229
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: July 12, 2022
    Assignee: Merck Millipore Ltd.
    Inventors: Amro Ragheb, Gary Skarja
  • METHODS OF SEPARATING SUBSTANCES FROM FLUIDS
    Publication number: 20210060541
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: November 11, 2020
    Publication date: March 4, 2021
    Inventors: Amro Ragheb, Gary Skarja
  • Methods of separating substances from fluids
    Patent number: 10864510
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: December 15, 2020
    Assignee: Merck Millipore Ltd.
    Inventors: Amro Ragheb, Gary Skarja
  • CHROMATOGRAPHY MEMBRANES FORMED BY THIOL-ENE OR THIOL-YNE CLICK POLYMERIZATION REACTIONS
    Publication number: 20200047175
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: July 19, 2019
    Publication date: February 13, 2020
    Inventors: Amro Ragheb, Gary Skarja
  • Chromatography membranes formed by thiol-ene or thiol-yne click polymerization reactions
    Patent number: 10357766
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: July 23, 2019
    Assignee: Natrix Separations Inc.
    Inventors: Amro Ragheb, Gary Skarja
  • CHROMATOGRAPHY MEMBRANES FORMED BY THIOL-ENE OR THIOL-YNE CLICK POLYMERIZATION REACTIONS
    Publication number: 20180297023
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 18, 2018
    Inventors: Amro Ragheb, Gary Skarja
  • Chromatography membranes formed by thiol-ene or thiol-yne click polymerization reactions
    Patent number: 9962691
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: May 8, 2018
    Assignee: Natrix Separations Inc.
    Inventors: Amro Ragheb, Gary Skarja
  • Chromatography Membranes Formed by Thiol-Ene or Thiol-Yne Click Polymerization Reactions
    Publication number: 20160243538
    Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 25, 2016
    Inventors: Amro Ragheb, Gary Skarja
  • Therapeutic Polymeric Pouch
    Publication number: 20080199507
    Abstract: An implantable or surface-applied device comprising a porous polymeric pouch containing a therapeutic polymer sealed in the pouch, to provide a localized therapeutic effect at the site of the application. The pores in the polymeric pouch being smaller than the therapeutic polymer, allowing body fluid to enter and exit the pouch and interact with the therapeutic polymer in the pouch in use, but not permitting the therapeutic polymer to leave the pouch.
    Type: Application
    Filed: June 19, 2006
    Publication date: August 21, 2008
    Applicant: RIMON THERAPEUTICS LTD.
    Inventors: Gary A. Skarja, Rebecca K. Ho, Michael H. May
  • Hydroxyamate-containing materials for the inhibition of matrix metalloproteinases
    Publication number: 20070160655
    Abstract: Therapeutic polymers containing a hydroxamate group that preferentially binds to active forms of a matrix metalloproteinases, thus inhibiting their enzymatic activity. The implantation of such material modifies tissue turnover and remodelling in its vicinity.
    Type: Application
    Filed: March 7, 2007
    Publication date: July 12, 2007
    Inventors: Michael Sefton, Michael May, Gary Skarja, Allison Brown
  • Ancient defense polymer
    Publication number: 20070104678
    Abstract: The invention relates to an ancient defense polymer having biological activity. The polymer comprises both discrete hydrophilic blocks containing cationic charge(s) and discrete hydrophobic blocks, making it amphipathic and antimicrobial in a manner analogous to natural antimicrobial peptides that form an ancient defense mechanism employed by many organisms. Such a polymer may be formed into devices designed to resist infection or bound to the surface of an apparatus to lend the biological activity to the surface of the apparatus.
    Type: Application
    Filed: April 7, 2004
    Publication date: May 10, 2007
    Inventors: Michael May, Gary Skarja
  • Hydroxyamate-containing materials for the inhibition of matrix metalloproteinases
    Publication number: 20040213758
    Abstract: Therapeutic polymers containing hydroxamate group that binds and thus inhibits zinc containing enzymes such as matrix metalloproteinases. The implantation of such material inhibits remodeling in its vicinity.
    Type: Application
    Filed: April 23, 2003
    Publication date: October 28, 2004
    Applicant: Rimon Therapeutics Ltd.
    Inventors: Michael V. Sefton, Michael H. May, Gary A. Skarja
  • Incorporation by reference of co-pending application
    Publication number: 20020115814
    Abstract: Disclosed herein is a biodegradable polyurethane material having a backbone containing at least one amino acid group. The amino acid group is in a condition rending it recognizable by a biological agent.
    Type: Application
    Filed: February 5, 2001
    Publication date: August 22, 2002
    Inventors: Kimberly Ann Woodhouse, Gary Skarja