Patents by Inventor Georgina Hotter Corripio

Georgina Hotter Corripio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell therapy with polarized macrophages for tissue regeneration
    Patent number: 10724004
    Abstract: The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype. The method comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, thus they are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the method, as well as a device for inducing hypoxia and re-oxygenation conditions on isolated macrophages according to the method.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: July 28, 2020
    Assignee: XCELL MEDICAL SOLUTIONS, S.L.
    Inventors: María Georgina Hotter Corripio, Ana Maria Sola Martínez, Jorge Vicente Martín Cordero, Pablo García De La Riva Mestre, Rubén Domínguez Sánchez, Jaime Sánchez Moreno, Xavier Ginesta Buch, Anna Rodríguez García, Adrián Castillo García
  • CELL THERAPY WITH POLARIZED MACROPHAGES FOR TISSUE REGENERATION
    Publication number: 20180087031
    Abstract: The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype useful for tissue repair. The method described in the present invention comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, such as NGAL and anti-inflammatory cytokines (IL-10). Thus, M2 macrophages obtained by this method are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the described method. The invention further refers to a device for inducing hypoxia and re-oxygenation conditions on isolated macrophages according to the described method.
    Type: Application
    Filed: September 25, 2017
    Publication date: March 29, 2018
    Inventors: María Georgina HOTTER CORRIPIO, Ana Maria SOLA MARTÍNEZ, Jorge Vicente MARTÍN CORDERO, Pablo GARCÍA DE LA RIVA MESTRE, Rubén DOMÍNGUEZ SÁNCHEZ, Jaime SÁNCHEZ MORENO, Xavier GINESTA BUCH, Anna RODRÌGUEZ GARCIA, Adrián CASTILLO GARCÍA
  • URINARY NEUROPILIN-1 (NRP-1) AS A PROGNOSTIC MARKER FOR NEPHRITIS AND LUPUS NEPHRITIS
    Publication number: 20160244835
    Abstract: This invention refers to the methods for predicting the progress of nephritis and lupus nephritis in an individual. This invention also refers to the methods for evaluating the development of nephritis, particularly lupus nephritis, in an individual, and his/her response to a treatment.
    Type: Application
    Filed: July 9, 2014
    Publication date: August 25, 2016
    Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
    Inventors: Georgina HOTTER CORRIPIO, Ana Maria SOLA MARTINEZ, Jose Luis VINAS MUNOZ, Josep ORDIROS, Maria Teresa TORRES SALIDO, Josefina CORTES HERNANDEZ
  • USE OF CARBONIC ANHYDRASE II FOR PRODUCING A DRUG
    Publication number: 20130101565
    Abstract: The present invention falls within the field of biomedicine. Specifically, the present invention relates to the use of carbonic anhydrase II for the manufacture of a medicament for the prevention and/or treatment of the damage caused by ischemia, ischemia followed by reperfusion or toxins, acute failure or rejection of a transplanted organ, preferably the kidney. In a preferred embodiment, the toxin is cisplatin.
    Type: Application
    Filed: July 12, 2010
    Publication date: April 25, 2013
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
    Inventors: Georgina Hotter Corripio, José Luis Viñas, Anna Sola Martínez