Patents by Inventor George Tsu-Chih Chiu
George Tsu-Chih Chiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11782007Abstract: The present disclosure relates to a novel composite film configured for CO2 sensing, and the method of making and using the novel composite film. The novel composite film comprises a carbon nanotube film and a CO2 absorbing layer deposited on the carbon nanotube film, wherein the CO2 absorbing layer comprises a mixture of a branched polyethylenimine, a polyethylene glycol, and poly[1-(4-vinylbenzyl)-3-methylimidazolium tetrafluoroborate] of formula I: wherein n ranges from 10-300.Type: GrantFiled: August 6, 2020Date of Patent: October 10, 2023Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Bryan W Boudouris, Nikhil Bajaj, Allison Kelly Murray, Zachary A Siefker, Xikang Zhao
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Patent number: 11718823Abstract: The present disclosure relates to a novel method for rapid preparation of three dimensional (3D) spheroids/organoids, and the 3D spheroids/organoids prepared by the novel method.Type: GrantFiled: December 1, 2020Date of Patent: August 8, 2023Assignee: Purdue Research FoundationInventors: Bumsoo Han, George Tsu-Chih Chiu, Cih Cheng
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Patent number: 11660806Abstract: Three-dimensional (3D) printed fluoropolymer-based energetic compositions are made using 3D printing methods. The 3D printed fluoropolymer-based energetic compositions comprise a fluoropolymer and a reactive metal or metal oxide. The total weight percentage of the fluoropolymer and the reactive metal or metal oxide is 70-100% of the 3D printed fluoropolymer-based energetic composition, and the weight percentage of the reactive metal or metal oxide is 5-85 wt % of the total weight of the 3D printed fluoropolymer-based energetic material. The 3D printed fluoropolymer-based energetic material has a thickness of at least 200 ?m.Type: GrantFiled: September 2, 2020Date of Patent: May 30, 2023Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Ibrahim Emre Gunduz, Trevor John Fleck, Allison Kelly Murray, Steven Forrest Son
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Patent number: 11420387Abstract: This disclosure generally relates to methods and apparatus for 3D printing of highly viscous materials, especially to high amplitude ultrasonic vibration facilitated lower temperature 3D printing of highly viscous materials with a viscosity of at least 1000 Pa·s.Type: GrantFiled: November 3, 2020Date of Patent: August 23, 2022Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Ibrahim Emre Gunduz, Steven Forrest Son, George Tsu-Chih Chiu
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Patent number: 11273447Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.Type: GrantFiled: January 13, 2020Date of Patent: March 15, 2022Assignee: Purdue Research FoundationInventors: Bumsoo Han, George Tsu-Chih Chiu, Thomas Heinrich Siegmund, Michael Linnes, Yumeng Wu, Matthew Tyler Short
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Publication number: 20220003760Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material, wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte.Type: ApplicationFiled: February 10, 2021Publication date: January 6, 2022Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Eric A. Nauman, Mackenzie Tweardy, Michael Wadas, Allison Kelly Murray, George Tsu-Chih Chiu, Nikhil Bajaj
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Publication number: 20210238541Abstract: The present disclosure relates to a novel method for rapid preparation of three dimensional (3D) spheroids/organoids, and the 3D spheroids/organoids prepared by the novel method.Type: ApplicationFiled: December 1, 2020Publication date: August 5, 2021Applicant: Purdue Research FoundationInventors: Bumsoo Han, George Tsu-Chih Chiu, Cih Cheng
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Publication number: 20210231646Abstract: A ?PAD may include a substrate comprising a substrate. The ?PAD may further include a non-polar material printed on a surface of the substrate such that a portion the surface is exposed. The exposed portion may include a receiving area, a plurality of test areas, and a plurality of channels disposed between the receiving area and the test areas. The ?PAD may further include colorimetric sensors respectively positioned in the test areas. The channel regions may be configured to receive an analyte solution from the receiving area and direct the analyte solution to the colorimetric sensors. A system may perform image processing on captured images of the ?PAD to provide multiplexed analysis of analyte solutions applied to the ?PAD.Type: ApplicationFiled: January 28, 2021Publication date: July 29, 2021Applicant: Purdue Research FoundationInventors: Lia Antoaneta Stanciu-Gregory, Jan P. Allebach, George Tsu-Chih Chiu, Lixby S. Diaz, Min Zhao
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Patent number: 11060998Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.Type: GrantFiled: December 4, 2018Date of Patent: July 13, 2021Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Nikhil Bajaj
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Patent number: 11027484Abstract: Three-dimensional (3D) printed fluoropolymer-based energetic compositions are made using 3D printing methods. The 3D printed fluoropolymer-based energetic compositions comprise a fluoropolymer and a reactive metal or metal oxide. The total weight percentage of the fluoropolymer and the reactive metal or metal oxide is 70-100% of the 3D printed fluoropolymer-based energetic composition, and the weight percentage of the reactive metal or metal oxide is 5-85 wt % of the total weight of the 3D printed fluoropolymer-based energetic material. The 3D printed fluoropolymer-based energetic material has a thickness of at least 200 ?m.Type: GrantFiled: March 14, 2018Date of Patent: June 8, 2021Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Ibrahim Emre Gunduz, Trevor John Fleck, Allison Kelly Murray, Steven Forrest Son
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Patent number: 10948489Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte.Type: GrantFiled: July 19, 2018Date of Patent: March 16, 2021Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Eric A. Nauman, Mackenzie Tweardy, Michael Wadas, Allison Kelly Murray, George Tsu-Chih Chiu, Nikhil Bajaj
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Publication number: 20210046701Abstract: This disclosure generally relates to methods and apparatus for 3D printing of highly viscous materials, especially to high amplitude ultrasonic vibration facilitated lower temperature 3D printing of highly viscous materials with a viscosity of at least 1000 Pa·s.Type: ApplicationFiled: November 3, 2020Publication date: February 18, 2021Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Ibrahim Emre Gunduz, Steven Forrest Son, George Tsu-Chih Chiu
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Publication number: 20210041387Abstract: The present disclosure relates to a novel composite film configured for CO2 sensing, and the method of making and using the novel composite film. The novel composite film comprises a carbon nanotube film and a CO2 absorbing layer deposited on the carbon nanotube film, wherein the CO2 absorbing layer comprises a mixture of a branched polyethylenimine, a polyethylene glycol, and poly[1-(4-vinylbenzyl)-3-methylimidazolium tetrafluoroborate] of formula I: wherein n ranges from 10-300.Type: ApplicationFiled: August 6, 2020Publication date: February 11, 2021Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Bryan W Boudouris, Nikhil Bajaj, Allison Kelly Murray, Zachary A Siefker, Xikang Zhao
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Publication number: 20200398479Abstract: The present disclosure relates to three-dimensional (3D) printed fluoropolymer-based energetic compositions and 3D printing methods for making the 3D printed fluoropolymer-based energetic compositions.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Ibrahim E. Gunduz, Trevor J. Fleck, Allison K. Murray, Steven F. Son
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Patent number: 10870234Abstract: This disclosure generally relates to methods and apparatus for 3D printing of highly viscous materials, especially to high amplitude ultrasonic vibration facilitated lower temperature 3D printing of highly viscous materials with a viscosity of at least 1000 Pa·s.Type: GrantFiled: November 7, 2017Date of Patent: December 22, 2020Assignee: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Ibrahim Emre Gunduz, Steven Forrest Son, George Tsu-Chih Chiu
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Publication number: 20200222898Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.Type: ApplicationFiled: January 13, 2020Publication date: July 16, 2020Inventors: Bumsoo Han, George Tsu-Chih Chiu, Thomas Heinrich Siegmund, Michael Linnes, Yument Wu, Matthew Tyler Short
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Publication number: 20200064310Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.Type: ApplicationFiled: December 4, 2018Publication date: February 27, 2020Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Nikhil Bajaj
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Publication number: 20190283319Abstract: This disclosure generally relates to methods and apparatus for 3D printing of highly viscous materials, especially to high amplitude ultrasonic vibration facilitated lower temperature 3D printing of highly viscous materials with a viscosity of at least 1000 Pa·s.Type: ApplicationFiled: November 7, 2017Publication date: September 19, 2019Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Ibrahim Emre Gunduz, Steven Forrest Son, George Tsu-Chih Chiu
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Publication number: 20190030789Abstract: The present disclosure relates to three-dimensional (3D) printed fluoropolymer-based energetic compositions and 3D printing methods for making the 3D printed fluoropolymer-based energetic compositions.Type: ApplicationFiled: March 14, 2018Publication date: January 31, 2019Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Ibrahim E. Gunduz, Trevor J. Fleck, Allison K. Murray, Steven F. Son
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Publication number: 20190025296Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte.Type: ApplicationFiled: July 19, 2018Publication date: January 24, 2019Applicant: Purdue Research FoundationInventors: Jeffrey Frederick Rhoads, Eric A. Nauman, Mackenzie Tweardy, Michael Wadas, Allison Kelly Murray, George Tsu-Chih Chiu, Nikhil Bajaj