Abstract: Provided herein are devices, systems, and methods for introducing a nebulized medication into breathing gas for respiratory therapy. An apparatus includes a reservoir to contain a volume of medication, a vibrating mesh disposed at a reservoir outlet of the reservoir to receive a flow of the medication from the reservoir and output a flow of nebulized medication, a mixing chamber having a gas inlet to receive a flow of breathing gas from a gas source, and a nebulizer inlet to receive the flow of nebulized medication from the vibrating mesh, where the vibrating mesh is disposed between the nebulizer inlet and the reservoir outlet. The apparatus can include a pressure tap tube or other implement in fluid communication with the mixing chamber and the reservoir to selectively equalize pressure between the mixing chamber and a headspace in the reservoir above the volume of medication.