Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

Abstract: This disclosure relates to the design of E. coli mutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, and uses thereof.

Abstract: This invention relates to compositions that include a polypeptide derived from E. coli or a fragment thereof; and modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof, and methods of use thereof.

Abstract: A novel graphical interface and input method is provided. In certain implementations, a touch screen interface is provided with a plurality of icons that each represent seats around a table in a restaurant. Each icon is associated with a unique account. Accounts can be easily merged and split by using touch and swipe interfaces with the icons.

Abstract: A novel graphical interface and input method is provided. In certain implementations, a touch screen interface is provided with a plurality of icons that each represent seats around a table in a restaurant. Each icon is associated with a unique account. Accounts can be easily merged and split by using touch and swipe interfaces with the icons.

Abstract: A multi-piston motor/pump is disclosed particularly useful for air motor applications incorporating a cylinder block having a plurality of radially extending pistons and cylinders. Each cylinder is provided with a bronze insert at the top of the cylinder having an intake and exhaust port therein. Rotary valves are mounted on an output shaft and include axial flanges having openings therein that align with the input or exhaust openings in each cylinder. As the rotary valves rotate, the openings therein sequentially align with the input/exhaust ports provided in the bronze inserts such that air or fluid entering each cylinder enters axially of the cylinder. A center mounting plate is secured to the cylinder block and separates the input ports from the exhaust ports to enable fluid flow into the input ports and exhaust from the exhaust ports while isolating each port from the adjacent port in each cylinder.

Abstract: A push-push type fluid pressure actuated motor has one or more radial opposed cylinder sets each having a pair of pistons, a connecting rod, and a Scotch-yoke connection to a crankshaft. An intake rotor valve at one face of the cylinder block and an exhaust rotor valve at an opposite face of the cylinder block are mounted on and rotate with the crankshaft. The rotor valves admit pressurized fluid to the cylinder and allow discharge of spent fluid from the cylinders.