Patents by Inventor George E. Mark, III

George E. Mark, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing the immunogenicity of antibody variable domains
    Patent number: 6797492
    Abstract: A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: September 28, 2004
    Assignees: Merck & Co., Inc., United States of America
    Inventors: Bruce L. Daugherty, George E. Mark, III, Eduardo A. Padlan
  • Formulations of recombinant papillomavirus vaccines
    Patent number: 6280740
    Abstract: Vaccine formulations comprising recombinant early (E) and late (L) proteins of papillomavirus and oxidized mannan as well as methods of making and using the formulations are provided.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: August 28, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Sunil K. Gupta, George E. Mark, III
  • Synthetic HPV11 virus-like particles
    Patent number: 5795754
    Abstract: The present invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: August 18, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Steven Ludmerer, Gregory F. Hollis, Diana Benincasa, George E. Mark, III
  • Synthetic HPV11 virus-like particles
    Patent number: 5738853
    Abstract: The present invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles. The synthetic virus-like particles are generated from constructs designated as HPV6:4; HPV6:5; HPV6:2; HPV6:4.DELTA.132; and HPV6:4,S131G.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: April 14, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Steven Ludmerer, George E. Mark, III, Diana Benincasa