Abstract: An improved therapeutic roller device comprising a cylindrical core and roller members originating from said cylindrical core. The roller members are separated, from each other, by a distance that is intended to generate lateral stretch on a muscle or other soft tissue. The amount of lateral stretch placed on a muscle, or other soft tissue, is proportional to the distance between roller elements up to a maximum distance at which lateral stretch can no longer be achieved. The diameter of the roller members determines the amount of longitudinal stretch placed on a muscle or other soft tissue. Additional longitudinal stretch is attained by ribbing of the roller members so that the roller members have projections. The length of the projections and distance between subsequent projections determine the extent of additional longitudinal stretch that can be placed on a muscle or other soft tissue.

Abstract: A bagless catheter and incontinence device, which reduces maceration, microbial skin infiltration and infection, urinary tract infection, and offers the user a normal, odor-free, active lifestyle, is provided.

Abstract: The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.

Abstract: The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.

Abstract: The present invention relates to methods for using osteocalcin. The invention also relates to methods for using polynucleotides encoding osteocalcin. The invention relates to methods using the osteocalcin polypeptides and polynucleotides as a target for diagnosis and treatment osteocalcin related conditions. The invention further relates to drug-screening methods using the osteocalcin polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the osteocalcin polypeptides and polynucleotides. The invention further relates to agonists and antagonists identified by drug screening methods with the osteocalcin polypeptides and polynucleotides as a target. The invention further related to methods of treating a subject suffering from an osteocalcin mediated condition.

Abstract: The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.