Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.

Abstract: A pixel for an ambient light and/or color sensor includes a plurality of pinned photodiodes. The pixel also includes a floating diffusion region. A ratio of an active area of the plurality of pinned photodiodes to an area of the floating diffusion region is greater than 150.

Abstract: In one embodiment, a method includes transmitting pulse power on two wire pairs, the pulse power comprising a plurality of high voltage pulses with the high voltage pulses on the wire pairs offset between the wire pairs to provide continuous power, performing low voltage fault detection on each of the wire pairs between the high voltage pulses, and transmitting data on at least one of the wire pairs during transmittal of the high voltage pulses. Data transmittal is suspended during the low voltage fault detection.

Abstract: A data packet communication system is described, which can be implemented as a physical push based data packet communication device, such as a router, a gateway, or a controller circuit coupled to a router or a gateway adapted for controlling data packet communications. The data packet communication system is adapted to evaluate network capacity of each of the multiple networks at the time of a monitored communication event and assigns data packets accordingly.

Abstract: In an implementation, a hydraulic valve includes a valve body, a cylindrical chamber within the valve body, and a cylindrical spool within the chamber. The spool is rotatable between at least a first position and a second position about a longitudinal axis parallel to a longitudinal axis of the chamber. The spool includes a landing and an eccentric channel that extends around a portion of an outer circumferential surface of the landing. In the first position, an inlet and an outlet of the hydraulic valve are fluidly coupled by the eccentric channel to allow a flow of a hydraulic fluid circumferentially around the landing from the inlet to the outlet. In the second position, the inlet and/or the outlet are obstructed by another portion of the outer circumferential surface of the landing to prevent the flow of the hydraulic fluid from the inlet to the outlet.

Abstract: A method and system for acceptance data inputs required for a complete resolution of analytical or documentation process, wherein at least one subprocess can be fully resolved by receipt, recognition and application of a subset of the plurality of data inputs. Some data input is applicable in more than one subprocess of the process. A resolution of the at least one subprocess may lead to an immediate resolution of the process in a negative and/or a positive finding. Resolutions of one or more subprocesses may be indicated and/or be rendered by means of a graphical user interface. A derived value result of the subprocess, a conditional result, a negative result of the subprocess, and/or a positive result of the subprocess is communicated via an electronic communications network. One or more variations of the process evaluates data required by or related to real estate transactions and/or real estate loan qualifications.

Abstract: An improved data packet communications approach is described that is adapted for communications across unreliable connections. In particular, the approach can be implemented as systems and methods for a networked router device configured to monitor communication characteristics and to group the connections into various tiers based on their communication reliability data. When a new packet is to be communicated, the grouped connections are utilized in aggregate to meet a target transmission reliability probability (e.g., target value or a band of values).

Abstract: Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase.

Abstract: The present disclosure describes a method and apparatus that can be used to adjust for distorted ambient light readings caused by the ambient light sensor being located behind the display screen. The strategy of the disclosure relies, at least in part, on spectral decomposition of ambient light measurements into independent sources (e.g., red, green, and blue display components of an Organic Light Emitting Diode (“OLED”) display screen and ambient light). Following the spectral decomposition technique, a more accurate ambient light measurement can be obtained in some instances. This technique enables determinations such as ambient lux and correlated color temperature independent of the content displayed on the screen.

Abstract: Techniques are described for portable computing devices and other apparatus that include an ambient light sensor. The techniques can be particularly advantageous for situations in which the ambient light sensor is disposed behind a display screen of a host device such that ambient light detected by the sensor passes through the light emitting display before being detected by the sensor.

Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.

Abstract: A method for estimating ambient light at a display screen of a device. The method comprises determining one or more expected colour values of display screen output light, detecting light with a sensor positioned behind the display screen, determining one or more colour values of the detected light, determining a difference between the one or more expected colour values of the display screen output light and the one or more colour values of the detected light, and, from the determined difference, estimating a first portion of the detected light corresponding to the display screen output light and a second portion of the detected light corresponding to ambient light.

Abstract: An apparatus includes a display screen, an ambient light sensor disposed behind the display screen, and an electronic control unit operable to control a brightness of the display screen based on a duty cycle of a PWM signal. The electronic control unit is operable to sample an output of the ambient light sensor, identify a pair of consecutive samples of the ambient light sensor output that represent a greatest difference in magnitudes of their values, and to estimate a brightness of the display screen based on the difference.

Abstract: The present invention relates to a system and method for receiving diagnostic and vital signs information remotely from a patient and providing treatment information to the patient. The system includes a plurality of wireless diagnostic tools to measure one or more vital signs of a patient, a computer implemented software platform configured to receive vital sign information from the one or more wireless diagnostic tools wirelessly or through manual input from a user. A healthcare provider system receives vital sign information of the patient from the computer implemented software through the internet. A doctor reviews the vital signs information of the patient and provides necessary advice to the patient. The system and method eliminate the need to physically visit a doctor's office for a simple physical or checkup and enables a healthcare provider to remotely obtain patient vital signs information.

Abstract: The present disclosure describes a method and apparatus that can be used to adjust for distorted ambient light readings caused by the ambient light sensor being located behind the display screen. The strategy of the disclosure relies, at least in part, on spectral decomposition of ambient light measurements into independent sources (e.g., red, green, and blue display components of an Organic Light Emitting Diode (“OLED”) display screen and ambient light). Following the spectral decomposition technique, a more accurate ambient light measurement can be obtained in some instances. This technique enables determinations such as ambient lux and correlated color temperature independent of the content displayed on the screen.

Abstract: An apparatus includes a display screen, and an optical proximity sensor module disposed behind the display screen. The optical proximity sensor module includes a light emitter operable to produce light having a wavelength for transmission through the display screen toward a target object, and a light sensor operable to sense light reflected by the target object and having the wavelength. The optical proximity sensor module can includes means for reducing a maximum energy density of a light beam produced by the light emitter. The means for reducing the maximum energy density of the light beam is disposed between the light emitter and the display screen so as to intersect the light beam produced by the light emitter. In some cases, there are multiple light emitters collectively operable to provide sufficient optical energy for proximity sensing without producing a visible spot on the display screen.

Abstract: An apparatus includes a display screen, an ambient light sensor disposed behind the display screen, and an electronic control unit. An integration time of the ambient light sensor is unsynchronized to a frame rate of the display screen. The electronic control unit is operable to control a brightness of the display screen based on a duty cycle of a PWM blanking signal, wherein at least one OFF time of the PWM blanking signal occurs fully within a first integration period of the ambient light sensor, and wherein at least one other integration period ON time of the PWM blanking signal occurs fully during an ON time of the PWM blanking signal. The electronic control unit is further operable to acquire samples of an output of the ambient light sensor, to identify a highest value and a lowest value from among a consecutive group of the samples, and to estimate a magnitude of an ambient light signal based at least in part on the highest value and the lowest value.

Abstract: A method for estimating ambient light at a display screen of a device. The method comprises determining one or more expected colour values of display screen output light, detecting light with a sensor positioned behind the display screen, determining one or more colour values of the detected light, determining a difference between the one or more expected colour values of the display screen output light and the one or more colour values of the detected light, and, from the determined difference, estimating a first portion of the detected light corresponding to the display screen output light and a second portion of the detected light corresponding to ambient light.

Abstract: Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase.