Abstract: Targeted liposomes containing chemotherapeutic compounds of Formula (I) are provided for treating hematological cancers. The targeted liposomes can be targeted to cancer cells (e.g., malignant B cells) by attachment to an antibody or antibody fragment of a suitable cell surface antigen, e.g., CD22. The targeted liposomes have higher IC50s for cells not having the cell surface antigen as compared to similar non-targeted liposomes. Also provided are methods of preparing the targeted liposomes.

Abstract: Provided are methods for inhibiting undesirable proliferation of a tumor cell or a tumor in a subject including administering to the subject a composition that includes an effective amount of an active agent, wherein the active agent is entrapped by one or more liposomes, the active agent has activity in inhibiting undesirable proliferation of the tumor cell or the tumor, and the one or more liposomes include one or more targeting agents that preferentially or specifically bind to a binding molecule expressed by the tumor cell or the tumor, present on the tumor cell or the tumor, present in the tumor cell or the tumor, or combinations thereof. Also provided are compositions for treating tumors, particularly gliomas, in a subject in need thereof.

Abstract: An adjustable flow rate nozzle for atomizing liquids comprises a tubular-like body for conducting a liquid under pressure having a discharge end terminating in a single plane surface, a structured device having a single plane surface which is attached with its plane surface contiguous with the plane surface of the tubular-like conduit and a slit-like aperature formed between the single plane surfaces of the tubular-like conduit and the structured device. The size of the slit-like aperture and thus the atomized flow rate is adjustable by securing structured devices to cooperate with the discharge end of the tubular-like body. The tubular body contains a main feed cavity of relatively large circular cross section and at least one corona cavity which is elongated outwardly from the main feed cavity. The corona cavity includes a pair of spaced sidewalls extending outwardly from the main feed cavity and an arcuate end wall joining the spaced side walls remote from the main feed cavity.