Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumor cells; b) treating the tumor cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumor cells with intact heterologous bispecific and/or trisepcific antibodies showing the following properties: ?—binding to a T cell; ?—binding to at least one antigen on a tumor cell; ?—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.

Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps: a) isolating autologous tumor cells; b) treating the tumor cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumor cells with intact heterologous bispecific and/or trispecific antibodies showing the following properties: ?—binding to a T cell; ?—binding to at least one antigen on a tumor cell; ?—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.

Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumour cells; b) treating the tumour cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumour cells with intact heterologous bispecific and/or trisepcific antibodies showing the following properties: ?—binding to a T cell; ?—binding to at least one antigen on a tumour cell; ?—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.

Abstract: This invention relates to a novel form of the PHGPx protein, the sperm nuclei glutathione peroxidase (snGPx) as well as portions thereof playing a role in mammalian spermatogenesis, and to the nucleic acids encoding the same. The invention further relates to vectors containing said nucleic acid and to host cells transformed by these vectors. Furthermore the invention comprises antibodies specific for the above proteins/peptides as well as the use of the proteins/peptides in the diagnosis or therapy of male infertility.

Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of:

Abstract: The invention is directed to a method for the preparation of a conditionally immortalized immortalization-helper cell (fuseme), the fusemes generated by said method, hybridoma cells prepared using said fusemes as well as a method for immortalization of mammalian cells using said fuseme cells. Further, the invention relates to the generation of T cells directed agaist tumor cells using a fuseme cell.

Abstract: The invention relates to a DNA construct and to a method of detecting tumor promoters by employing this DNA construct.It is an object of the invention to make available an easily implemented quantitative detection method for tumor promoters.This is accomplished by a DNA construct including at least one reporter gene and a control region for the activation of a particularly strongly induced gene of the Epstein-Barr virus (EBV), and by the action of the substance to be examined on EBV-containing cells that contain the DNA construct, whereupon the resulting quantity of reporter gene product is quantitatively determined.