Patents by Inventor George W. Singletary

George W. Singletary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8735652
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (USX) genes.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 27, 2014
    Assignee: Pioneer Hi-Bred International Inc
    Inventors: Xiaoming Bao, George W Singletary, Deborah J Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A Selinger
  • Publication number: 20130014290
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (USX) genes.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 10, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL, INC
    Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
  • Patent number: 8293973
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: October 23, 2012
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Xiaoming Bao, George W Singletary, Deborah J Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A Selinger
  • Publication number: 20120005780
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.
    Type: Application
    Filed: August 2, 2011
    Publication date: January 5, 2012
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A. Selinger
  • Patent number: 8017831
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: September 13, 2011
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
  • Patent number: 7829760
    Abstract: Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: November 9, 2010
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Matthias Liebergesell, Jinrui Shi, George W. Singletary
  • Publication number: 20090260105
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 15, 2009
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
  • Patent number: 7592505
    Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: September 22, 2009
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
  • Publication number: 20080320613
    Abstract: Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided.
    Type: Application
    Filed: August 4, 2008
    Publication date: December 25, 2008
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Matthias Liebergesell, Jinrui Shi, George W. Singletary
  • Patent number: 7411113
    Abstract: Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: August 12, 2008
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Matthias Liebergesell, Jinrui Shi, George W. Singletary
  • Patent number: 7317146
    Abstract: The invention alters the physical characteristics of starch granules in a plant. Methods are provided for reducing starch granule size by stably introducing into the genome of the plant or plant cell a DNA construct comprising a polynucleotide encoding a polypeptide operably linked to a promoter that drives expression in a plant and operably linked to a plastid transit peptide. Compositions of the invention include transgenic plants and seeds having a reduced starch granule size. Compositions also include starch isolated from these plants and seeds. The modified starch granules find use in a wide range of food, feed, and industrial applications.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: January 8, 2008
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: George W. Singletary, Lan Zhou
  • Publication number: 20070261136
    Abstract: The present invention is directed to compositions and methods for producing a dominant high-amylopectin starch trait in cereal grain and methods for screening grain for genetic variation in hydrolysis and fermentation time.
    Type: Application
    Filed: April 30, 2007
    Publication date: November 8, 2007
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: George W. Singletary, Lan Zhou, Kimberly F. Glassman, Douglas M. Haefele
  • Patent number: 7098381
    Abstract: Methods are provided that diminish UDPGdH expression in plant cells as compared to wild-type plant cells. These methods find use in increasing the nutritional value of animal feed and improving processes for extraction of starch from plant seeds. Also provided are expression vectors capable of diminishing UDPGdH expression in plant cells, and transgenic plants expressing diminished levels of UDPGdH.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: August 29, 2006
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: George W. Singletary, Scott E. Nichols, Kanwarpal S. Dhugga
  • Patent number: 6734341
    Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in starch biosynthesis. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering the amount and/or morphology of starch in plants.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: May 11, 2004
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: George W. Singletary, Lan Zhou
  • Publication number: 20040025203
    Abstract: Methods are provided that diminish UDPGdH expression in plant cells as compared to wild-type plant cells. These methods find use in increasing the nutritional value of animal feed and improving processes for extraction of starch from plant seeds. Also provided are expression vectors capable of diminishing UDPGdH expression in plant cells, and transgenic plants expressing diminished levels of UDPGdH.
    Type: Application
    Filed: March 13, 2002
    Publication date: February 5, 2004
    Inventors: George W. Singletary, Scott E. Nichols, Kanwarpal S. Dhugga
  • Patent number: 6639126
    Abstract: The invention alters the physical characteristics of storage polyglucans including starch. Methods are provided to modify the polyglucan biosynthesis pathway by simultaneously altering the activity of a pullulanase debranching enzyme and the activity of another polypeptide in the polyglucan biosynthesis pathway. Compositions of the invention include transgenic plants and seeds having a modified polyglucan structure and/or content and elevated phytoglycogen levels. Additional compositions include a grain with increased energy availability for improved feed quality and industrial uses. Further compositions include a polyglucan with improved functional properties useful in a wide range of food and industrial applications.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: October 28, 2003
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Vincent J. H. Sewalt, George W. Singletary
  • Publication number: 20030135883
    Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in starch biosynthesis. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering the amount and/or morphology of starch in plants.
    Type: Application
    Filed: January 11, 2002
    Publication date: July 17, 2003
    Inventors: George W. Singletary, Lan Zhou
  • Patent number: 6423886
    Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in starch biosynthesis. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering the amount and/or morphology of starch in plants.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: July 23, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: George W. Singletary, Lan Zhou
  • Patent number: 6399859
    Abstract: Isolated nucleic acid molecules are provided that encode maize UDPGdH variant UDPGdH, and mutant UDPGdH proteins. These nucleic acid molecules can be used to produce transgenic plants having altered quality or quantity of starch. Also provided are vectors capable of expressing such nucleic acid molecules, host cells containing, such vectors, and polypeptides encoded by such nucleic acids.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: June 4, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Scott E. Nichols, Kanwarpal S. Dhugga, George W. Singletary, Court A. Saunders, Derrick Witcher, Wesley B. Bruce, Lynne E. Sims, Guihua Lu, Gan-Yuan Zhong