Patents by Inventor George R. Greene, Jr.
George R. Greene, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140257245Abstract: Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Applicant: MicroVention, Inc.Inventors: Robert F. Rosenbluth, George R. Greene, JR., Brian J. Cox, Thomas S. Sternweiler, Sean L. Chow, Richard R. Monetti, Teresa L. Halverson, Maricela D. Walker, Robert Pecor
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Patent number: 8603128Abstract: An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements.Type: GrantFiled: January 29, 2009Date of Patent: December 10, 2013Assignee: MicroVention, Inc.Inventors: George R. Greene, Jr., Gregory M. Cruise, Michael Constant, Brian J. Cox, Terrance Tran
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Patent number: 8323306Abstract: A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. Confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow.Type: GrantFiled: April 5, 2006Date of Patent: December 4, 2012Assignee: MicroVention, Inc.Inventors: Dean Schaefer, Brian J. Cox, George R. Greene, Jr., David A. Ferrera, Matthew Fitz, Robert F. Rosenbluth
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Publication number: 20110005062Abstract: A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site.Type: ApplicationFiled: September 8, 2010Publication date: January 13, 2011Inventors: George R. Greene, JR., Robert F. Rosenbluth, Brian J. Cox
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Patent number: 7842054Abstract: An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements.Type: GrantFiled: February 8, 2006Date of Patent: November 30, 2010Assignee: MicroVention, Inc.Inventors: George R. Greene, Jr., Gregory M. Cruise, Michael Constant, Brian J. Cox, Terrance Tran
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Patent number: 7799047Abstract: A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site.Type: GrantFiled: December 17, 2008Date of Patent: September 21, 2010Assignee: MicroVention, Inc.Inventors: George R. Greene, Jr., Robert F. Rosenbluth, Brian J. Cox
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Publication number: 20090232869Abstract: An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements.Type: ApplicationFiled: January 29, 2009Publication date: September 17, 2009Inventors: George R. Greene, JR., Gregory M. Cruise, Michael Constant, Brian J. Cox, Terrance Tran
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Publication number: 20090112250Abstract: A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site.Type: ApplicationFiled: December 17, 2008Publication date: April 30, 2009Inventors: George R. Greene, JR., Robert F. Rosenbluth, Brian J. Cox
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Patent number: 7491214Abstract: An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements.Type: GrantFiled: September 24, 2003Date of Patent: February 17, 2009Assignee: MicroVention, Inc.Inventors: George R. Greene, Jr., Gregory M. Cruise, Michael Constant, Brian J. Cox, Terrance Tran
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Patent number: 7483558Abstract: A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site.Type: GrantFiled: April 10, 2007Date of Patent: January 27, 2009Assignee: MicroVention, Inc.Inventors: George R. Greene, Jr., Robert F. Rosenbluth, Brian J. Cox
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Patent number: 7331974Abstract: A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the minimum energy state secondary configuration comprises a plurality of tangentially-interconnected, substantially circular loops defining a plurality of discrete axes. In an alternative embodiment, the minimum energy state secondary configuration defines a wave-form like structure comprising a longitudinal array of laterally-alternating open loops defining a plurality of separate axes. In either embodiment, the device, in its minimum energy state secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site in which the device is to be deployed.Type: GrantFiled: August 11, 2003Date of Patent: February 19, 2008Assignee: Microvention, Inc.Inventors: Dean Schaefer, Horacio Almazan, David A. Ferrera, Brian J. Cox, George R. Greene, Jr.
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Patent number: 7201762Abstract: A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site.Type: GrantFiled: December 16, 2002Date of Patent: April 10, 2007Assignee: Microvention, Inc.Inventors: George R. Greene, Jr., Robert F. Rosenbluth, Brian J. Cox
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Patent number: 7033374Abstract: A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral.Type: GrantFiled: January 11, 2002Date of Patent: April 25, 2006Assignee: Microvention, Inc.Inventors: Dean Schaefer, Brian J. Cox, George R. Greene, Jr., David A. Ferrera, Matthew Fitz, Robert F. Rosenbluth
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Patent number: 7029487Abstract: A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site.Type: GrantFiled: December 4, 2002Date of Patent: April 18, 2006Assignee: Microvention, Inc.Inventors: George R. Greene, Jr., Robert F. Rosenbluth, Brian J. Cox
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Patent number: 7029486Abstract: A microcoil vaso-occlusive device has a minimum energy state secondary configuration having a plurality of curved segments, each defining a discrete axis. The secondary configuration may be a plurality of interconnected closed loops; an array of laterally-alternating open loops; a series of tangential closed loops; or a logarithmic spiral. The device, in its secondary cofiguration, has a dimension that is substantially larger than the largest dimension of the vascular site in which it is to be deployed. Thus, confinement of the device within the site causes it to assume a configuration with a higher energy state than the minimum energy state. Because the secondary configuration is larger (in at least one dimension) than the site, the device is constrained, by contact with the walls of the site, from returning to its secondary configuration, and shifting of the device due to blood flow is minimized.Type: GrantFiled: September 19, 2002Date of Patent: April 18, 2006Assignee: Microvention, Inc.Inventors: Dean Schaefer, Brian J. Cox, George R. Greene, Jr., David A. Ferrera, Matthew Fitz, Robert F. Rosenbluth
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Patent number: 7014645Abstract: An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements.Type: GrantFiled: May 29, 2002Date of Patent: March 21, 2006Assignee: Microvention Inc.Inventors: George R. Greene, Jr., Gregory M. Cruise, Michael Constant, Brian J. Cox, Terrance Tran
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Patent number: 6689141Abstract: A mechanism for the deployment of a filamentous endovascular device includes a flexible deployment tube having an open proximal end, and a coupling element attached to the proximal end of the endovascular device. The deployment tube includes a distal section terminating in an open distal end, with a lumen defined between the proximal and distal ends. A retention sleeve is fixed around the distal section and includes a distal extension extending a short distance past the distal end of the deployment tube. The endovascular device is attached to the distal end of the deployment tube by fixing the retention sleeve around the coupling element, so that the coupling element is releasably held within the distal extension of the deployment tube. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly through a microcatheter to a target vascular site until the endovascular device is located within the site.Type: GrantFiled: May 10, 2002Date of Patent: February 10, 2004Assignee: MicroVention, Inc.Inventors: David A. Ferrera, George R. Greene, Jr., Brian J. Cox, Robert F. Rosenbluth
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Patent number: 6607538Abstract: A mechanism for the deployment of an endovascular device having a coupling element attached to its proximal end, includes a deployment tube having a proximal end, a distal section, open distal end, and a lumen extending between the proximal and distal ends. A retention sleeve, fixed around the distal section, includes an extension extending past the distal end of the tube. The retention sleeve is fixed around the coupling element, so that the coupling element is releasably held within the extension. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly until the device is deployed within a target site. A liquid is injected through the lumen so as to push the coupling element out of the retention sleeve by fluid pressure, thereby detaching the endovascular device from the deployment tube.Type: GrantFiled: October 18, 2000Date of Patent: August 19, 2003Assignee: Microvention, Inc.Inventors: David A. Ferrera, George R. Greene, Jr., Brian J. Cox, Robert F. Rosenbluth
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Patent number: 6605101Abstract: A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the minimum energy state secondary configuration comprises a plurality of tangentially-interconnected, substantially circular loops defining a plurality of discrete axes. In an alternative embodiment, the minimum energy state secondary configuration defines a wave-form like structure comprising a longitudinal array of laterally-alternating open loops defining a plurality of separate axes. In either embodiment, the device, in its minimum energy state secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site in which the device is to be deployed.Type: GrantFiled: September 26, 2000Date of Patent: August 12, 2003Assignee: Microvention, Inc.Inventors: Dean Schaefer, Horacio Almazan, David A. Ferrera, Brian J. Cox, George R. Greene, Jr.
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Patent number: 6602261Abstract: An embolization device includes one or more expansible, hydrophilic embolizing elements non-releasably carried along the length of a filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In a second embodiment, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip. In either of the embodiments, the embolizing elements may be made of a hydrophilic, macroporous, polymeric, hydrogel foam material.Type: GrantFiled: May 29, 2001Date of Patent: August 5, 2003Assignee: Microvention, Inc.Inventors: George R. Greene, Jr., Gregory M. Cruise, Michael Constant, Brian J. Cox