Abstract: A method for identifying and handling related incidents using a machine-learning based model, includes, performing by one or more processors, operations including: clustering a sub-group of incident records from among a plurality of incident records using the machine-learning based model based on a rolling time window and a number of records in the sub-group of incident records; creating a problem record based on the clustered incident records; populating the problem record with information related to the clustered incident records; linking the clustered incident records to the problem record; providing a notification that the problem record has been created; receiving a resolution for the problem record; and updating, based on the resolution, the machine-learning based model to learn an association between extracted features of the resolution and extracted features of the clustered incident records.

Abstract: A method for improving the quality of a machine-learning based model includes generating a first query requesting a description of a change proposed to a system and an intended outcome of the change proposed; receiving a first response; generating a second query providing a risk of an incident associated with the change proposed and requesting justification of the change proposed in view of the risk; receiving a second response; generating a third query requesting an implementation plan for the change proposed; receiving a third response; generating an alert to an incident owner providing the description, intended outcome, risk, justification, and implementation plan of the change proposed; receiving a risk confirmation or rejection from the incident owner confirming or rejecting a relationship between the change proposed and the risk; and updating the machine-learning based model to learn an association between extracted features of the change and extracted features of the incident.

Abstract: The present invention relates generally to recombinant adenoviral pharmaceutical formulations. More particularly, the present invention relates to SiO2-gel-based controlled release recombinant adenoviral pharmaceutical formulations.

Abstract: An apparatus for treating a medium, the apparatus including structure for generating a flow of a working fluid in a flow path, treatment structure for subjecting the medium to treatment and a delivery device for delivering the medium to the treatment structure, the treatment structure and the delivery device being operable in response to the flow of working fluid. A refuge chamber and method utilize such apparatus.

Abstract: A method for depositing a metal containing material onto a porous substrate, the method comprises forming a seed coating on the substrate, wherein the seed coating at least partially covers the substrate, the seed coating being substantially free of precious metal and applying a metal containing material to the seed coating, wherein the surface area of the substrate is greater than 0.02 m2/cc, as determined prior to coating the substrate. Non-porous substrates may also be coated using a similar process.

Abstract: A device (1) monitors a validator (2) used by a terminal, this terminal taking the form of an Electronic Gaming Machine (EGM) (3) having a central control unit (CCU) (4). Device (1) includes a first interface (5) for connection to validator (2), and a second interface (6) for connection to CCU (4). Device (1) also includes a processor (7) for passing signals (not shown) between interface (5) and interface (6), and compiling information (not shown) in response to the passed signals. Device (1) further includes a port (8) for communicating the information to a server (9) external of EGM (3).

Abstract: A pedal assembly comprises a pair of pedals connected to a shaft which is rotated by links connected to the pedals such that the links operate in tension when the pedals are depressed. The pedals have spring loaded plungers which return them to a neutral position when there is no pressure on the pedals.

Abstract: The present invention relates to a vaccine composition comprising a carbohydrate polymer comprising mannose and flu antigen(s) (e.g. whole inactivated influenza virus) in admixture, and a method of immunising a subject comprising the step of administering the vaccine composition to a subject.

Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

Abstract: A hydromechanical variable speed transmission (1) including outer and inner differential gear trains each having a carrier carrying planet pinions meshing with two coaxial side gears, the side gears of the outer differential gear train being ring gears one of which is an input ring gear (11) and the other (52) of which rotatably drives the planet pinion carrier of the inner differential gear train, the side gears of the inner differential gear train respectively rotatably driving two coaxial output shafts which extend axially outwards through the ring gears (11, 52) of the outer differential gear train, the planet pinion carrier (14) of the outer differential gear train rotatably driving a hydraulic motor (2) which is fluidly coupled by a hydraulic circuit to rotatably drive a hydraulic pump (3) having a pump control for changing the displacement of the hydraulic pump (3) in response to rotation thereof, wherein the pump control is fixed from rotation to thereby isolate the input ring gear (11) from torque re

Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

Abstract: The present invention provides a method of immunising a subject comprising the step of administering a composition comprising an antigen and a carbohydrate polymer comprising mannose to a mucosal site of the subject, methods of use of the composition for vaccination and sterilization and use of the composition in manufacturing a medicament.

Abstract: An apparatus for treating a medium, the apparatus including structure for generating a flow of a working fluid in a flow path, treatment structure for subjecting the medium to treatment and a delivery device for delivering the medium to the treatment structure, the treatment structure and the delivery device being operable in response to the flow of working fluid. A refuge chamber and method utilize such apparatus.

Abstract: The present invention relates to a vaccine composition comprising a carbohydrate polymer comprising mannose and flu antigen(s) (e.g. whole inactivated influenza virus) in admixture, and a method of immunising a subject comprising the step of administering the vaccine composition to a subject.

Abstract: A cancer vaccine, and a composition for the ex vivo priming of dendritic cells, is disclosed which comprises a MUC1 T cell epitope-derived peptide or peptide analogue capable of provoking a cytotoxic T cell immune response. Particular MUC1 T cell epitope-derived peptides disclosed include TTAPPVHGL, STAPPVHGL, STAPPAHGL, TTAPPAHGV and SAPDTYPAL.

Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

Abstract: A clock synchronization method is described for a system including N clocks, at least three and at most N?1 of which are master candidate clocks. A start message is broadcast from the fastest master candidate clock. From each of the master candidate clocks, a response message including the local time of receipt of the start message according to the clock in question is broadcast. Using the information representing the times of receipt of the start message, the median master candidate clock is selected and becomes the master clock. The master clock determines the clock synchronisation error for each master candidate clock, using the information representing the times of receipt of the start message. If any such clock synchronisation error is excessive the master clock declassifies the clock in question as a master candidate clock and classifies another clock as a master candidate clock.

Abstract: The present invention provides a method for treating elevated serum triglycerides or hypertension via administering to a human subject with elevated serum triglycerides or hypertension an effective amount of pharmaceutical composition comprising a 5-lipoxygenase inhibitor, in an effective amount which is sufficient to reduce elevated serum triglycerides or hypertension, wherein the 5-lipoxygenase inhibitor is not NDGA or curcumin.