Abstract: A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

Abstract: A set of different metal and rope components can be used by groups or individuals to match a pre-determined pattern. A game operator can provide the individual or team with individual assembly components and a pre-determined pattern diagram. The team is then required to configure the different available components so as to match the diagram. In one embodiment of the present invention, the diagram is provided in black-and-white and the assembly components are in color. In one embodiment, a game is provided whereby a team uses trial and error to first build the assembly of pieces to match the diagram. Next, the team must plan and rehearse a strategy for quickly re-assembling the pieces to match the diagram while being timed by a clock. The process in accordance with the present invention is self-checking in that there is only one unique solution to the pre-determined assembly.

Abstract: The present invention provides a progressive fact or trivia game. In one embodiment, the present invention is implemented as a series of cards, each having a unique multiple choice question as well as a unique number or other identifying indicia placed conspicuously thereon. After each possible answer to the question, another number or identifying indicia appears referencing a separate card in the series. When a player answers a question from a given card, the number or other indicia placed beside the player's answer indicates the next card to which the player should proceed. The next card holds the next question for the player to answer. The present invention can be implemented through physical cards or electronically over a network, for example.

Abstract: The present invention provides a progressive fact or trivia game. In one embodiment, the present invention is implemented as a series of cards, each having a unique multiple choice question as well as a unique number or other identifying indicia placed conspicuously thereon. After each possible answer to the question, another number or identifying indicia appears referencing a separate card in the series. When a player answers a question from a given card, the number or other indicia placed beside the player's answer indicates the next card to which the player should proceed. The next card holds the next question for the player to answer. The present invention can be implemented through physical cards or electronically over a network, for example.

Abstract: Desirable fusion proteins can be produced in and purified from the milk of transgenic animals. The peptides are made as fusion proteins with a suitable fusion partner such as human alpha-fetoprotein. The fusion partner protein acts to promote and increase the half-life of the overall molecule as well as having therapeutic effects on its own. The fusion protein is typically produced through the use of transgenic animals and can be purified away from the now the milk or other bodily fluid of such an animal by an affinity purification method. A particular advantage of producing peptides via this route, in addition to the obvious advantages of high yield and biocompatibility, is that specific post-translational modifications, such as carboxy terminal amidation, can be performed in the mammary gland.

Abstract: A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

Abstract: A satellite position system with a plurality of satellites transmitting spread spectrum signals to a satellite position system receiver that is able to determine location using three spread spectrum signals and a polynomial surface fit to digital altitude data that approximates the altitude of the satellite position system receiver.

Abstract: A process for preparing agrochemical intermediates of formula (I), wherein W is (CH.sub.3 O).sub.2 CH.CHCO.sub.2 CH.sub.3 or CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 ; Z.sup.1 is a halogen atom; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alky, C alkoxy, acetoxy or acyl; the process comprising the steps of: (a) reacting a compound of formula (II), wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with a compound of formula ROCH.sub.3, wherein R is a metal; and, (b) reacting the product of (a) with a compound of formula (III), wherein Z.sup.1 and Z.sup.2 are halogen atoms. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (11) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (11) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen.

Abstract: A process for making a 1,2-benzisothiazolin-3-one by cycling a bisamide precursor under alkaline conditions in the presence of oxygen or an oxygen-release compound in the presence of a nitrogen, sulphur or phosphorus nucelophile.

Abstract: The trimethylsulphonium salt of N-phosphonomethylglycine is prepared by reacting N-phosphonomethylglycine, preferably in the form of a solid, with an aqueous solution of trimethylsulphonium carbonate or trimethylsulphonium bicarbonate or a mixture thereof. The trimethylsulphonium carbonate or trimethylsulphonium bicarbonate may be prepared by bubbling carbon dioxide through an aqueous solution of trimethylsulphonium hydroxide. It is possible to manufacture trimethylsulphonium carbonate or bicarbonate at one site and then transport them to a different site for local manufacture of N-phosphonomethylglycine in a relatively unsophisticated plant which produces minimal effluent.

Abstract: A process for the preparing agrochemical intermediates of formula (I): ##STR1## wherein W is (CH.sub.3 O) CH.CHCO.sub.2 CH.sub.3 or CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 ; Z.sup.1 is a halogen atom; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl; the process comprising the steps of:(a) reacting a compound of formula (II): ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with a compound of formula ROCH.sub.3, wherein R is a metal; and,(b) reacting the product of (a) with a compound of formula (III): ##STR3## wherein Z.sup.1 and Z.sup.2 are halogen atom. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen.

Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl, and processes for preparing the same.