Abstract: A method and a system of imaging a scene are disclosed. The method can include acquiring, at a frame chip acquisition rate, a plurality of frame chip images of the scene while repeatedly scanning the scene across a range of focus positions. The method can also include generating, from the plurality of frame chip images, a sequence of fused frame images. A fused frame image is generated by a focus-stacking operation on a stack of N consecutive ones of the plurality of frame chip images, at least one of the N frame chip images used in generating one of the fused frame images also being used in generating at least another one of the fused frame images. The fused frame images can be displayed at a refresh rate greater than 1/N times the frame chip acquisition rate. A method of motion artifact reduction in focus-stacking imaging is also disclosed.