Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: A slatted horizontal blinds system has separate positional controls for distinct subsets of slats. Odd and even slats can be moved relative to each other both horizontally and vertically. With a scalloped upper and lower edge, overlapping slats can produce a variety of light allowing and esthetic modes. Some versions only support up and down movement and some slats are rectangular. This is caused by hiding and exposing of slat portions and voids between slats by the relative movement of odd and even slats. Slats may have translucent colored portions, apertures or printed designs. The absolute movement may only be of one subset of slats while other slats stay in position. In other cases all slats can move simultaneously in relation to each other. Mechanisms include screw drive with “lost motion” operation and movement latches. Also slidable carriages, end-cams, and linear motors can be used. In some cases the bottom rail has mechanisms as well as the head rail.

Abstract: A slatted horizontal blinds system has separate positional controls for distinct subsets of slats. Odd and even slats can be moved relative to each other both horizontally and vertically. With a scalloped upper and lower edge, overlapping slats can produce a variety of light allowing and esthetic modes. Some versions only support up and down movement and some slats are rectangular. This is caused by hiding and exposing of slat portions and voids between slats by the relative movement of odd and even slats. Slats may have translucent colored portions, apertures or printed designs. The absolute movement may only be of one subset of slats while other slats stay in position. In other cases all slats can move simultaneously in relation to each other. Mechanisms include screw drive with “lost motion” operation and movement latches. Also slidable carriages, end-cams, and linear motors can be used. In some cases the bottom rail has mechanisms as well as the head rail.

Abstract: A slatted horizontal blinds system has separate positional controls for distinct subsets of slats. Odd and even slats can be moved relative to each other both horizontally and vertically. With a scalloped upper and lower edge, overlapping slats can produce a variety of light allowing and esthetic modes. Some versions only support up and down movement and some slats are rectangular. This is caused by hiding and exposing of slat portions and voids between slats by the relative movement of odd and even slats. Slats may have translucent colored portions, apertures or printed designs. The absolute movement may only be of one subset of slats while other slats stay in position. In other cases all slats can move simultaneously in relation to each other. Mechanisms include screw drive with “lost motion” operation and movement latches. Also slidable carriages, end-cams, and linear motors can be used. In some cases the bottom rail has mechanisms as well as the head rail.

Abstract: A slatted horizontal blinds system has separate positional controls for distinct subsets of slats. Odd and even slats can be moved relative to each other both horizontally and vertically. With a scalloped upper and lower edge, overlapping slats can produce a variety of light allowing and esthetic modes. Some versions only support up and down movement and some slats are rectangular. This is caused by hiding and exposing of slat portions and voids between slats by the relative movement of odd and even slats. Slats may have translucent colored portions, apertures or printed designs. The absolute movement may only be of one subset of slats while other slats stay in position. In other cases all slats can move simultaneously in relation to each other. Mechanisms include screw drive with “lost motion” operation and movement latches. Also slidable carriages, end-cams, and linear motors can be used. In some cases the bottom rail has mechanisms as well as the head rail.

Abstract: A cache-coherent, multiple-bus, multiprocessing system and method interconnects multiple system buses and an I/O bus to a shared main memory and efficiently maintains cache coherency while minimizing the impact to latency and total bandwidth within the system. The system provides coherency filters which coordinate bus-to-bus communications in such a way as to maintain cache memory coherency with a small amount of cross-bus traffic. In addition, the system provides a multiported pool of memory cells which interconnect the multiple buses.

Abstract: A cache-coherent, multiple-bus, multiprocessing system and method interconnects multiple system buses and an I/O bus to a shared main memory and efficiently maintains cache coherency while minimizing the impact to latency and total bandwidth within the system. The system provides coherency filters which coordinate bus-to-bus communications in such a way as to maintain cache memory coherency with a small amount of cross-bus traffic. In addition, the system provides a multiported pool of memory cells which interconnect the multiple buses.

Abstract: A cache-coherent, multiple-bus, multiprocessing system and method interconnects multiple system buses and an I/O bus to a shared main memory and efficiently maintains cache coherency while minimizing the impact to latency and total bandwidth within the system. The system provides coherency filters which coordinate bus-to-bus communications in such a way as to maintain cache memory coherency with a small amount of cross-bus traffic. In addition, the system provides a multiported pool of memory cells which interconnect the multiple buses.