Patents by Inventor Georgios Sarakinos
Georgios Sarakinos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8420683Abstract: The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched ?-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.Type: GrantFiled: June 3, 2008Date of Patent: April 16, 2013Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.Inventors: Georgios Sarakinos, Wilhelmus Hubertus Joseph Boesten, Dennis Heemskerk, Ben De Lange
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Patent number: 8110213Abstract: Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases.Type: GrantFiled: July 15, 2008Date of Patent: February 7, 2012Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Antonios G. Mikos, Robert S. Langer, Joseph P. Vacanti, Linda G. Griffith, Georgios Sarakinos
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Patent number: 8105807Abstract: The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched ?-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives.Type: GrantFiled: October 2, 2008Date of Patent: January 31, 2012Assignee: DSM IP Assets B.V.Inventors: Georgios Sarakinos, Ben De Lange
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Publication number: 20100221796Abstract: The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched ?-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives.Type: ApplicationFiled: October 2, 2008Publication date: September 2, 2010Applicant: DSM IP Assets B.V.Inventors: Georgios Sarakinos, Ben De Lange
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Publication number: 20100174092Abstract: The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched ?-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.Type: ApplicationFiled: June 3, 2008Publication date: July 8, 2010Inventors: Georgios Sarakinos, Wilhelmus Hubertus Joseph Boesten, Dennis Heemskerk, Ben De Lange
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Publication number: 20100143981Abstract: The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched ?-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-?-amino acid from a corresponding hydantoin.Type: ApplicationFiled: December 4, 2007Publication date: June 10, 2010Inventors: Monika Rusnak-Müller, Oliver May, Petrus Johannes Hermsen, Henricus Martinus Maria Gerardus Straatman, Wolfgang Skranc, Wilhelmus Hubertus Joseph Boesten, Dannis Heemskerk, Ben De Lange, Georgios Sarakinos
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Publication number: 20090060969Abstract: Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases.Type: ApplicationFiled: July 15, 2008Publication date: March 5, 2009Applicant: Massachusetts Institute of TechnologyInventors: Antonios G. Mikos, Robert S. Langer, Joseph P. Vacanti, Linda G. Griffith, Georgios Sarakinos
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Patent number: 7462471Abstract: Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases.Type: GrantFiled: February 10, 2004Date of Patent: December 9, 2008Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Antonios G. Mikos, Joseph P. Vacanti, Robert S. Langer, Linda G. Griffith, Georgios Sarakinos
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Publication number: 20070142657Abstract: The invention relates to protected unsaturated alcohol with formula (R1—O)mPG, wherein R1 represents a linear, straight-chain aliphatic hydrocarbon group containing one or more double bonds and having 26-30 C-atoms, m is 1 or 2 and PG, forming an ether group in combination with the —O— of the former primary alcohol, represents a protecting group chosen from the group of substituted methyl ethers, substituted ethyl ethers, (substituted) benzyl ethers and (substituted) silyl ethers with at least one substituent on the Si-atom being not a methyl group, in case m=1; and a diol protecting group in case m=2; A protected saturated alcohol with formula (R2—O—)mPG, herein R2 represents a linear straight-chain alkyl group with 26-30 C-atoms and PG and m are as defined above; unsaturated alcohols with formula R1OH wherein R1 represents a linear, straight-chain aliphatic hydrocarbon group containing one, two or three double bonds and having 27 C-atoms, a linear, straight-chain aliphatic hydrocarbon group containing one oType: ApplicationFiled: November 17, 2004Publication date: June 21, 2007Inventors: Georgios Sarakinos, Quirinus Broxterman
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Publication number: 20070083058Abstract: The invention relates to protected alcohol with formula (R1—O—)mPG, wherein R1 represents a linear, straight-chain alkyl group having 26-30 C-atoms, m is 1 or 2, and PG, forming an ether group in combination with the —O— of the former primary alcohol, represents a protecting group chosen from the group of substituted methyl, substituted ethyl, substituted benzyl and (substituted) silyl groups with at least one substituent on the Si-atom being not a methyl group, in case m=1; and a diol protecting group in case m=2, with the proviso that PG is no saccharide. The invention further relates to process for the preparation of such protected alcohols via an organometallic cross coupling reaction.Type: ApplicationFiled: November 17, 2004Publication date: April 12, 2007Inventors: Georgios Sarakinos, Quirinus Broxterman
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Patent number: 6689608Abstract: Polymeric materials are used,to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases.Type: GrantFiled: September 26, 2000Date of Patent: February 10, 2004Assignee: Massachusetts Institute of TechnologyInventors: Antonios G. Mikos, Robert S. Langer, Joseph P. Vacanti, Linda G. Griffith, Georgios Sarakinos
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Patent number: 5514378Abstract: Biocompatible porous polymer membranes are prepared by dispersing salt particles in a biocompatible polymer solution. The solvent in which the polymer is dissolved is evaporated to produce a polymer/salt composite membrane. The polymer can then be heated and cooled at a predetermined constant rate to provide the desired amount of crystallinity. Salt particles are leached out of the membrane by immersing the membrane in water or another solvent for the salt but not the polymer. The membrane is dried, resulting in a porous, biocompatible membrane to which dissociated cells can attach and proliferate. A three-dimensional structure can be manufactured using the polymer membranes by preparing a contour drawing of the shape of the structure, determining the dimensions of thin cross-sectional layers of the shape, forming porous polymer membranes corresponding to the dimensions of the layers, and laminating the membranes together to form a three-dimensional matrix having the desired shape.Type: GrantFiled: February 1, 1993Date of Patent: May 7, 1996Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Antonios G. Mikos, Georgios Sarakinos, Joseph P. Vacanti, Robert S. Langer, Linda G. Cima