Patents by Inventor George B. Stefano

George B. Stefano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220110965
    Abstract: This document provides methods and materials for treating diabetes and/or liver steatosis. For example, methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of diabetes or liver steatosis are provided.
    Type: Application
    Filed: November 1, 2021
    Publication date: April 14, 2022
    Inventors: George B. STEFANO, Richard KREAM, Kirk J. MANTIONE
  • Patent number: 11253538
    Abstract: This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: February 22, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: George B. Stefano, Richard M. Kream, Kirk J. Mantione
  • Patent number: 11160825
    Abstract: This document provides methods and materials for treating diabetes and/or liver steatosis. For example, methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of diabetes or liver steatosis are provided. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to treat fatty liver disease.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: November 2, 2021
    Assignee: Research Foundation of the State University of New York
    Inventors: George B. Stefano, Richard Kream, Kirk J Mantione
  • Publication number: 20200268787
    Abstract: This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 27, 2020
    Inventors: George B. Stefano, Richard M. Kream, Kirk J. Mantione
  • Patent number: 10639322
    Abstract: This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: May 5, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: George B. Stefano, Richard M. Kream, Kirk J. Mantione
  • Publication number: 20190151357
    Abstract: This document provides methods and materials for producing and/or using mitochondrial preparations. For example, methods and materials for using xyloglucan (e.g., xyloglucan material obtained from potato) to produce improved mitochondrial preparations are provided. In addition, methods and materials for administering mitochondrial preparations to cells to improve cellular function and/or to reduce a symptom of a disease or disorder are provided.
    Type: Application
    Filed: September 11, 2017
    Publication date: May 23, 2019
    Inventors: Richard M. Kream, George B. Stefano
  • Publication number: 20190076461
    Abstract: This document provides materials and methods for treating hypoxic conditions (e.g., tissue ischemia). Compositions containing a potato polysaccharide preparation and organic selenium can be used to increase or maintain mitochondrial nitric oxide formation. Compositions provided herein can also contain inorganic nitrate.
    Type: Application
    Filed: March 13, 2017
    Publication date: March 14, 2019
    Inventors: Richard M. Kream, George B. Stefano
  • Publication number: 20180078599
    Abstract: This document provides methods and materials for treating cancer. For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce the number of cancer cells in a mammal. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to reduce the number of cancer cells in a mammal, wherein the cancer cells express a KRAS polypeptide.
    Type: Application
    Filed: March 25, 2016
    Publication date: March 22, 2018
    Inventors: George B. Stefano, Richard M. Kream, Kirk J. Mantione
  • Publication number: 20180078575
    Abstract: This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.
    Type: Application
    Filed: March 25, 2016
    Publication date: March 22, 2018
    Inventors: George B. Stefano, Richard M. Kream, Kirk J. Mantione
  • Publication number: 20170232033
    Abstract: The document provides nutritional supplement compositions. For example, nutritional supplement compositions containing a potato polysaccharide preparation, methods for obtaining potato polysaccharide preparations, methods for making nutritional supplement compositions containing a potato polysaccharide preparation, and methods for increasing or decreasing expression of polypeptides involved with mitochondria activity or function are provided.
    Type: Application
    Filed: March 29, 2017
    Publication date: August 17, 2017
    Applicant: The Research Foundation for The State University of New York
    Inventors: George B. Stefano, Richard Kream, Kirk J. Mantione
  • Patent number: 9474749
    Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: October 25, 2016
    Assignee: The Research Foundation for the State University of New York
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • Publication number: 20160243152
    Abstract: This document provides methods and materials for treating diabetes and/or liver steatosis. For example, methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of diabetes or liver steatosis are provided. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to treat fatty liver disease.
    Type: Application
    Filed: August 29, 2014
    Publication date: August 25, 2016
    Applicant: The Research Foundation for The State University of New York
    Inventors: George B. STEFANO, Richard KREAM, Kirk J. MANTIONE
  • Publication number: 20150065451
    Abstract: The document provides nutritional supplement compositions. For example, nutritional supplement compositions containing a potato polysaccharide preparation, methods for obtaining potato polysaccharide preparations, methods for making nutritional supplement compositions containing a potato polysaccharide preparation, and methods for increasing or decreasing expression of polypeptides involved with mitochondria activity or function are provided.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 5, 2015
    Inventors: George B. Stefano, Richard Kream, Kirk J. Mantione
  • Publication number: 20140348953
    Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.
    Type: Application
    Filed: August 15, 2014
    Publication date: November 27, 2014
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • Patent number: 8865696
    Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: October 21, 2014
    Assignee: The Research Foundation for the State University of New York
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • Publication number: 20140128420
    Abstract: Dietary supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6?-glucuronide are provided.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: The Research Foundation of State University of New York
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • Publication number: 20130309326
    Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.
    Type: Application
    Filed: June 21, 2013
    Publication date: November 21, 2013
    Applicant: The Research Foundation of State University of New York
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • Publication number: 20130261146
    Abstract: A pharmaceutical composition for stimulating nitric oxide production in mammalian cells, the pharmaceutical composition including at least one compound selected from a group consisting of: 2,3-dihydroxypropyl oleate; bis(m-phenoxyphenyl) ether; 6-acetyl-5,6,6a,7-tetrahydro-4H-dibezo(de,g)quinoline; and (+)-N-(p-(2-methylbutoxy)benzylidene)-4-(2-methylbutyl)aniline.
    Type: Application
    Filed: December 9, 2010
    Publication date: October 3, 2013
    Applicant: The Research Foundation of State University of New York
    Inventors: George B. Stefano, Wei Zhu, Kirk Mantione, Richard M. Kream
  • Patent number: 8481559
    Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 9, 2013
    Assignee: The Research Foundation of State University of New York
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • Patent number: 7959951
    Abstract: The invention relates to nitric oxide (NO) stimulating extracts from various plants. Such extracts contain compounds known as healthin I and healthin II. Specifically, the invention provides partially purified plant extracts that have NO stimulating activity, methods of isolating and partially purifying such extracts from plant materials. In addition, the invention provides methods and materials for treating diseases and conditions that require modification of cellular levels of NO, for example, diseases and conditions involving inflammation.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: June 14, 2011
    Assignee: The Research Foundation at State University of New York
    Inventors: George B. Stefano, Wei Zhu, Kirk Mantione