Abstract: A method, apparatus and computer program product are provided in order to provide intelligent gap placement within mobility data using junctions inferred by features of the mobility data. In this regard, a sequence of location probe data points representative of travel of a vehicle along a portion of a road network during an interval of time is received. Additionally, junction behavior in the sequence of location probe data points is identified based on one or more features for the sequence of location probe data points. Based on a junction point that corresponds to a location probe data point immediately after a last probe data point in the junction, a gap placement in the sequence of location probe data points to generate at least a first subsequence of the location probe data points and a second subsequence of the location probe data points.

Abstract: A method, apparatus and computer program product are provided in order to provide intelligent trajectory configurations within mobility data using junctions inferred by features of the mobility data. In this regard, a sequence of location probe data points representative of travel of a vehicle along a portion of a road network during an interval of time is received. Additionally, junction behavior in the sequence of location probe data points is identified based on one or more features for the sequence of location probe data points. Based on the junction behavior, a last probe data point of a first sub-trajectory for the trajectory and a first probe data point of a second sub-trajectory for the trajectory, a gap placement is applied in the sequence of location probe data points to generate at least a first subsequence of the location probe data points and a second subsequence of the location probe data points.

Abstract: A method, apparatus and computer program product are provided in order to provide at least approximate real-time intelligent gap placement within mobility data using junctions inferred by features of the mobility data. In this regard, a data chunk associated with a sequence of location probe data points representative of travel of a vehicle along a portion of a road network is received. Additionally, junction behavior in the data chunk is identified based on one or more features for the sequence of location probe data points. Based on a status of a previous data chunk and a junction point that corresponds to a location probe data point immediately after a last probe data point in the junction, a gap placement or a sub-trajectory is applied in the sequence of location probe data points to generate at least a first subsequence and second subsequence of the location probe data points.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.

Abstract: The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also related to new methods of characterising target polynucleotides.

Abstract: The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.

Abstract: A method of treating exhaust gas from a lean burn internal combustion engine is disclosed. The method comprises: introducing ammonia or an ammonia precursor into the exhaust gas upstream of an Fe-SCR catalyst, the Fe-SCR catalyst comprising iron and a zeolite; and contacting the exhaust gas with the Fe-SCR catalyst; wherein the amount of ammonia or ammonia precursor introduced into the exhaust gas upstream of the Fe-SCR catalyst is controlled to provide an ammonia-to-NOx molar ratio (ANR) in the exhaust gas contacting the Fe-SCR catalyst of from greater than 2 to 6.

Abstract: Embodiments described herein relate to anonymizing of trajectories of mobile devices. Methods may include: receiving an input chunk of probe data points, where the input chunk includes probe data points spanning an input duration, where the input chunk represents at least a first input portion of a trajectory; generating, based at least in part on the input chunk, an output chunk of one or more probe data points, where the output chunk includes one or more probe data points spanning an output duration, where the output duration is different from the input duration, where the output chunk represents at least an output portion of the trajectory, where the first input portion of the trajectory and the output portion of the trajectory share at least a common portion of the trajectory; and providing the output chunk of one or more probe data points to a location-based service provider.

Abstract: The invention provides a method of selectively characterising polynucleotides of a desired property, such as length, using a nanopore, based on the translocation of the polynucleotide through or across the nanopore. Kits and systems for use in such methods are also provided. The methods of the invention are particularly suitable for sequencing polynucleotides such as DNA.

Abstract: Embodiments described herein relate to anonymizing of trajectories of mobile devices through the obfuscation of stay points. Methods may include: receiving probe data points of a trajectory in real-time or near real-time from a probe apparatus as it travels along the trajectory; calculating, for each probe data point, a probability of the trajectory reaching a stay point within a predetermined distance; providing sequential sub-sets of probe data points of the trajectory to a location-based service provider in response to the sequential sub-sets of probe data points including probe data points having a probability failing to satisfy a predetermined value; and identifying a last sub-set of probe data points of the sequential sub-sets of probe data points to provide to the location-based service provider in response to identifying a probe data point having a probability of the trajectory reaching a stay point within the predetermined distance satisfying the predetermined value.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

Abstract: The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

Abstract: The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also related to new methods of characterising target polynucleotides.

Abstract: An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.