Patents by Inventor Gentao Liu

Gentao Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion protein for restoring the functions of failing immune cells and application thereof
    Patent number: 10815303
    Abstract: A fusion protein for restoring functions of failing immune cells and application thereof. The fusion protein has a functional area for recognizing the failing immune cell and a functional area for conducting activation and amplification on the failing immune cell. The two functional areas are connected through a non-functional amino acid fragment with a certain length. The functional area for recognition uses the immune checkpoint specific antibody to recognize a phenotypic receptor of failing immune cells. The functional area for conducting activation and amplification adopts the cytokine or functionally-similar mutants, a ligand of the phenotypic receptor or functionally-similar mutants or an activating antibody to activate failing immune cells.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 27, 2020
    Assignee: Shanghai Biomed-Union Biotechnology Co., Ltd.
    Inventors: Xilian Yue, Gentao Liu, Guoxiang Wu
  • FUSION PROTEIN FOR RESTORING THE FUNCTIONS OF FAILING IMMUNE CELLS AND APPLICATION THEREOF
    Publication number: 20200040080
    Abstract: A fusion protein for restoring functions of failing immune cells and application thereof. The fusion protein has a functional area for recognizing the failing immune cell and a functional area for conducting activation and amplification on the failing immune cell. The two functional areas are connected through a non-functional amino acid fragment with a certain length. The functional area for recognition uses the immune checkpoint specific antibody to recognize a phenotypic receptor of failing immune cells. The functional area for conducting activation and amplification adopts the cytokine or functionally-similar mutants, a ligand of the phenotypic receptor or functionally-similar mutants or an activating antibody to activate failing immune cells.
    Type: Application
    Filed: April 7, 2017
    Publication date: February 6, 2020
    Inventors: Xilian YUE, Gentao LIU, Guoxiang WU
  • Cancer vaccines and vaccination methods
    Patent number: 10226519
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: March 12, 2019
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20170173130
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: August 3, 2016
    Publication date: June 22, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • CD133 EPITOPES
    Publication number: 20170088601
    Abstract: An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO:1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO:1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO:13). The immunogens can be used in compositions and in the treatment of disorders.
    Type: Application
    Filed: May 24, 2016
    Publication date: March 30, 2017
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: John S. Yu, Keith L. Black, Gentao Liu
  • Cancer vaccines and vaccination methods
    Patent number: 9433667
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: September 6, 2016
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • CD133 epitopes
    Patent number: 9382308
    Abstract: An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO: 1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO: 1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO: 13). The immunogens can be used in compositions and in the treatment of disorders.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 5, 2016
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Keith L. Black, Gentao Liu
  • Cancer vaccines and vaccination methods
    Patent number: 9095538
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 4, 2015
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • CD133 epitopes
    Patent number: 9068020
    Abstract: An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO:1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO:1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO:13). The immunogens can be used in compositions and in the treatment of disorders.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: June 30, 2015
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Keith L. Black, Gentao Liu
  • Cancer vaccines and vaccination methods
    Patent number: 8871211
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 28, 2014
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20120156232
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 21, 2012
    Inventors: John S. Yu, Gentao Liu, Keith L. Black, Clemencia Pinilla
  • Cancer vaccines and vaccination methods
    Patent number: 8097256
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: January 17, 2012
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • CD133 Epitopes
    Publication number: 20100135975
    Abstract: An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO:1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO:1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO:13). The immunogens can be used in compositions and in the treatment of disorders.
    Type: Application
    Filed: September 2, 2009
    Publication date: June 3, 2010
    Inventors: John S. Yu, Keith L. Black, Gentao Liu
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20080311141
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: September 28, 2007
    Publication date: December 18, 2008
    Inventors: John S. YU, Gentao LIU, Keith L. BLACK
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20080311142
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: September 28, 2007
    Publication date: December 18, 2008
    Inventors: John S. Yu, Gentao Liu, Keith L. Black, Clemencia Pinilla