Patents by Inventor George Badescu

George Badescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DRUG-PROTEIN CONJUGATES
    Publication number: 20220062436
    Abstract: Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present.
    Type: Application
    Filed: September 17, 2021
    Publication date: March 3, 2022
    Applicant: ABZENA (UK) LIMITED
    Inventors: John BURT, Antony GODWIN, Mark FRIGERIO, George BADESCU
  • Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG
    Patent number: 10835616
    Abstract: The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: November 17, 2020
    Assignee: POLYTHERICS LIMITED
    Inventors: Antony Godwin, George Badescu, Matthew Bird, Penny Bryant, David Morris, Mark Frigerio
  • Process For The Conjugation Of A Peptide Or Protein With A Reagent Comprising A Leaving Group Including A Portion Of PEG
    Publication number: 20170304461
    Abstract: The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
    Type: Application
    Filed: October 8, 2015
    Publication date: October 26, 2017
    Applicant: POLYTHERICS LIMITED
    Inventors: Antony Godwin, George Badescu, Matthew Bird, Penny Bryant, David Morris, Mark Frigerio
  • DRUG-PROTEIN CONJUGATES
    Publication number: 20150290342
    Abstract: Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 15, 2015
    Inventors: John Burt, Antony Godwin, Mark Frigerio, George Badescu
  • DRUG-PROTEIN CONJUGATES
    Publication number: 20150283259
    Abstract: Specific conjugates containing maytansines and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 8, 2015
    Applicant: POLYTHERICS LIMITED
    Inventors: John Burt, Antony Godwin, Mark Frigerio, George Badescu
  • NOVEL PROCESS FOR PREPARATION OF ANTIBODY CONJUGATES AND NOVEL ANTIBODY CONJUGATES
    Publication number: 20150125473
    Abstract: The present invention concerns a process for the preparation of an antibody conjugate comprising the step of reacting an engineered antibody having a single inter-heavy chain disulfide bond with a conjugating reagent that forms a bridge between the two cysteine residues derived from the disulfide bond.
    Type: Application
    Filed: June 19, 2013
    Publication date: May 7, 2015
    Inventors: John Burt, Antony Godwin, George Badescu