Abstract: A medical connector can include a body having a fluid path with an inlet port, an outlet port, a luer portion, and a post extending through a fluid path. An arm having a latch member is coupled to the body to engage a ridge or thread on an exterior surface of a reciprocal connector. The arm may also include an extension. When the connector is in an open position, the latch member restricts retraction of the reciprocal connector from the outlet port. A seal is coupled to the body and includes a flap extending across the outlet port or a bellows to compress along an axis. In a closed position, the post restricts flow through the luer portion. In an open position, the post permits flow through the luer portion.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: A building system includes one or more storage devices having instructions stored thereon that, when executed by one or more processors, cause the one or more processors to receive an unstructured user question from a user device of a user and query a graph database based on the unstructured user question to extract context associated with the unstructured user question from contextual information of a building stored by the graph database, wherein the graph database stores the contextual information of the building through nodes and edges between the nodes, wherein the nodes represent equipment, spaces, people, and events associated building and the edges represent relationships between the equipment, spaces, people, and events. The instructions further cause the one or more processors to retrieve data from one or more data sources based on the context and compose a presentation based on the retrieved data.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: Provided herein are methods for purifying an anti-?4?7 integrin antibody, such as vedolizumab, from a liquid solution, e.g., from a mammalian cell culture clarified harvest. The invention relates, inter alia, to purification methods for controlling the amount of product-related substances and/or process-related impurities present in purified preparations of an anti-?4?7 integrin antibody, or antigen-binding fragment thereof, e.g., vedolizumab. Compositions comprising an anti-?4?7 antibody, and uses thereof to treat a disorder, are also provided.

Abstract: Methods of purifying a humanized ?4?7 antibody, such as vedolizumab, produced in a mammalian cell culture are described herein, as are compositions resulting from said purification processes.

Abstract: A composition is described which comprises a component which is susceptible to free radical attack, said composition comprising, as a free radical scavenger, at least one particle having a size not exceeding 100 nm of an oxide of a rare earth or transition metal possessing adjacent oxidation states. The composition is preferable a UV sunscreen composition suitable also for cosmetic use.

Abstract: A polymeric composition is described which comprises an amount of one or more organic or inorganic components which are photosensitive and/or which are degraded by another ingredient of the composition and an amount of Ti02 and/or ZnO which has been doped with a second element or the reduced ZnO, this composition having a rate of deterioration of UV light-sensitive physical factor at least 5% less than that of a composition having the same formulation except that it does not contain the said Ti02 and/or ZnO which has been doped with a second element or the said ZnO.

Abstract: A composition is described which comprises an ingredient which is adversely affected by the presence of TiO2 and/or ZnO, and TiO2 and/or ZnO which has been doped with another element and/or reduced ZnO.

Abstract: A UV sunscreening composition suitable for cosmetic or topical pharmaceutical use which comprises an amount of one or more organic components which are photosensitive and/or which are degraded and/or in which degradation is induced by another ingredient of the composition, and an amount of TiO2 and/or ZnO which has been doped with another element and/or reduced zinc oxide, this composition having a rate of loss of UV absorption at least 5% less than that of a composition having the same formulation except that it does not contain the said TiO2 and/or ZnO which has been doped with another element or the said reduced zinc oxide.

Abstract: Centrally apertured discs which are to be subjected on one side to a treatment such as the deposition of a layer of material on the disc are carried on disc holders in a magazine which comprises a pair of opposed parallel walls and which has an open side between these walls through which the disc holders can be inserted in and removed from the magazine. The disc holders each comprise a rigid plate and attachment means for attaching a centrally apertured disc to each side of the plate, the attachment means engaging in the central aperture of each disc. The plate has at least one pair of opposed parallel edges for cooperation with guide rollers which are provided on the inner sides of the opposed walls of the magazine for guiding the disc holders during their insertion in and removal from the magazine in directions parallel to the opposed edges of the plates.