Patents by Inventor George J. Broze, Jr.
George J. Broze, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7060805Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.Type: GrantFiled: July 9, 2004Date of Patent: June 13, 2006Assignees: Pfizer Inc., Washington UniversityInventors: Tze Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 6841534Abstract: The disclosure describes the purification and isolation of a novel human protein Z-dependent protease inhibitor (ZPI) from plasma characterized as having a molecular weight of about 72 kDa, being a single chain protein with an N-terminal amino acid sequence of LAPSPQSPETPA, and which produces a rapid inhibition of factor Xa in the presence of human protein Z (PZ), calcium ions and cephalin. The disclosure further describes the isolation and cloning of the ZPI cDNA from a human cDNA library. The ZPI cDNA is 2.44 kb in length and has an open reading frame that encodes the 423 residue mature ZPI protein and a 21 residue signal peptide. PZ, ZPI and the combination of PZ and ZPI are used to inhibit blood coagulation.Type: GrantFiled: January 10, 2002Date of Patent: January 11, 2005Assignee: Washington UniversityInventor: George J. Broze, Jr.
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Patent number: 6806360Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.Type: GrantFiled: March 4, 2003Date of Patent: October 19, 2004Assignee: G.D. Searle & Co.Inventors: Tze Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 6534276Abstract: Molecules, such as antibodies, with binding specificity for Tissue factor Inhibitor (TFI) or for polypeptides comprising one or more Kunitz domains of TFI can be used in methods to detect TFI or polypeptides containing a Kunitz domain of TFI in biological fluids. Either direct or indirect detection methods can be carried out.Type: GrantFiled: July 28, 2000Date of Patent: March 18, 2003Assignee: G. D. Searle & CompanyInventors: Tze Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 6369031Abstract: The disclosure describes the purification and isolation of a novel human protein Z-dependent protease inhibitor (ZPI) from plasma characterized as having a molecular weight of about 72 kDa, being a single chain protein with an N-terminal amino acid sequence of LAPSPQSPETPA, and which produces a rapid inhibition of factor Xa in the presence of human protein Z (PZ), calcium ions and cephalin. The disclosure further describes the isolation and cloning of the ZPI cDNA from a human cDNA library. The ZPI cDNA is 2.44 kb in length and has an open reading frame that encodes the 423 residue mature ZPI protein and a 21 residue signal peptide. PZ, ZPI and the combination of PZ and ZPI are used to inhibit blood coagulation.Type: GrantFiled: October 25, 2000Date of Patent: April 9, 2002Assignee: Washington UniversityInventor: George J. Broze, Jr.
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Patent number: 6271367Abstract: The disclosure describes the purification and isolation of a novel human protein Z-dependent protease inhibitor (ZPI) from plasma characterized as having a molecular weight of about 72 kDa, being a single chain protein with an N-terminal amino acid sequence of LAPSPQSPETPA, and which produces a rapid inhibition of factor Xa in the presence of human protein Z (PZ), calcium ions and cephalin. The disclosure further describes the isolation and cloning of the ZPI cDNA from a human cDNA library. The ZPI cDNA is 2.44 kb in length and has an open reading frame that encodes the 423 residue mature ZPI protein and a 21 residue signal peptide. PZ, ZPI and the combination of PZ and ZPI are used to inhibit blood coagulation.Type: GrantFiled: October 25, 2000Date of Patent: August 7, 2001Assignee: Washington UniversityInventor: George J. Broze, Jr.
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Patent number: 6265378Abstract: The disclosure describes the purification and isolation of a novel human protein Z-dependent protease inhibitor (ZPI) from plasma characterized as having a molecular weight of about 72 kDa, being a single chain protein with an N-terminal amino acid sequence of LAPSPQSPETPA, and which produces a rapid inhibition of factor Xa in the presence of human protein Z (PZ), calcium ions and cephalin. The disclosure further describes the isolation and cloning of the ZPI cDNA from a human cDNA library. The ZPI cDNA is 2.44 kb in length and has an open reading frame that encodes the 423 residue mature ZPI protein and a 21 residue signal peptide. PZ, ZPI and the combination of PZ and ZPI are used to inhibit blood coagulation.Type: GrantFiled: October 25, 2000Date of Patent: July 24, 2001Assignee: Washington, UniversityInventor: George J. Broze, Jr.
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Patent number: 6245741Abstract: The disclosure describes the purification and isolation of a novel human protein Z-dependent protease inhibitor (ZPI) from plasma characterized as having a molecular weight of about 72 kDa, being a single chain protein with an N-terminal amino acid sequence of LAPSPQSPETPA, and which produces a rapid inhibition of factor Xa in the presence of human protein Z (PZ), calcium ions and cephalin. The disclosure further describes the isolation and cloning of the ZPI cDNA from a human cDNA library. The ZPI cDNA is 2.44 kb in length and has an open reading frame that encodes the 423 residue mature ZPI protein and a 21 residue signal peptide. PZ, ZPI and the combination of PZ and ZPI are used to inhibit blood coagulation.Type: GrantFiled: March 17, 1999Date of Patent: June 12, 2001Assignee: Washington UniversityInventor: George J. Broze, Jr.
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Patent number: 6171587Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined. Antibodies having a binding region specific to human tissue factor inhibitor are disclosed.Type: GrantFiled: April 3, 1998Date of Patent: January 9, 2001Assignee: G. D. Searle and CompanyInventors: Tze Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 5849875Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.Type: GrantFiled: June 5, 1995Date of Patent: December 15, 1998Assignee: G. D. Searle & Co.Inventors: Tze-Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 5773251Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.Type: GrantFiled: June 5, 1995Date of Patent: June 30, 1998Assignee: G.D. Searle & Co.Inventors: Tze-Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 5466783Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.Type: GrantFiled: July 15, 1993Date of Patent: November 14, 1995Assignees: Monsanto Company, Washington UniversityInventors: Tze-Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
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Patent number: 5106833Abstract: Novel blood coagulation inhibitors are disclosed which are peptide fragments comprising (A) Kunitz-type domain two of lipoprotein-associated coagulation inhibitor which inhibits Factor Xa production and (B) Kunitz-type domains one and two of lipoprotein-associated coagulation inhibitor which inhibits Factor VIIa/TF enzymatic complex formation.Type: GrantFiled: January 26, 1989Date of Patent: April 21, 1992Assignee: Washington UniversityInventors: George J. Broze, Jr., Thomas J. Girard
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Patent number: 4966852Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.Type: GrantFiled: November 23, 1987Date of Patent: October 30, 1990Assignees: Monsanto Company, Washington UniversityInventors: Tze-Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.