Patents by Inventor Geoff G. Z. Zhang

Geoff G. Z. Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt and crystalline forms thereof of a drug
    Patent number: 10329276
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: June 25, 2019
    Assignee: ABBVIE INC.
    Inventors: Geoff G. Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • SALT AND CRYSTALLINE FORMS THEREOF OF A DRUG
    Publication number: 20180105510
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Application
    Filed: December 18, 2017
    Publication date: April 19, 2018
    Inventors: Geoff G.Z. ZHANG, Michael F. BRADLEY, David M. BARNES, Rodger HENRY
  • Salt and crystalline forms thereof of a drug
    Patent number: 9873681
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: January 23, 2018
    Assignee: ABBVIE INC.
    Inventors: Geoff G. Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • SALT AND CRYSTALLINE FORMS THEREOF OF A DRUG
    Publication number: 20170073329
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Inventors: Geoff G.Z. ZHANG, Michael F. BRADLEY, David M. BARNES, Rodger HENRY
  • Salt and crystalline forms thereof of a drug
    Patent number: 9539250
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: January 10, 2017
    Assignee: ABBVIE INC.
    Inventors: Geoff G. Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • Monohydrate of azaadamantane derivatives
    Patent number: 9464078
    Abstract: The invention relates to a crystalline monohydrate of (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane dihydrogen citrate, compositions comprising such compound, and a process for preparing such compound.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: October 11, 2016
    Assignee: AbbVie Inc.
    Inventors: Shuang Chen, James J. Napier, Geoff G. Z. Zhang, Paul J. Brackemeyer
  • CRYSTALLINE FORM OF A DRUG
    Publication number: 20150266860
    Abstract: Atrasentan Hydrochloride Crystalline Form 3, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Application
    Filed: June 2, 2015
    Publication date: September 24, 2015
    Applicant: AbbVie Inc.
    Inventor: Geoff G.Z. ZHANG
  • Anti-infective agents and uses thereof
    Patent number: 9139536
    Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 22, 2015
    Assignee: AbbVie Inc.
    Inventors: Charles A. Flentge, Douglas K. Hutchinson, David A. Betebenner, David A. DeGoey, Pamela L. Donner, Warren M. Kati, Allan C. Krueger, Dachun Liu, Yaya Liu, Kenton L. Longenecker, Clarence J. Maring, Christopher E. Motter, John K. Pratt, John T. Randolph, Todd W. Rockway, Kent D. Stewart, Rolf Wagner, Shuang Chen, Yi Gao, Xiaochun Lou, Geoff G. Z. Zhang
  • NOVEL MONOHYDRATE OF AZAADAMANTANE DERIVATIVES
    Publication number: 20150239882
    Abstract: The invention relates to a crystalline monohydrate of (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane dihydrogen citrate, compositions comprising such compound, and a process for preparing such compound.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 27, 2015
    Inventors: Shuang Chen, James J. Napier, Geoff G.Z. Zhang, Paul J. Brackemeyer
  • Salt and Crystalline Forms Thereof of a Drug
    Publication number: 20150196547
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Application
    Filed: February 3, 2015
    Publication date: July 16, 2015
    Inventors: Geoff G.Z. ZHANG, Michael F. BRADLEY, David M. BARNES, Rodger HENRY
  • AZAADAMANTANE DERIVATIVES AND METHODS OF USE
    Publication number: 20150158867
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: February 17, 2015
    Publication date: June 11, 2015
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G.Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • Crystalline form of a drug
    Patent number: 9051301
    Abstract: Atrasentan Hydrochloride Crystalline Form 3, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: June 9, 2015
    Assignee: AbbVie Inc.
    Inventor: Geoff G. Z. Zhang
  • Preparation of Pyridonecarboxylic Acid Antibacterials
    Publication number: 20150094475
    Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 2, 2015
    Inventors: Anthony HAIGHT, David M. BARNES, Geoff G.Z. ZHANG
  • Azaadamantane derivatives and methods of use
    Patent number: 8987453
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: March 24, 2015
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G. Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • Anti-infective agents and uses thereof
    Patent number: 8986740
    Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: March 24, 2015
    Assignee: AbbVie Inc.
    Inventors: Pamela L. Donner, John T. Randolph, Allan C. Krueger, David A. Betebenner, Douglas K. Hutchinson, Dachun Liu, Yaya Liu, Kenton L. Longenecker, Clarence J. Maring, John K. Pratt, Todd W. Rockway, Kent D. Stewart, Rolf Wagner, Shuang Chen, Yi Gao, John E. Hengeveld, Rodger F. Henry, Xiaochun Lou, Geoff G. Z. Zhang
  • Salt and crystalline forms thereof of a drug
    Patent number: 8969569
    Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: March 3, 2015
    Assignee: AbbVie Inc.
    Inventors: Geoff G. Z. Zhang, Michael F. Bradley, David M. Barnes, Rodger Henry
  • Pharmaceutical Composition Having Improved Dissolution Profiles For Poorly Soluble Drugs
    Publication number: 20150057266
    Abstract: Pharmaceutical compositions having improved dissolution profiles for drugs therein are disclosed.
    Type: Application
    Filed: October 31, 2014
    Publication date: February 26, 2015
    Inventors: Huailiang WU, Geoff G.Z. ZHANG
  • Preparation of pyridonecarboxylic acid antibacterials
    Patent number: 8927723
    Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: January 6, 2015
    Assignee: AbbVie, Inc.
    Inventors: Anthony Haight, David M. Barnes, Geoff G. Z. Zhang
  • ABT-263 capsule
    Patent number: 8927009
    Abstract: A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: January 6, 2015
    Assignee: AbbVie Inc.
    Inventors: Ping Tong, Deliang Zhou, Geoff G. Z. Zhang, Katherine R. Heemstra, Cristina M. Fischer, Nathaniel D. Catron, Eric A. Schmitt, Yeshwant D. Sanzgiri
  • SALTS OF FENOFIBRIC ACID AND PHARMACEUTICAL FORMULATIONS THEREOF
    Publication number: 20140187561
    Abstract: In one aspect, the present invention relates to a formulation in the form of molecular dispersion comprising i) fenofibric acid, a physiologically acceptable salt or derivative thereof and optionally other active substances, ii) a binder component comprising at least one enteric binder, and optionally iii) other physiologically acceptable excipients. In a second aspect, the present invention relates to novel salts of fenofibric acid that are photostable when compared to other salts of fenofibric acid.
    Type: Application
    Filed: July 29, 2013
    Publication date: July 3, 2014
    Inventors: Russell Drew Cink, Joseph B. Paterson, Jr., Yi Gao, Geoff G.Z. Zhang, Michelle A. Long, John B. Morris, Joerg Rosenberg