Abstract: The invention relates to biomarkers, and to novel biological markers for diagnosing cancer. In particular, the invention relates to the use of these compounds as diagnostic and prognostic markers in assays for detecting cancer, such as oesophagogastric cancer, and corresponding methods of detection. The invention also relates to methods of determining the efficacy of treating these diseases with a therapeutic agent. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials.

Abstract: An advanced food storing, dispensing, and packaging system, including the use of computing and communications technology to both monitor and improve quality of food. The storing and dispensing system can also integrate with better packaging. Such a system and technology is used to create a better way to acquire and control food quality, whether delivered or not, raw or cooked, that is fresher when monitored, whether it waits to be delivered for immediate consumption or is acquired raw or in bulk and stored in a home pantry. This technology can be further leveraged to enable patrons to access and transact a food purchase without waiting in a checkout line including food that is not required to be specially packaged in order to be recognized by video analytics.

Abstract: The invention relates to a method for diagnosing a subject suffering from cancer, or a pre-disposition thereto. The method comprises detecting, in a bodily sample from a test subject, the concentration of a signature compound resulting from the metabolism of at least one sugar, and/or at least one amino acid or a precursor thereof, and/or at least one polyol present in a composition previously administered to the subject. The sugar is present in the composition at a concentration of more than 20,000 mg/100 ml, the amino acid or a precursor thereof is present in the composition at a concentration of at least 500 mg/ml, and the polyol is present in the composition at a concentration of more than 25,000 mg/100 ml. The method further comprises comparing this concentration with a reference for the concentration of the signature compound in an individual who does not suffer from cancer.

Abstract: The disclosure provides a thermal desorption (TD) tube sampler. The sampler comprises a first connector configured to reversibly connect to a TD tube containing a sample, and a second connector configured to couple to a direct injection mass spectrometer. The TD tube sampler is configured to desorb a sample in a TD tube connected thereto, and feed the desorbed sample from the TD tube to a direct injection mass spectrometer such that the desorbed sample does not pass through a cold trap.

Abstract: The invention relates to a method for diagnosing or for providing a prognosis of a subject suffering from oesophagogastric cancer, or a pre-disposition thereto. The method comprises analysing, in an endoluminal sample obtained from a test subject, the level of at least one biomarker compound selected from the group consisting of: acetone, acetic acid, butyric acid, pentanoic acid and hexanoic acid. The method further comprises comparing this level with a reference for the level of the at least one biomarker compound in an individual who does not suffer from oesophagogasatric cancer. In particular, an increase in the concentration of the at least one biomarker compound, in the endoluminal sample from the test subject, compared to the reference, suggests that the subject is suffering from oesophagogastric cancer, or has a pre-disposition thereto, or provides a negative prognosis of the subject's condition.

Abstract: The invention relates to the detection of biomarkers, and methods, compositions and kits for the detection of such biological markers for diagnosing various conditions, such as cancer. In particular, the invention relates to the detection of compounds as diagnostic and prognostic markers for detecting cancer, such as oesophago-gastric cancer.

Abstract: The disclosure provides a thermal desorption (TD) tube sampler. The sampler comprises a first connector configured to reversibly connect to a TD tube containing a sample, and a second connector configured to couple to a direct injection mass spectrometer. The TD tube sampler is configured to desorb a sample in a TD tube connected thereto, and feed the desorbed sample from the TD tube to a direct injection mass spectrometer such that the desorbed sample does not pass through a cold trap.

Abstract: The invention relates to biomarkers, and to novel biological markers for diagnosing various conditions, such as cancer. In particular, the invention relates to the use of these compounds as diagnostic and prognostic markers in assays for detecting cancer, such as pancreatic cancer and/or colorectal cancer, and corresponding methods of detection. The invention also relates to methods of determining the efficacy of treating these diseases with a therapeutic agent, and apparatus for carrying out the assays and methods. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials.

Abstract: A gearbox assembly for a gas turbine engine used in an aircraft having passive lubrication capabilities during wind milling includes a gearbox housing, a gear train assembly housed within the gearbox housing, a lubricant in the gearbox housing for lubricating the gear train assembly, and a first scavenge port formed in the gearbox housing. The first scavenge port is changeable between an open position and a closed position. Further, the first scavenge port remains in the open position during normal operation of the gas turbine engine to allow the lubricant to drain from the gearbox housing. Upon occurrence of a loss of lubricant pressure in the gearbox assembly, the first scavenge port is changed to the closed position to trap at least a portion of the lubricant in the gearbox housing. Thus, the trapped lubricant provides passive lubrication to the gear train assembly during the loss of lubricant pressure.

Abstract: A gearbox assembly for a gas turbine engine used in an aircraft having passive lubrication capabilities during wind milling includes a gearbox housing, a gear train assembly housed within the gearbox housing, a lubricant in the gearbox housing for lubricating the gear train assembly, and a first scavenge port formed in the gearbox housing. The first scavenge port is changeable between an open position and a closed position. Further, the first scavenge port remains in the open position during normal operation of the gas turbine engine to allow the lubricant to drain from the gearbox housing. Upon occurrence of a loss of lubricant pressure in the gearbox assembly, the first scavenge port is changed to the closed position to trap at least a portion of the lubricant in the gearbox housing. Thus, the trapped lubricant provides passive lubrication to the gear train assembly during the loss of lubricant pressure.

Abstract: A method of attaining virologic suppression in a heavily treatment-experienced (HTE) individual infected with the HIV-1 virus involves administering to the individual a treatment regimen comprising the drug fostemsavir together with an optimized background therapy (OBT). This treatment regimen should maintain virologic suppression to a plasma HIV-1 RNA level of less than 200 copies (c)/mL for an extended period.

Abstract: Adenocarcinoma antigenic determinants, methods for their production and use, and broadly-specific human monoclonal antibodies reactive to the epitopes. These epitopes, which can be physically recapitulated, are conserved across a range of adenocarcinomas and are capable of eliciting an immune response in humans.

Abstract: Embodiments of a bearing are provided herein. In one embodiment a bearing may include a bearing assembly having an inner race and an outer race; a plurality of rolling elements disposed between the inner race and the outer race, wherein at least one of the inner race, the outer race, and the plurality of rolling elements is at least partially fabricated from an AlMgB14 containing ceramic matrix composite.

Abstract: Embodiments of a bearing are provided herein. In one embodiment a bearing may include a bearing assembly having an inner race and an outer race; a plurality of rolling elements disposed between the inner race and the outer race, wherein at least one of the inner race, the outer race, and the plurality of rolling elements is at least partially fabricated from an AlMgB14 containing ceramic matrix composite.

Abstract: The present invention provides novel compositions and methods that can be used for determining the susceptibility of virus to an attachment inhibitor. The present invention also provides methods for predicting whether an infected individual will respond to treatment with an attachment inhibitor, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects.

Abstract: A system for monitoring and/or controlling tissue modification during an electrosurgical procedure includes an electrosurgical apparatus connected to an electrosurgical generator and configured to grasp tissue therebetween via a pair of jaw members. The system also includes an optical system having an optical source that directs light through tissue. One or more optical detectors analyze the light transmitted through and reflected back from the tissue and a processor utilizes this information to control the delivery of electrosurgical energy from the electrosurgical generator to the tissue.

Abstract: A journal bearing for use in an epicyclical gearbox including a journal pin, a journal bearing body into which the journal pin is disposed and at least one lubricating fluid inlet. The lubricating fluid inlet is configured to provide for an input of a lubricating fluid in a loaded arc portion proximate at least one high pressure point exerted upon the journal bearing body during a high pressure event, thereby permitting a free flow of a lubricating fluid there between the journal pin and the journal bearing body during the high pressure event. In an embodiment, the journal pin is configured to mimic the shape of the journal bearing body at least at a high pressure point exerted upon the journal bearing body during a high pressure event. An epicyclical gearbox including the journal bearing and method of facilitating a hydrodynamic oil flow in the planet gear journal bearing.

Abstract: A journal bearing for use in an epicyclical gearbox including a non-circular shaped journal pin and a journal bearing body into which the non-circular shaped journal pin is disposed. The non-circular shaped journal pin configured to mimic the shape of the non-cylindrical shaped journal bearing body at least at a high pressure point exerted upon the non-cylindrical shaped journal bearing body during a high pressure event, thereby permitting a free flow of a lubricating fluid there between the non-circular shaped journal pin and the journal bearing body during the high pressure event. An epicyclical gearbox including the journal bearing and method of facilitating a hydrodynamic oil flow in the planet gear journal bearing.

Abstract: A journal bearing for use in an epicyclical gearbox including a non-circular shaped journal pin and a journal bearing body into which the non-circular shaped journal pin is disposed. The non-circular shaped journal pin configured to mimic the shape of the non-cylindrical shaped journal bearing body at least at a high pressure point exerted upon the non-cylindrical shaped journal bearing body during a high pressure event, thereby permitting a free flow of a lubricating fluid there between the non-circular shaped journal pin and the journal bearing body during the high pressure event. An epicyclical gearbox including the journal bearing and method of facilitating a hydrodynamic oil flow in the planet gear journal bearing.

Abstract: A plurality of connecting elements projects from a body's surface. A plurality of indents is defined in the body's surface. Each stem element includes first and second stalks projecting orthogonally from the surface. The first stub includes a pyramidical cap section and at least one generally planar wall. The second stalk is generally parallel to the first stub and spaced apart from the at least one wall, defining a gap therebetween. The second stalk includes a stem projecting from the surface. A lip section extends from a distal end of the stem and protrudes outwardly relative to the stem. An engagement section extends from the lip section. A free end of the engagement section defines a distal end of the second stalk. An outer surface of the engagement section defines a first gradient tapering from the lip section to the distal end of the second stalk.