Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: A system for precoating a preform for drawing optical fiber including a diameter sensor to determine a diameter of pulled optical fiber, a cooling system to cool the optical fiber once it is pulled from a furnace, a coating system to apply a coating to the optical fiber once it has cooled and an ultra-violet lamp to cure the coating.

Abstract: A system for precoating a preform for drawing optical fiber including a diameter sensor to determine a diameter of pulled optical fiber, a cooling system to cool the optical fiber once it is pulled from a furnace, a coating system to apply a coating to the optical fiber once it has cooled and an ultra-violet lamp to cure the coating.

Abstract: A system for precoating a preform for drawing optical fiber including a diameter sensor to determine a diameter of pulled optical fiber, a cooling system to cool the optical fiber once it is pulled from a furnace, a coating system to apply a coating to the optical fiber once it has cooled and an ultra-violet lamp to cure the coating.

Abstract: A system for precoating a preform for drawing optical fiber including a diameter sensor to determine a diameter of pulled optical fiber, a cooling system to cool the optical fiber once it is pulled from a furnace, a coating system to apply a coating to the optical fiber once it has cooled and an ultra-violet lamp to cure the coating.

Abstract: A system for drawing optical fiber in microgravity including a sealed housing to prevent infiltration of at least humidity and filled with a dry environment, a preform holder located within the sealed housing to hold preform material, a furnace located within the sealed housing to receive the preform material from the preform holder and to heat the preform material from which the optical fiber is pulled, a feed system to move the preform material from the preform holder to the furnace, a drawing mechanism located within the sealed housing to pull the optical fiber from the preform material within the furnace, a diameter monitor located within the sealed housing to measure a diameter of the optical fiber and a fiber collection mechanism located within the sealed housing to gather and store the optical fiber.

Abstract: One or more specific embodiments disclosed herein includes a clamp for use with downhole equipment, comprising a clamp top, which comprises a first hinged side and a first adjustable side; a clamp bottom, which comprises a second hinged side and a second adjustable side, wherein the first hinged side and the second hinged side are connected to form a clamp hinge, and further wherein the first adjustable side and the second adjustable side are adjacent to each other; a clip attached to the outer diameter of the clamp top, wherein the clip and the clamp top form a clip hinge on the outer diameter of the clamp top; and one or more rub bars attached to the outer diameter of the clamp top.

Abstract: A sensor system to provide data for use to control manufacture of an optical fiber in microgravity including a diameter sensor to monitor a diameter of a fiber drawn from a preform material, a tension sensor to monitor tension of the fiber as the fiber is pulled from the preform material to a storage device and a controller in communication with at least one of the diameter sensor and the tension sensor to evaluate sensor data to determine at least one of a speed and rate at which the fiber is pulled from the preform material.

Abstract: A system for drawing optical fiber in microgravity including a sealed housing to prevent infiltration of at least humidity and filled with a dry environment, a preform holder located within the sealed housing to hold preform material, a furnace located within the sealed housing to receive the preform material from the preform holder and to heat the preform material from which the optical fiber is pulled, a feed system to move the preform material from the preform holder to the furnace, a drawing mechanism located within the sealed housing to pull the optical fiber from the preform material within the furnace, a diameter monitor located within the sealed housing to measure a diameter of the optical fiber and a fiber collection mechanism located within the sealed housing to gather and store the optical fiber.

Abstract: The invention provides a container lid (1) comprising: a closure panel (7) comprising an inside surface and an outside surface; a container fastening portion (9); and a liner (5) comprising one or more layers, connected to the inside surface of the closure panel, wherein the liner or at least a lowermost layer of the liner is detachable from the closure panel, characterized in that said container lid comprises a resilient portion (15) located between said closure panel and said fastening portion.

Abstract: A system for controlling an ambient microgravity environment of a system for drawing optical fiber including a filter arranged to cleanse an environment from contaminants, a molecular sieve arranged in a series of at least one of meshes and baffles to dehumidify the environment, at least one of a pump and a fan to draw an environmental gas through the filter, through the molecular sieve and back in to an ambient environment and a housing in which the filter, molecular sieve and at least one of pump and fan reside.

Abstract: A preform material including a starter tip to facilitate an initial fiber draw from the preform within a furnace, wherein the tip comprises a vacuum-sealed tip to receive a plastic grip which attached to an end of a preform.

Abstract: A system for drawing optical fiber in microgravity including a sealed housing to prevent infiltration of at least humidity and filled with a dry environment, a preform holder located within the sealed housing to hold preform material, a furnace located within the sealed housing to receive the preform material from the preform holder and to heat the preform material from which the optical fiber is pulled, a feed system to move the preform material from the preform holder to the furnace, a drawing mechanism located within the sealed housing to pull the optical fiber from the preform material within the furnace, a diameter monitor located within the sealed housing to measure a diameter of the optical fiber and a fiber collection mechanism located. within the sealed housing to gather and store the optical fiber.

Abstract: An apparatus for use in a wellbore is disclosed that in one non-limiting embodiment includes a set down tool that includes a locating device configured to engage with an outer member at a selected location, a set down device configured to set down in a set down profile in the outer member when the set down device is activated, an alignment device for activating the set down device and a locking device that operates the alignment device to activate the set down device while maintaining the locating device engaged with the outer member.

Abstract: An apparatus for use in a wellbore. The apparatus includes a locating device having a locating collet configured to engage with a locating profile on a housing and disengage from the locating profile when a first pull load is applied to the locating collet, a delay device that prevents application of the first pull load on the locating collet when it is engaged with the locating profile until the delay device has been activated, and a locking device configured to prevent activation of the delay device until a second pull load less than the first is applied on the locking device for a selected period of time.

Abstract: A downhole tool for preventing flow within a portion of an oil/gas well includes a mechanism for preventing premature deployment of portions of the tool. The bottom portion of the tool is configured to insure flow through the tool from a zone below the tool after certain processes have been completed within the well.

Abstract: A cartridge contains a beverage ingredient which comprises liquid beverage ingredient and elongate particles of beverage ingredient. The cartridge comprises an inlet (45) for the introduction of an aqueous medium, an outlet (44) for a beverage produced from the beverage ingredient, and a flow path linking the inlet to the outlet. The cartridge further comprises a filter (400) located in the flow path and an aperture (128) located in the flow path downstream of the filter, the aperture arranged, in use, to generate a jet of beverage. The filter has a plurality of openings (401) sized to retain a substantial portion of the elongate particles on the upstream side of the filter to prevent blockage of the aperture. The maximum area of each opening on the upstream face of the filter is no more than ten times the area of the aperture.

Abstract: In one aspect, a device for use in a wellbore includes a tubular body; a barrier member associated with an outer surface of the tubular body configured to retain a proppant; an actuating member associated with the barrier member configured to expand the barrier member in an annular direction; and a fluid channel associated with an upper extent and a lower extent of the barrier member, configured to allow a fluid flow therethrough. In another aspect, a method for completing a multi-zone wellbore, includes deploying a barrier device at a downhole location within the wellbore; expanding a barrier member in an annulus of the wellbore; providing proppant in the annulus of the wellbore; retaining the proppant in the annulus via the barrier member; and providing a fluid flow between an upper extent and a lower extent of the barrier member.

Abstract: A cartridge containing one or more beverage ingredients and comprising an inlet for the introduction of an aqueous medium and an outlet for the beverage produced from the one or more beverage ingredients, the cartridge incorporating within a beverage flow path between the inlet and the outlet an eductor for entraining air into the beverage, the eductor comprising an aperture for producing a low pressure jet of the beverage.

Abstract: A cartridge contains a beverage ingredient which comprises liquid beverage ingredient and elongate particles of beverage ingredient. The cartridge comprises an inlet (45) for the introduction of an aqueous medium, an outlet (44) for a beverage produced from the beverage ingredient, and a flow path linking the inlet to the outlet. The cartridge further comprises a filter (400) located in the flow path and an aperture (128) located in the flow path downstream of the filter, the aperture arranged, in use, to generate a jet of beverage. The filter has a plurality of openings (401) sized to retain a substantial portion of the elongate particles on the upstream side of the filter to prevent blockage of the aperture. The maximum area of each opening on the upstream face of the filter is no more than ten times the area of the aperture.