Abstract: The present invention is drawn to a transdermal patch for the delivery of a nitric oxide-donor and a second active agent. The patch can comprise a backing layer and an active agent-containing composition which is supported at least in part by the backing layer. The active agent-containing composition can include an amount of a nitric oxide-donor and an amount of a second active agent. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 ?g/hour to about 85 ?g/hour. The second active agent can be selected from a number of agents including NSAIDS, opioids, local anesthetics, menthol, salicylic acid, salicylic acid derivatives, vanilloid receptor-1 activators, corticosteroids, vasoconstrictors, and combinations thereof.

Abstract: The present invention unexpectedly provides a method for treating acute or chronic tendinopathy by transdermal administration of low-dose glyceryl trinitrate, or other nitric oxide-generating agents. The present invention also provides a method of relieving pain caused by tendinopathy by transdermal administration of low-dose glyceryl trinitrate, or other nitric oxide-generating agents.

Abstract: A peroxisome-associated polypeptide and a nucleotide sequence encoding the peroxisome-associated polypeptide are disclosed. The protein is useful in the diagnosis and/or treatment of several diseases, particularly lung injuries and diseases as well as oxidative stress-related disorders, particularly neurotoxic injury or exitotoxic injury.