Patents by Inventor Gavin J. C. Braithwaite
Gavin J. C. Braithwaite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9394384Abstract: The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making crosslinked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.Type: GrantFiled: September 27, 2005Date of Patent: July 19, 2016Assignee: The General Hospital CorporationInventors: Orhun K. Muratoglu, Jeeyoung Choi, Hatice Bodugoz-Senturk, Gavin J. C. Braithwaite, Stephen H. Spiegelberg
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Patent number: 8637063Abstract: The invention provides methods of making hydrolyzed cross-linked polyvinyl alcohol (PVA) hydrogels by polymerizing vinyl acetate (VAc) monomers to polyvinyl acetate (PVAc) polymer network by chemical-crosslinking and hydrolysis. The invention also provides methods for including pendant chains in the hydrogel during the polymerization process. Materials produced and use of the cross-linked hydrolyzed PVA hydrogels also are disclosed herein.Type: GrantFiled: December 7, 2009Date of Patent: January 28, 2014Assignee: Cambridge Polymer Group, Inc.Inventors: Edward T. Kopesky, Jason Berlin, Martin F. Van Buren, Gavin J. C. Braithwaite
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Publication number: 20110256201Abstract: The invention provides methods of making hydrolyzed cross-linked polyvinyl alcohol (PVA) hydrogels by polymerizing vinyl acetate (VAc) monomers to polyvinyl acetate (PVAc) polymer network by chemical-crosslinking and hydrolysis. The invention also provides methods for including pendant chains in the hydrogel during the polymerization process. Materials produced and use of the cross-linked hydrolyzed PVA hydrogels also are disclosed herein.Type: ApplicationFiled: December 7, 2009Publication date: October 20, 2011Applicant: CAMBRIDGE POLYMER GROUP, INC.Inventors: Edward T. Kopesky, Jason A. Berlin, Martin F. Van Buren, Gavin J.C. Braithwaite
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Patent number: 7776352Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: August 7, 2006Date of Patent: August 17, 2010Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Patent number: 7745532Abstract: The preferred embodiments of the present invention provide polymer compositions and methods for controlling a property of a resultant gel. A preferred method includes dissolving a vinyl polymer in a first solvent to form a solution; and contacting the vinyl polymer solution in a suitable volume of at least one immersion solvent comprising a second solvent to cause gelation. In preferred embodiments, the invention provides poly(vinyl alcohol) compositions and methods that produce physically crosslinked hydrogels that have tunable physical properties. Also provided are articles of manufacture such as prosthetic intervertebral disks and contact lenses.Type: GrantFiled: July 31, 2003Date of Patent: June 29, 2010Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Patent number: 7619009Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: August 7, 2006Date of Patent: November 17, 2009Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Patent number: 7485670Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: February 4, 2004Date of Patent: February 3, 2009Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Publication number: 20080274161Abstract: The invention provides fabricated hydrogels, hydrogel particles, hydrogel containing compositions, and methods of making the same. The invention also provides methods of implanting, injecting, or administering the hydrogels, hydrogel particles, or the hydrogel containing compositions to treat a subject in need. Methods of crosslinking pre-solidified or pre-gelled hydrogel particles and making crosslinked hydrogels, crosslinked hydrogel particles, and crosslinked hydrogel containing compositions also are disclosed herein.Type: ApplicationFiled: May 18, 2006Publication date: November 6, 2008Inventors: Orhun K. Muratoglu, Gavin J. C. Braithwaite, Jeeyoung Choi, Stephen H. Spiegelberg
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Publication number: 20080208347Abstract: The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.Type: ApplicationFiled: September 27, 2005Publication date: August 28, 2008Inventors: Orhun K. Muratoglu, Jeeyoung Choi, Hatice Bodugoz-Senturk, Gavin J.C. Braithwaite, Stephen H. Spiegelberg
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Patent number: 7048963Abstract: This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.Type: GrantFiled: November 27, 2002Date of Patent: May 23, 2006Assignee: Cambridge Polymers Group, Inc.Inventors: Gavin J. C. Braithwaite, Jeffrey W. Ruberti
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Publication number: 20040171740Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: ApplicationFiled: February 4, 2004Publication date: September 2, 2004Applicant: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Publication number: 20040092653Abstract: The preferred embodiments of the present invention provide polymer compositions and methods for controlling a property of a resultant gel. A preferred method includes dissolving a vinyl polymer in a first solvent to form a solution; and contacting the vinyl polymer solution in a suitable volume of at least one immersion solvent comprising a second solvent to cause gelation. In preferred embodiments, the invention provides poly(vinyl alcohol) compositions and methods that produce physically crosslinked hydrogels that have tunable physical properties. Also provided are articles of manufacture such as prosthetic intervertebral disks and contact lenses.Type: ApplicationFiled: July 31, 2003Publication date: May 13, 2004Applicant: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J.C. Braithwaite
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Patent number: 6711941Abstract: Apparatus and methods for evaluating the rheological properties of Newtonian and non-Newtonian liquids and melts employs the principle of capillary breakup following rapid stretching of the fluid between two plates. The apparatus includes opposed surfaces defining a sample site disposed therebetween. A liquid sample undergoes an extensional deformation between the opposed surfaces which separate using a user-defined motion profile. The time profile of the diameter of the liquid filament is monitored and recorded as a function of time. Preferred embodiments of the present invention include data analysis of the diameter of the filament as a function of time which provides information regarding rheological parameters including, but not limited to, extensional viscosity versus strain.Type: GrantFiled: August 13, 2001Date of Patent: March 30, 2004Assignee: Cambridge Polymer Group, Inc.Inventors: Gavin J. C. Braithwaite, Stephen H. Spiegelberg, Gareth H. McKinley
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Publication number: 20030141618Abstract: This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.Type: ApplicationFiled: November 27, 2002Publication date: July 31, 2003Applicant: Cambridge Polymer Group, Inc.Inventors: Gavin J. C. Braithwaite, Jeffrey W. Ruberti
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Publication number: 20020183851Abstract: The present invention provides a system and a method for reducing pores, or air pockets, that form at the interface between the material used to attach or adhere the surface of a component, such as a prosthesis, to a site.Type: ApplicationFiled: March 19, 2002Publication date: December 5, 2002Applicant: Cambridge Polymer Group, Inc.Inventors: Stephen H. Spiegelberg, Jeffrey W. Ruberti, Gavin J.C. Braithwaite
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Publication number: 20020116987Abstract: Apparatus and methods for evaluating the rheological properties of Newtonian and non-Newtonian liquids and melts employs the principle of capillary breakup following rapid stretching of the fluid between two plates.Type: ApplicationFiled: August 13, 2001Publication date: August 29, 2002Inventors: Gavin J.C. Braithwaite, Stephen H. Spiegelberg, Gareth H. McKinley