Patents by Inventor Genevieve C. van de Bittner

Genevieve C. van de Bittner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LUCIFERIN DERIVATIVES FROM BICYCLIC REACTANTS AND AMINOTHIOL DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20190290784
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Application
    Filed: June 13, 2019
    Publication date: September 26, 2019
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
  • Luciferin derivatives from bicyclic reactants and aminothiol derivatives and methods of use thereof
    Patent number: 10328161
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 25, 2019
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
  • LUCIFERIN DERIVATIVES FROM BICYCLIC REACTANTS AND AMINOTHIOL DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20160015835
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Application
    Filed: September 25, 2015
    Publication date: January 21, 2016
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
  • Luciferin derivatives from bicyclic reactants and aminothiol derivatives and methods of use thereof
    Patent number: 9173966
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: November 3, 2015
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
  • Fluorescent probes for detection of copper
    Patent number: 8865914
    Abstract: The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 21, 2014
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Genevieve C. Van De Bittner, Tasuku Hirayama, Jefferson Chan
  • Compounds and Methods for Detecting Reactive Oxygen Species
    Publication number: 20130315829
    Abstract: The present disclosure provides compounds that detect reactive oxygen species in a living cell, in a multicellular organism, or in a cell-free sample. The compounds find use in a variety of applications, which are also provided. The present disclosure provides compositions comprising a subject compound.
    Type: Application
    Filed: April 21, 2011
    Publication date: November 28, 2013
    Applicant: The Regents of the University of California
    Inventors: Christopher J. Chang, Genevieve C. van de Bittner, Elena A. Dubikovskaya, Carolyn R. Bertozzi
  • Luciferin Derivatives from Bicyclic Reactants and Aminothiol Derivatives and Methods of Use Thereof
    Publication number: 20130287699
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Application
    Filed: January 15, 2013
    Publication date: October 31, 2013
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya