Abstract: A continuous reaction system (CRS) allows a method to prepare quantum dots (QDs) in a continuous manner with high precision. The CRS pumps a plurality of reagent fluids into one or more mixing sites to form a reaction fluid that is carried through a heating chamber at elevated pressures to carry out hydrothermal growth of the QDs. The pumps and heating chamber are controlled with a high precision by employing a detector downstream of the heating chamber to provide a signal that is dependent on the composition and size of the QDs. The signal is provided to a signal processor that provides a signal that control the flow rates and temperature parameters in the system. The QDs produced in this manner are consistent in size and composition and can be of a single semiconductor composition or can be core-shell QDs with a shell semiconductor formed on a core semiconductor.

Abstract: A continuous reaction system (CRS) allows a method to prepare quantum dots (QDs) in a continuous manner with high precision. The CRS pumps a plurality of reagent fluids into one or more mixing sites to form a reaction fluid that is carried through a heating chamber at elevated pressures to carry out hydrothermal growth of the QDs. The pumps and heating chamber are controlled with a high precision by employing a detector downstream of the heating chamber to provide a signal that is dependent on the composition and size of the QDs. The signal is provided to a signal processor that provides a signal that control the flow rates and temperature parameters in the system. The QDs produced in this manner are consistent in size and composition and can be of a single semiconductor composition or can be core-shell QDs with a shell semiconductor formed on a core semiconductor.

Abstract: In accordance with the invention there are systems and methods of preparing surface enhanced Raman spectroscopy substrate and methods of enhanced detection of an analyte.

Abstract: An apparatus for classifying a mixture of fine and coarse particles in a fluid stream by size or density comprises a housing, a boundary layer momentum transfer device, and an inlet flow control mechanism. The housing comprises an inlet, an interior chamber, and a fine particle outlet. The boundary layer momentum transfer device comprises a plurality of disks stacked in spaced, parallel relation in the interior chamber. The disks are rotatable about a disk axis. The disks have respective central openings cooperatively defining a plenum having a closed axial end and an opposing open axial end. The plenum communicates with spaces defined between each adjacent disk to cooperatively define a fine particle flow path from the interior chamber, through the spaces, through the plenum and the open axial end thereof, and to the fine particle outlet. The inlet flow control mechanism communicates with the interior chamber and provides an adjustable inlet flow path into the interior chamber.

Abstract: An apparatus for classifying a mixture of fine and coarse particles in a fluid stream by size or density comprises a housing, a boundary layer momentum transfer device, and an inlet flow control mechanism. The housing comprises an inlet, an interior chamber, and a fine particle outlet. The boundary layer momentum transfer device comprises a plurality of disks stacked in spaced, parallel relation in the interior chamber. The disks are rotatable about a disk axis. The disks have respective central openings cooperatively defining a plenum having a closed axial end and an opposing open axial end. The plenum communicates with spaces defined between each adjacent disk to cooperatively define a fine particle flow path from the interior chamber, through the spaces, through the plenum and the open axial end thereof, and to the fine particle outlet. The inlet flow control mechanism communicates with the interior chamber and provides an adjustable inlet flow path into the interior chamber.