Patents by Inventor Geoffrey L. Greene

Geoffrey L. Greene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LASOFOXIFENE TREATMENT OF AROMATASE-RESISTANT ER+ CANCER
    Publication number: 20230321035
    Abstract: The disclosure provides methods for treating estrogen receptor positive (ER+) cancer in a patient who has progressed on an aromatase inhibitor. Of particular interest are ER+ cancers that do not harbor a gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene. The provided methods involve the administration of an effective amount of lasofoxifene, a pharmaceutically acceptable salt, prodrug or functional derivative thereof.
    Type: Application
    Filed: May 30, 2023
    Publication date: October 12, 2023
    Inventors: Barry Samuel KOMM, Geoffrey L. GREENE
  • Modulators of resistant androgen receptor
    Patent number: 11739069
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: August 29, 2023
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • LASOFOXIFENE TREATMENT OF AROMATASE-RESISTANT ER+ CANCER
    Publication number: 20230149350
    Abstract: The disclosure provides methods for treating estrogen receptor positive (ER+) cancer in a patient who has progressed on an aromatase inhibitor. Of particular interest are ER+ cancers that do not harbor a gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene. The provided methods involve the administration of an effective amount of lasofoxifene, a pharmaceutically acceptable salt, prodrug or functional derivative thereof.
    Type: Application
    Filed: November 17, 2022
    Publication date: May 18, 2023
    Inventors: Barry Samuel KOMM, Geoffrey L. Greene
  • MODULATORS OF RESISTANT ANDROGEN RECEPTOR
    Publication number: 20200172504
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
    Type: Application
    Filed: October 21, 2019
    Publication date: June 4, 2020
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • Modulators of resistant androgen receptor
    Patent number: 10450294
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: October 22, 2019
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • MODULATORS OF RESISTANT ANDROGEN RECEPTOR
    Publication number: 20170320849
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
    Type: Application
    Filed: May 12, 2017
    Publication date: November 9, 2017
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • Modulators of resistant androgen receptor
    Patent number: 9650359
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 16, 2017
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • MODULATORS OF RESISTANT ANDROGEN RECEPTOR
    Publication number: 20160257666
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
    Type: Application
    Filed: May 18, 2016
    Publication date: September 8, 2016
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • Modulators of resistant androgen receptor
    Patent number: 9365542
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful in medicine, and particularly for treating any of a variety of diseases, disorders or conditions.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: June 14, 2016
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • MODULATORS OF RESISTANT ANDROGEN RECEPTOR
    Publication number: 20150274693
    Abstract: The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful in medicine, and particularly for treating any of a variety of diseases, disorders or conditions.
    Type: Application
    Filed: October 25, 2013
    Publication date: October 1, 2015
    Inventors: Minna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
  • Neutron guide
    Patent number: 5949840
    Abstract: A neutron guide in which lengths of cylindrical glass tubing have rectangular glass plates properly dimensioned to allow insertion into the cylindrical glass tubing so that a sealed geometrically precise polygonal cross-section is formed in the cylindrical glass tubing. The neutron guide provides easier alignment between adjacent sections than do the neutron guides of the prior art.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: September 7, 1999
    Assignee: The Regents of the University of California
    Inventor: Geoffrey L. Greene
  • Non-contacting electro-pneumatic servo for vibration isolation
    Patent number: 4850261
    Abstract: A sensing system for a vibration isolation table. A sensor responsive to the position of the tabletop is spaced apart from the tabletop and provides an output corresponding to the position of the tabletop. The output is modified to provide a control signal and a valve responsive to the modified signal controls the flow of air into and out of an air isolator which supports the load.
    Type: Grant
    Filed: March 7, 1988
    Date of Patent: July 25, 1989
    Assignee: Technical Manufacturing Corporation
    Inventor: Geoffrey L. Greene
  • Antibody to human progesterone receptor and diagnostic materials and methods
    Patent number: 4742000
    Abstract: Methods and procedures are described for the isolation of human progestin receptors and for the use of human progestin receptors as immunogens in producing both monoclonal and polyclonal antibodies. These antibodies are used for the detection of progestin receptors, such as the progesterone receptor both normal and cancerous tissues.
    Type: Grant
    Filed: May 2, 1986
    Date of Patent: May 3, 1988
    Assignee: University of Chicago
    Inventor: Geoffrey L. Greene
  • Non contacting electro-pneumatic servo for vibration isolation
    Patent number: 4730541
    Abstract: A sensing system for a vibration isolation table. A sensor responsive to the position of the tabletop is spaced apart from the tabletop and provides an output corresponding to the position of the tabletop. The output is modified to provide a control signal and a valve responsive to the modified signal controls the flow of air into and out of an air isolator which supports the load.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: March 15, 1988
    Assignee: Technical Manufacturing Corporation
    Inventor: Geoffrey L. Greene