Patents by Inventor George A. Calin

George A. Calin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486912
    Abstract: Described herein is a method of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486913
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • Compositions and methods for the diagnosis and therapy of BCL2-associated cancers
    Patent number: 8481505
    Abstract: The invention provides methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. The invention also encompasses methods for determining the efficacy of a cancer therapy in a subject and methods for inducing apoptosis of a cell.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: July 9, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
    Patent number: 8389210
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: March 5, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8354224
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: January 15, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20120329053
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 27, 2012
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20120329859
    Abstract: Described herein is a method of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 27, 2012
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20120322859
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • Diagnositic Methods of Tumor Susceptibility With Nucleotide Polymorphisms Inside MicroRNA Target Sites
    Publication number: 20120322069
    Abstract: Methods of diagnosing tumor susceptibility or cancer including the step of determining whether a patient has one or more SNP-miRNA expression pattern combinations described herein. Each SNP-miRNA expression pattern combination is supported by data that shows that the SNP is associated with tumor susceptibility because of its ability to affect miRNA binding sites and/or miRNA:mRNA gene regulation.
    Type: Application
    Filed: February 23, 2011
    Publication date: December 20, 2012
    Applicants: The Ohio State Unversity, Board of Regents, The University of Texas System
    Inventors: Milena Nicoloso, George Calin, Hao Sun, Ramana Davuluri
  • MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CLL) and Uses Thereof
    Publication number: 20120283310
    Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of leukemia associated diseases are disclosed.
    Type: Application
    Filed: June 28, 2012
    Publication date: November 8, 2012
    Inventors: Carlo M. Croce, George A. Calin
  • Methods for Diagnosing Lung Cancer Using MicroRNA Signatures
    Publication number: 20120214701
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Prostate Cancer Using MicroRNA Signatures
    Publication number: 20120214702
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Breast Cancer Using MicroRNAs
    Publication number: 20120214693
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 28, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Breast Cancer Using miR-21, miR-125-1, miR-125b-2 and miR-145
    Publication number: 20120214691
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 27, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Stomach Cancer Using MicroRNA Signatures
    Publication number: 20120214703
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Breast and Lung Cancer Using miR-210 and miR-213
    Publication number: 20120214689
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 27, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Pancreatic Cancer Using MicroRNAs
    Publication number: 20120214696
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 28, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Colon Cancer Using MicroRNA Signatures
    Publication number: 20120214700
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Breast Cancer Using MicroRNA Signatures
    Publication number: 20120214699
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Breast, Colon, Lung, Pancreatic and Prostate Cancer Using miR-21 and miR-17-5p
    Publication number: 20120214688
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 27, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia