Patents by Inventor Georgianna S. Harris

Georgianna S. Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of improving in-vitro fertilization
    Patent number: 6352997
    Abstract: The present invention provides for a method of treating polycystic ovary syndrome in a subject in need of such treatment comprising the administration of a therapeutically effective amount of a compound of structural formula I: to the subject. The present invention further provides for a method for improving fertility and the response to in vitro fertilization (I.V.F.), comprising administration of therapeutically effective amount of compound of structural formula I to the subject. Further, the present invention provides for compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for treating polycystic ovary syndrome or for improving fertility or the response to in vitro fertilization (I.V.F.).
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: March 5, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Joanne Waldstreicher, Georgianna S. Harris
  • Irreversible inhibition of human 5.alpha.-reductase
    Patent number: 5962442
    Abstract: The invention concerns the treatment of hyderandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. Until the present invention, it was not know or predicted that 3-oxo-4-azasteroids having 1,2-double bond would form a complex with NADPH by the mechanism of 5.alpha.-reductase in vivo. The invention further relates to the novel inhibitor-cofactor complex and pharmaceutical compositions containing the complex.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: October 5, 1999
    Assignee: Merck & Co., INc.
    Inventors: Herb G. Bull, Georgianna S. Harris
  • Methods for treating polycystic ovary syndrome
    Patent number: 5935968
    Abstract: The present invention provides for a method of treating polycystic ovary syndrome in a subject in need of such treatment comprising the administration of a therapeutically effective amount of a compound of structural formula I: ##STR1## to the subject. The present invention further provides for a method for improving fertility and the response to in vitro fertilization (I.V.F.), comprising administration of therapeutically effective amount of compound of structural formula I to the subject. Further, the present invention provides for compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for treating polycystic ovary syndrome or for improving fertility or the response to in vitro fertilization (I.V.F.).
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: August 10, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Joanne Waldstreicher, Georgianna S. Harris
  • 7.beta.-substituted-4-aza-5.alpha.-androstan-3-ones as 5.alpha.-reductase inhibitors
    Patent number: 5710275
    Abstract: Described are new 7.beta.-substituted 4-aza-5.alpha.-androstan-3-ones and related compounds as 5.alpha.-reductase inhibitors.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: January 20, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Raman K. Bakshi, Gary H. Rasmusson, Richard L. Tolman, Gool F. Patel, Georgianna S. Harris, Donald W. Graham, Bruce E. Witzel
  • Treatment of hyperandrogenic conditions
    Patent number: 5656613
    Abstract: The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. Until the present invention, it was not known or predicted that 3-oxo-4-azasteroids having a 1,2-double bond would form a complex with NADPH by the mechanism of 5.alpha.-reductase in vivo. The invention further relates to the novel inhibitor-cofactor complex and pharmaceutical compositions containing the complex.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: August 12, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Herb G. Bull, Georgianna S. Harris