Patents by Inventor George Yiannikouros

George Yiannikouros has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230357176
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 24, 2023
    Publication date: November 9, 2023
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Patent number: 11634401
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: April 25, 2023
    Assignee: Amazentis SA
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Publication number: 20210198225
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 5, 2021
    Publication date: July 1, 2021
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Patent number: 10906883
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: February 2, 2021
    Assignee: Amazentis SA
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Publication number: 20190263772
    Abstract: Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 27, 2019
    Publication date: August 29, 2019
    Inventors: Wolfgang Skranc, George Yiannikouros, Alexander Trofimov, Zhixing Shan, Christopher Goss
  • Publication number: 20190254312
    Abstract: An air-stable, high-melt 1a-hydroxy-vitamin D3 compound, methods for preparing an animal feed composition, methods of preparing 1a-hydroxy-vitamin D3, methods of enhancing phytate phosphorus and calcium utilization, and an animal feed regime are provided.
    Type: Application
    Filed: February 27, 2019
    Publication date: August 22, 2019
    Inventors: Hardy M. EDWARDS, III, George MAJETICH, Richard HILL, Dezhi SHA, George YIANNIKOUROS
  • Publication number: 20160345608
    Abstract: An air-stable, high-melt 1a-hydroxy-vitamin D3 compound, methods for preparing an animal feed composition, methods of preparing 1?-hydroxy-vitamin D3, methods of enhancing phytate phosphorus and calcium utilization, and an animal feed regime are provided.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 1, 2016
    Inventors: Hardy M. Edwards, III, George Majetich, Richard Hill, Dezhi Sha, George Yiannikouros
  • Publication number: 20120184514
    Abstract: An air-stable, high-melt 1a-hydroxy-vitamin D3 compound, methods for preparing an animal feed composition, methods of preparing 1?-hydroxy-vitamin D3, methods of enhancing phytate phosphorus and calcium utilization, and an animal feed regime are provided.
    Type: Application
    Filed: June 29, 2010
    Publication date: July 19, 2012
    Applicant: Vitamin Derivatives Inc.
    Inventors: Hardy M. Edwards, George Majetich, Richard Hill, Dezhi Sha, George Yiannikouros
  • Publication number: 20070208045
    Abstract: The present invention provides sulfonylurea compounds of formula (VIII) and pharmaceutically acceptable derivatives thereof and a process for making thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention also provides a method for inhibition platelet ADP receptor and preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (VIII) or a pharmaceutically acceptable salt or forms thereof.
    Type: Application
    Filed: November 3, 2006
    Publication date: September 6, 2007
    Applicant: Portola Pharmaceuticals, Inc.
    Inventors: Robert Scarborough, Carroll Scarborough, Anjali Pandey, Mukund Mehrotra, Michael Cruskie, David White, George Yiannikouros
  • Publication number: 20070155699
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Application
    Filed: August 16, 2006
    Publication date: July 5, 2007
    Applicant: Anacor Pharmaceuticals
    Inventors: Stephen Baker, Tsutomu Akama, Michael Alley, Steven Benkovic, Michael DiPierro, Vincent Hernandez, Karin Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk Maples, Jacob Plattner, Fernando Rock, Virginia Sanders, Aaron Stemphoski, George Yiannikouros, Siead Zegar, Yong-Kang Zhang, Huchen Zhou
  • Publication number: 20060074089
    Abstract: The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and methods of using the same.
    Type: Application
    Filed: September 16, 2005
    Publication date: April 6, 2006
    Inventors: Jeffrey Whitten, Fabrice Pierre, Collin Regan, Michael Schwaebe, George Yiannikouros, Michael Jung
  • Publication number: 20060063761
    Abstract: The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a Lewis acid having formula MLn, wherein L is a halogen atom or an organic radical, n is 3-5, and M is a group III elemental atom, a group IV elemental atom, As, Sb, V or Fe, wherein A, B, V, X, Z, W, R1, R2, R5, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8 are substituents. Z4, Z5, Z6, Z7, and Z8 are substituents.
    Type: Application
    Filed: June 9, 2005
    Publication date: March 23, 2006
    Inventors: Jeffrey Whitten, Fabrice Pierre, Collin Regan, Michael Schwaebe, George Yiannikouros, Michael Jung
  • Patent number: 7009049
    Abstract: The present invention is directed to methods for the preparation of enantiomerically pure quinazolinones, intermediates in such methods, and compositions comprising such quinazolinones.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: March 7, 2006
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Gustave Bergnes, Edward Ha, George Yiannikouros, Panos Kalaritis, Brandon E. Yonce, Kurt Alan Welday, Jr.
  • Publication number: 20060025470
    Abstract: The present invention provides intermediates, synthetic methods and novel urea compositions of matter.
    Type: Application
    Filed: January 11, 2005
    Publication date: February 2, 2006
    Inventors: Bradley Morgan, George Yiannikouros, Michael Cruskie, Christopher Goss
  • Publication number: 20050004377
    Abstract: Disclosed are process steps and processes for producing chromane compounds, preferably 2-(6-amino-chroman-2yl) acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
    Type: Application
    Filed: May 16, 2001
    Publication date: January 6, 2005
    Inventors: Robert Scarborough, Panos Kalaritis, George Yiannikouros, Michel Cruskie, Dezhi Sha
  • Publication number: 20040067969
    Abstract: The present invention provides intermediates, synthetic methods and novel quinazolinone compositions of matter.
    Type: Application
    Filed: February 14, 2003
    Publication date: April 8, 2004
    Inventors: Gustave Bergnes, Edward Ha, George Yiannikouros, Panos Kalaritis, Brandon E. Yonce, Kurt Alan Welday