Patents by Inventor George W. J. Fleet
George W. J. Fleet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9199935Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.Type: GrantFiled: April 7, 2014Date of Patent: December 1, 2015Assignee: Acetelion Pharmaceuticals Ltd.Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
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Patent number: 9089515Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: GrantFiled: March 7, 2011Date of Patent: July 28, 2015Assignees: Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics CorporationInventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Patent number: 8975280Abstract: A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2; Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.Type: GrantFiled: May 22, 2007Date of Patent: March 10, 2015Assignee: The Chancellor, Masters and Scholars of The University of OxfordInventors: Terry D. Butters, Raymond A. Dwek, George W. J. Fleet
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Publication number: 20140303208Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.Type: ApplicationFiled: April 7, 2014Publication date: October 9, 2014Applicant: Actelion Pharmaceuticals Ltd.Inventors: Terence D. BUTTERS, Raymond A. DWEK, George W. J. FLEET, Michael Glen ORCHARD, Frances Mary PLATT
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Patent number: 8729099Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.Type: GrantFiled: August 3, 2005Date of Patent: May 20, 2014Assignee: Actelion Pharmaceuticals Ltd.Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
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Publication number: 20110184019Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: ApplicationFiled: March 7, 2011Publication date: July 28, 2011Inventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Patent number: 7816560Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: GrantFiled: August 10, 2000Date of Patent: October 19, 2010Assignees: Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics CorporationInventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Publication number: 20100137365Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: ApplicationFiled: January 28, 2010Publication date: June 3, 2010Inventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W.J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Publication number: 20070275998Abstract: A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2;Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.Type: ApplicationFiled: May 22, 2007Publication date: November 29, 2007Inventors: Terry D. Butters, Raymond A. Dwek, George W.J. Fleet
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Patent number: 6916948Abstract: Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic surfactants.Type: GrantFiled: September 12, 2001Date of Patent: July 12, 2005Assignee: Isis Innovation LimitedInventors: George W. J. Fleet, David Scott, Malcolm Finn, Thomas Krūlle
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Patent number: 5384417Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.Type: GrantFiled: January 18, 1994Date of Patent: January 24, 1995Assignee: Monsanto CompanyInventors: George W. J. Fleet, Bryan G. Winchester
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Patent number: 5300659Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.Type: GrantFiled: June 14, 1993Date of Patent: April 5, 1994Assignee: Monsanto CompanyInventors: George W. J. Fleet, Bryan G. Winchester
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Patent number: 5286877Abstract: 1,4-Dideoxy-1,4-imino-L-arabinitol is chemically synthesized from D-lyxonolactone by formation of the pyrrolidine ring by joining the nitrogen between C-1 and C-4 and inversion of configuration at both C-2 and C-4, with the C-3 and C-5 hydroxyl groups being protected throughout the synthesis sequence by benzylidenation. The product is preferably isolated as the hydrochloride salt and is useful as an inhibitor of .alpha.-glucosidase and human immunodeficiency virus (HIV).Type: GrantFiled: February 1, 1993Date of Patent: February 15, 1994Assignee: G. D. Searle & Co.Inventors: James R. Behling, John R. Medich, Kevin A. Babiak, George W. J. Fleet
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Patent number: 5250703Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.Type: GrantFiled: September 29, 1992Date of Patent: October 5, 1993Assignee: Monsanto CompanyInventors: George W. J. Fleet, Bryan G. Winchester
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Patent number: 5248779Abstract: Nojirimycin .delta.-lactam and deoxynojirimycin are each synthesized from 5,6-anhydro-3-O-benzyl-1,2-O-isopropylidene-L-idofuranose as a divergent intermediate by a method which comprises formation of the piperidine ring by connection of nitrogen between C-1 and C-5 with inversion of configuration at C-5 to form nojirimycin .delta.-lactam or between C-2 and C-6 with inversion of configuration at C-2.Type: GrantFiled: September 24, 1992Date of Patent: September 28, 1993Assignee: Monsanto CompanyInventor: George W. J. Fleet
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Patent number: 5210089Abstract: The novel D-rhamnono-? ,5-lactone and a novel method of synthesis of said compound from the monoacetonide of L-gulono-.gamma.-lactone is disclosed. D-Rhamnono-1,5-lactone is a potent inhibitor of .alpha.-and .beta.-mannosidases but not of .alpha.-rhamnosidase.Type: GrantFiled: February 4, 1992Date of Patent: May 11, 1993Assignee: Monsanto CompanyInventors: George W. J. Fleet, Bryan G. Winchester
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Patent number: 5200523Abstract: Nojirimycin .delta.-lactam and deoxynojirimycin are each synthesized from 5,6-anhydro-3-O-benzyl-1,2-O-isopropylidene-L-idofuranose as a divergent intermediate by a method which comprises formation of the piperidine ring by connection of nitrogen between C-1 and C-5 with inversion of configuration at C-5 to form nojirimycin .delta.-lactam or between C-2 and C-6 with inversion of configuration at C-2.Type: GrantFiled: June 17, 1991Date of Patent: April 6, 1993Assignee: Monsanto CompanyInventor: George W. J. Fleet
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Patent number: 5153325Abstract: The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.Type: GrantFiled: March 20, 1992Date of Patent: October 6, 1992Assignee: Monsanto CompanyInventors: George W. J. Fleet, Sung K. Namgoong
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Patent number: 5136036Abstract: .alpha.-Homojirimycin and 6-dpi-homojirimycin are each synthesized from 2-azido-2-deoxy-3,4:6,7-di-O- isopropylidene-D-glydero-D-talo-heptono-1,5-lactone in which the side chain acetonide is hydrolyzed to give the corresponding diol which is then protected with a silyl protecting agent to form a silyl ether. The latter compound is used as a divergent intermediate in which the piperidine ring is formed by joining the nitrogen function at C-2 to C-6 (A) with inversion of configuration at C-6 to form 6-epi-homomannojirimycin or (B) with retention of configuration at C-6 to form .alpha.-homomannojirimycin.Type: GrantFiled: December 17, 1990Date of Patent: August 4, 1992Assignee: Monsanto CompanyInventors: George W. J. Fleet, Ian Bruce
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Patent number: 5100797Abstract: The synthesis of the novel fucosidase inhibitors, .beta.-L-homofuconojirimycin and related 1-.beta.-C-substituted deoxymannojirimycins, is disclosed.Type: GrantFiled: June 27, 1989Date of Patent: March 31, 1992Assignee: Monsanto CompanyInventors: George W. J. Fleet, Sung K. Namgoong