Patents by Inventor Gavin M. Cree

Gavin M. Cree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds
    Patent number: 4426453
    Abstract: Novel amides of an iodothyronine compound such as tri-iodothyronine (T3) or thyroxine (T4) with an aminoacetic acid compound such as nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA) or diethylenetriamine pentaacetic acid (DTPA) may be labelled, e.g. radioactively labelled with I-125, to give labelled derivatives useful in assays of a free thyroid hormone in a biological fluid which also contains the thyroid hormone bound to one or more natural binders. The novel compound T4 EDTA is shown to bind much more strongly to antibodies to T4 than to the natural protein binders in the biological fluid.
    Type: Grant
    Filed: August 27, 1981
    Date of Patent: January 17, 1984
    Assignee: Amersham International Limited
    Inventors: Gavin M. Cree, Terence A. Wilkins, Reginald Monks, David P. Nowotnik
  • Selenium derivatives of thyroxine and tri-iodothyronine
    Patent number: 4311853
    Abstract: Novel Selenium derivatives of thyroxine and tri-iodothyronine have the formula: ##STR1## wherein M is I or H and either (a) R.sub.1 is OH or a carboxyl protecting group and R.sub.2 contains at least one Se, preferably .sup.75 Se, atom or (b) R.sub.2 is H or an amino protecting group and R.sub.1 contains at least one Se, preferably .sup.75 Se, atom.The compounds are useful in dual isotope assays of thyroid function.
    Type: Grant
    Filed: January 30, 1980
    Date of Patent: January 19, 1982
    Assignee: The Radiochemical Centre Limited
    Inventor: Gavin M. Cree