Patents by Inventor George P. Casale

George P. Casale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of estrogen-purine base and estrogen-mercapturate adducts and development of fluorescent probes and monoclonal antibodies to assay those adducts
    Patent number: 5952183
    Abstract: Estrogen-nucleoside, estrogen-guanine and estrogen-mercapturate adducts are potential biomarkers for determining susceptibility of animals to a number of estrogen related cancers. These adducts may be used as biomarkers for determining risk of estrogen-induced cancers. A linker chemistry has been devised to couple these adducts to protein for production of immunogens, required for production of specific monoclonal antibodies.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: September 14, 1999
    Inventors: Ercole L. Cavalieri, George P. Casale, Eleanor G. Rogan, Douglas E. Stack
  • Synthesis of estrogen-purine base and estrogen-mercapturate adducts and development of fluorescent probes and monoclonal antibodies to assay those adducts
    Patent number: 5840889
    Abstract: Estrogen-nucleoside, estrogen-guanine and estrogen-mercapturate adducts are potential biomarkers for determining susceptibility of animals to a number of estrogen related cancers. These adducts may be used as biomarkers for determining risk of estrogen-induced cancers. A linker chemistry has been devised to couple these adducts to protein for production of immunogens, required for production of specific monoclonal antibodies.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: November 24, 1998
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Ercole L. Cavalieri, George P. Casale, Eleanor G. Rogan, Douglas E. Stack