Patents by Inventor George W. Singletary
George W. Singletary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8735652Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (USX) genes.Type: GrantFiled: September 13, 2012Date of Patent: May 27, 2014Assignee: Pioneer Hi-Bred International IncInventors: Xiaoming Bao, George W Singletary, Deborah J Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A Selinger
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Publication number: 20130014290Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (USX) genes.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: PIONEER HI BRED INTERNATIONAL, INCInventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 8293973Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: GrantFiled: August 2, 2011Date of Patent: October 23, 2012Assignee: Pioneer Hi Bred International IncInventors: Xiaoming Bao, George W Singletary, Deborah J Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A Selinger
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Publication number: 20120005780Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: ApplicationFiled: August 2, 2011Publication date: January 5, 2012Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 8017831Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: GrantFiled: June 18, 2009Date of Patent: September 13, 2011Assignee: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 7829760Abstract: Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided.Type: GrantFiled: August 4, 2008Date of Patent: November 9, 2010Assignee: Pioneer Hi-Bred International, Inc.Inventors: Matthias Liebergesell, Jinrui Shi, George W. Singletary
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Publication number: 20090260105Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: ApplicationFiled: June 18, 2009Publication date: October 15, 2009Applicant: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 7592505Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: GrantFiled: December 21, 2006Date of Patent: September 22, 2009Assignee: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Publication number: 20080320613Abstract: Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided.Type: ApplicationFiled: August 4, 2008Publication date: December 25, 2008Applicant: Pioneer Hi-Bred International, Inc.Inventors: Matthias Liebergesell, Jinrui Shi, George W. Singletary
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Patent number: 7411113Abstract: Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided.Type: GrantFiled: February 23, 2005Date of Patent: August 12, 2008Assignee: Pioneer Hi-Bred International, Inc.Inventors: Matthias Liebergesell, Jinrui Shi, George W. Singletary
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Patent number: 7317146Abstract: The invention alters the physical characteristics of starch granules in a plant. Methods are provided for reducing starch granule size by stably introducing into the genome of the plant or plant cell a DNA construct comprising a polynucleotide encoding a polypeptide operably linked to a promoter that drives expression in a plant and operably linked to a plastid transit peptide. Compositions of the invention include transgenic plants and seeds having a reduced starch granule size. Compositions also include starch isolated from these plants and seeds. The modified starch granules find use in a wide range of food, feed, and industrial applications.Type: GrantFiled: December 22, 2004Date of Patent: January 8, 2008Assignee: Pioneer Hi-Bred International, Inc.Inventors: George W. Singletary, Lan Zhou
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Publication number: 20070261136Abstract: The present invention is directed to compositions and methods for producing a dominant high-amylopectin starch trait in cereal grain and methods for screening grain for genetic variation in hydrolysis and fermentation time.Type: ApplicationFiled: April 30, 2007Publication date: November 8, 2007Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: George W. Singletary, Lan Zhou, Kimberly F. Glassman, Douglas M. Haefele
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Patent number: 7098381Abstract: Methods are provided that diminish UDPGdH expression in plant cells as compared to wild-type plant cells. These methods find use in increasing the nutritional value of animal feed and improving processes for extraction of starch from plant seeds. Also provided are expression vectors capable of diminishing UDPGdH expression in plant cells, and transgenic plants expressing diminished levels of UDPGdH.Type: GrantFiled: March 13, 2002Date of Patent: August 29, 2006Assignee: Pioneer Hi-Bred International, Inc.Inventors: George W. Singletary, Scott E. Nichols, Kanwarpal S. Dhugga
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Patent number: 6734341Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in starch biosynthesis. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering the amount and/or morphology of starch in plants.Type: GrantFiled: January 11, 2002Date of Patent: May 11, 2004Assignee: Pioneer Hi-Bred International, Inc.Inventors: George W. Singletary, Lan Zhou
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Publication number: 20040025203Abstract: Methods are provided that diminish UDPGdH expression in plant cells as compared to wild-type plant cells. These methods find use in increasing the nutritional value of animal feed and improving processes for extraction of starch from plant seeds. Also provided are expression vectors capable of diminishing UDPGdH expression in plant cells, and transgenic plants expressing diminished levels of UDPGdH.Type: ApplicationFiled: March 13, 2002Publication date: February 5, 2004Inventors: George W. Singletary, Scott E. Nichols, Kanwarpal S. Dhugga
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Patent number: 6639126Abstract: The invention alters the physical characteristics of storage polyglucans including starch. Methods are provided to modify the polyglucan biosynthesis pathway by simultaneously altering the activity of a pullulanase debranching enzyme and the activity of another polypeptide in the polyglucan biosynthesis pathway. Compositions of the invention include transgenic plants and seeds having a modified polyglucan structure and/or content and elevated phytoglycogen levels. Additional compositions include a grain with increased energy availability for improved feed quality and industrial uses. Further compositions include a polyglucan with improved functional properties useful in a wide range of food and industrial applications.Type: GrantFiled: December 6, 2000Date of Patent: October 28, 2003Assignee: Pioneer Hi-Bred International, Inc.Inventors: Vincent J. H. Sewalt, George W. Singletary
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Publication number: 20030135883Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in starch biosynthesis. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering the amount and/or morphology of starch in plants.Type: ApplicationFiled: January 11, 2002Publication date: July 17, 2003Inventors: George W. Singletary, Lan Zhou
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Patent number: 6423886Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in starch biosynthesis. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering the amount and/or morphology of starch in plants.Type: GrantFiled: September 2, 1999Date of Patent: July 23, 2002Assignee: Pioneer Hi-Bred International, Inc.Inventors: George W. Singletary, Lan Zhou
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Patent number: 6399859Abstract: Isolated nucleic acid molecules are provided that encode maize UDPGdH variant UDPGdH, and mutant UDPGdH proteins. These nucleic acid molecules can be used to produce transgenic plants having altered quality or quantity of starch. Also provided are vectors capable of expressing such nucleic acid molecules, host cells containing, such vectors, and polypeptides encoded by such nucleic acids.Type: GrantFiled: December 10, 1997Date of Patent: June 4, 2002Assignee: Pioneer Hi-Bred International, Inc.Inventors: Scott E. Nichols, Kanwarpal S. Dhugga, George W. Singletary, Court A. Saunders, Derrick Witcher, Wesley B. Bruce, Lynne E. Sims, Guihua Lu, Gan-Yuan Zhong