Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.

Abstract: Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1-like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1. Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1 fragment in which the amino acid residue in the base amino acid sequence corresponding to the P?1 residue of GLP-1 is an amino acid analog having a tetrasubstituted C? carbon; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have the properties indicated above. The invention also includes methods of treatment where these analogs are administered.

Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.

Abstract: The present invention generally provides polypeptide analogues of GLP-‘(9-34) and GLP-1 (9-36) that have increased in vivo half-lives resulting from reduced susceptibility to proteolytic enzymes. Other aspects of the invention relate to methods of using the polypeptide analogues described herein for treating cardiac dysfunction and other heart-related maladies. Yet another aspect of the present invention relates lo formulations comprising the polypeptide analogues described herein.

Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.

Abstract: Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1-like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1. Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1 fragment in which the amino acid residue in the base amino acid sequence corresponding to the P?1 residue of GLP-1 is an amino acid analog having a tetrasubstituted C? carbon; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have the properties indicated above. The invention also includes methods of treatment where these analogs are administered.

Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.

Abstract: Small, low cost, notch antennas are provided that can be internally incorporated into the existing structure of wireless communicators, and that are functional in a variety of orientations of the wireless communicator. The notch antenna is preferably formed in the ground plane conductor of a printed circuit board (PCB) that has RF circuitry thereon for receiving and transmitting RF signals. The notch preferably has a configuration that results in electromagnetic waves having a substantially omnidirectional radiation pattern being radiated from the notch when RF signals are applied to the notch. Integrating the antenna function into the same printed circuit board (PCB) on which the transmitter and/or receiver functions are also located eliminates the need for an additional antenna component. However, if necessary, a notch antenna surface component is also provided.

Abstract: In an antenna structure including multiple antennas, a first antenna can include a conductive patch and a second antenna can be adjacent the conductive patch. More particularly, the second antenna can define a central axis wherein the central axis is orthogonal with respect to the first antenna and wherein the central axis intersects a central portion of the conductive patch. Alternately or in addition, a first antenna can include a conductive patch with an opening through the conductive patch, and a second antenna can be adjacent the conductive patch wherein a feedline for the second antenna extends through the opening through the conductive patch.

Abstract: Inverted-F antennas that resonate within first and second frequency bands for use within communications devices, such as radiotelephones, are provided. A first planar conductive element has an elongated, rectangular configuration that extends along a first direction. The first planar conductive element has opposite first and second sides and an elongated edge. One or more additional planar conductive elements are electrically connected to the elongated edge of the first planar conductive element. Each additional planar conductive element has an elongated, rectangular configuration that extends along a second direction that is substantially parallel with the first direction. Each additional planar conductive element is maintained in adjacent, co-planar, spaced-apart relationship with the first planar conductive element.

Abstract: Antenna systems for transmitting electrical signals are provided which include a quadrifilar helix antenna. A first antenna feed is coupled to the quadrifilar helix antenna for exciting the radiating elements in phase quadrature. A second antenna feed is also coupled to the quadrifilar helix antenna for exciting the radiating elements in-phase. These antenna systems may be operated in either a helical radiation mode, where the antenna may be designed to radiate as a resonant quadrifilar helix antenna, or in a monopole radiation mode, where the antenna acts as the equivalent of a large monopole antenna. Additionally, the antenna systems may further include means for matching the impedance of the quadrifilar helix antenna to the impedance of either or both of the antenna feeds.

Abstract: An oil well pump drive including a drive unit that is hydraulically actuated by a double-acting hydraulic cylinder to reciprocate vertically. An endless chain is entrained over vertically spaced sprockets carried by the unit, with one flight of the chain anchored against vertical movement and the other flight is secured to the pump polish rod so that the vertical motion imparted to the polish rod is double that hydraulically imparted to the drive unit. The polish rod load on the chain is opposed by a counterweight connected thereto by a chain extending over an elevated pulley. The output of the hydraulic pump supplying the hydraulic cylinder is cam controlled so that the motion of the drive unit is smoothly decelerated and accelerated as the unit approaches and moves from the upper and lower limits of its movement.